Source https://www.fightaging.org/archives/2023/01/towards-microneedle-delivery-of-lnp-mrna-gene-therapies-for-skin-aging/
The skin is arguably one of the easiest of the large organs in the body to target for delivery of gene therapies, via established microneedle approaches. Nonetheless, much of the initial thrust of gene therapy clinical development focused instead on the liver, one of the other more tractable targets. Most material injected into the bloodstream ends up in the liver, and a single injection is logistically easier than coverage of large amounts of skin via microneedle patches, among other reasons.
Given the advent of messenger RNA (mRNA) encapsulated in lipid nanoparticles (either artificial or repurposed <a href="https://en.wikipedia.org/wiki/Vesicle_(biology_and_c…
Source https://www.fightaging.org/archives/2023/01/towards-microneedle-delivery-of-lnp-mrna-gene-therapies-for-skin-aging/
The skin is arguably one of the easiest of the large organs in the body to target for delivery of gene therapies, via established microneedle approaches. Nonetheless, much of the initial thrust of gene therapy clinical development focused instead on the liver, one of the other more tractable targets. Most material injected into the bloodstream ends up in the liver, and a single injection is logistically easier than coverage of large amounts of skin via microneedle patches, among other reasons.
Given the advent of messenger RNA (mRNA) encapsulated in lipid nanoparticles (either artificial or repurposed <a href="https://en.wikipedia.org/wiki/Vesicle_(biology_and_c…
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