KDM5C Inhibition Reduces Osteoclast Activity, Increasing Bone Density

Source https://www.fightaging.org/archives/2023/04/kdm5c-inhibition-reduces-osteoclast-activity-increasing-bone-density/

Bone tissue is constantly remodeled through the activity of osteoblast cells, depositing extracellular matrix, and osteoclast cells, breaking down extracellular matrix. With age, the balance between these two populations shifts to favor osteoclasts, and the result is loss of bone density leading to osteoporosis. The research community is actively engaged in finding better ways to shift this balance back towards osteoblast activity. Here, researchers describe an approach that inhibits the generation of osteoclast cells.

It is well-established that women experience disproportionately lower bone mass than men throughout their lives. Loss of bone mass accelerates with menopause…