Source https://www.fightaging.org/archives/2023/04/unity-biotechnology-demonstrates-again-that-localized-use-of-senolytics-is-not-so-great/
Most of the research relevant to the question of whether localized clearance of senescent cells can effectively treat age-related conditions has taken place in the context of osteoarthritis. While adding senescent cells to a joint is sufficient to provoke the onset of osteoarthritis, clearing senescent cells from only the joint region is not sufficient to produce significant patient benefits. The present consensus is that the senescent cells present in the rest of the body are producing a significant contribution by their signaling: those cells may be more distant, and their contributions thus more dilute, but there are a lot more of them.
<a href="https://www.fightaging.org/archives/201…
Source https://www.fightaging.org/archives/2023/04/unity-biotechnology-demonstrates-again-that-localized-use-of-senolytics-is-not-so-great/
Most of the research relevant to the question of whether localized clearance of senescent cells can effectively treat age-related conditions has taken place in the context of osteoarthritis. While adding senescent cells to a joint is sufficient to provoke the onset of osteoarthritis, clearing senescent cells from only the joint region is not sufficient to produce significant patient benefits. The present consensus is that the senescent cells present in the rest of the body are producing a significant contribution by their signaling: those cells may be more distant, and their contributions thus more dilute, but there are a lot more of them.
<a href="https://www.fightaging.org/archives/201…
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