The first senolytic therapy to be tested in mice and humans was the combination of dasatinib and quercetin. This continues to be tested in human trials by the Mayo Clinic, and has been shown to reduce the burden of senescent cells in humans to much the same degree as it does in mice. It remains to be seen as to whether any of the many forms of senolytic treatment under development are very much better at clearing senescent cells from aged tissues than dasatinib and quercetin. Either way, it is likely that the use of multiple different senolytics will be better than one alone, due to tissue by tissue differences in biodistribut…
An Example of Senolytics Impoving Metabolic Function in Old Mice
The first senolytic therapy to be tested in mice and humans was the combination of dasatinib and quercetin. This continues to be tested in human trials by the Mayo Clinic, and has been shown to reduce the burden of senescent cells in humans to much the same degree as it does in mice. It remains to be seen as to whether any of the many forms of senolytic treatment under development are very much better at clearing senescent cells from aged tissues than dasatinib and quercetin. Either way, it is likely that the use of multiple different senolytics will be better than one alone, due to tissue by tissue differences in biodistribut…