Glutaminase inhibitors can potentially eliminate senescent cells from aged tissues, another in the growing list of categories of senolytic compound. Researchers here test the proposition in various skin models, some involving immunodeficient mice hosting human skin grafts. At this point there are so many different senolytics that studies should start to focus on comparing efficacy. Where there is data to compare directly, development efforts conducted over the last decade have so far failed to greatly improve on the dasatinib and quercetin approach, the first senolytic treatment tested i…
Testing a Glutaminase Inhibitor to Clear Senescent Cells in Skin Models
Glutaminase inhibitors can potentially eliminate senescent cells from aged tissues, another in the growing list of categories of senolytic compound. Researchers here test the proposition in various skin models, some involving immunodeficient mice hosting human skin grafts. At this point there are so many different senolytics that studies should start to focus on comparing efficacy. Where there is data to compare directly, development efforts conducted over the last decade have so far failed to greatly improve on the dasatinib and quercetin approach, the first senolytic treatment tested i…