Investigating PGE2, Cellular Senescence, and Macrophage Function in the Aging Lungs

Source https://www.fightaging.org/archives/2022/11/investigating-pge2-cellular-senescence-and-macrophage-function-in-the-aging-lungs/

Researchers here show that blocking increased PGE2 signaling in the aging lung helps to restore resistance to influenza infection. There is an interaction between PGE2, cellular senescence in cells of the alveoli in the lung, and the behavior of local macrophages of the innate immune system. It remains to be seen whether PGE2 signaling is regulating much the same issues connected to cellular senescence elsewhere in the body.

Previous research by another group showed that when macrophages from an old mouse were put into a young mouse, and cells looked young again. Signs pointed to a lipid immune modu…

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