Source https://www.fightaging.org/archives/2022/12/reviewing-the-role-of-sirt6-in-aging/
While much the history of work on sirtuins is one of disappointing results, the majority of that work involved SIRT1. Both SIRT3 and SIRT6 may be more interesting, based on animal studies conducted since the SIRT1 era. SIRT3 localizes to the mitochondria, and mitochondrial function is important in the context of aging. Researchers have shown that SIRT3 upregulation in mice improves hematopoietic stem cell function. SIRT6 upregulation, however, has been shown to <a href="https://www.fightaging.org/archives/2021/06/sirt6-over…
Source https://www.fightaging.org/archives/2022/12/reviewing-the-role-of-sirt6-in-aging/
While much the history of work on sirtuins is one of disappointing results, the majority of that work involved SIRT1. Both SIRT3 and SIRT6 may be more interesting, based on animal studies conducted since the SIRT1 era. SIRT3 localizes to the mitochondria, and mitochondrial function is important in the context of aging. Researchers have shown that SIRT3 upregulation in mice improves hematopoietic stem cell function. SIRT6 upregulation, however, has been shown to <a href="https://www.fightaging.org/archives/2021/06/sirt6-over…
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