Source https://www.fightaging.org/archives/2021/02/towards-therapies-targeting-the-mechanisms-of-transthyretin-amyloidosis/
There are twenty or so different proteins in the human body that can form amyloids, a misfolding of the protein that can encourage other molecules of the same protein to misfold in the same way. These misfolded proteins join together to form solid deposits – amyloids – that are associated with a complex, problematic biochemistry that disrupts cell and tissue function. Once underway in earnest, this formation of amyloids and the resulting pathology is known as amyloidosis.
Transthyretin is one of the proteins capable of forming amyloid, and transthyretin amyloidosis is found to some degree in every older individual. Most past research has focused on genetic mutations that c…
Source https://www.fightaging.org/archives/2021/02/towards-therapies-targeting-the-mechanisms-of-transthyretin-amyloidosis/
There are twenty or so different proteins in the human body that can form amyloids, a misfolding of the protein that can encourage other molecules of the same protein to misfold in the same way. These misfolded proteins join together to form solid deposits – amyloids – that are associated with a complex, problematic biochemistry that disrupts cell and tissue function. Once underway in earnest, this formation of amyloids and the resulting pathology is known as amyloidosis.
Transthyretin is one of the proteins capable of forming amyloid, and transthyretin amyloidosis is found to some degree in every older individual. Most past research has focused on genetic mutations that c…
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