A number of lines of evidence implicate senescent microglia in the development of neurodegenerative conditions. Microglia are innate immune cells of the central nervous system, analogous to macrophages elsewhere in the body. Microglia appear to become more inflammatory with age, but this isn’t just an amplification of inflammatory signaling that arises due to age-related dysfunctions such as mislocalization of mitocho…
Evidence For Autophagy to be Important to Microglial Dysfunction in the Aged Brain
A number of lines of evidence implicate senescent microglia in the development of neurodegenerative conditions. Microglia are innate immune cells of the central nervous system, analogous to macrophages elsewhere in the body. Microglia appear to become more inflammatory with age, but this isn’t just an amplification of inflammatory signaling that arises due to age-related dysfunctions such as mislocalization of mitocho…