Clearance of metabolic waste from the brain falters with age, leading to an increased presence of toxic protein aggregates, such as the amyloid-β associated with Alzheimer’s disease, but also others. Evidence has emerged for mechanical issues in the flow of cerebrospinal fluid out of the brain to be important in this contributing cause of neurodegenerative disease. If the cerebrospinal fluid isn’t carrying away enough of the metabolic waste, then a <a href="https://www.fightaging.org/archives/2013/07/a-perspective-on-the-garbage-catastrophe-of-aging/"…
Perivascular Macrophages Appear Important in Clearance of Molecular Waste from the Brain
Clearance of metabolic waste from the brain falters with age, leading to an increased presence of toxic protein aggregates, such as the amyloid-β associated with Alzheimer’s disease, but also others. Evidence has emerged for mechanical issues in the flow of cerebrospinal fluid out of the brain to be important in this contributing cause of neurodegenerative disease. If the cerebrospinal fluid isn’t carrying away enough of the metabolic waste, then a <a href="https://www.fightaging.org/archives/2013/07/a-perspective-on-the-garbage-catastrophe-of-aging/"…