Investigating the Gut Microbiome of Centenarians

Source https://www.fightaging.org/archives/2023/06/investigating-the-gut-microbiome-of-centenarians/

The extensive, well-funded search for genetic differences in long-lived individuals has found little: small effect sizes, and only a few genetic variants that replicate in multiple studies. Will the search for gut microbiome differences characteristic of long-lived individuals do any better? This remains to be seen, as the research community is only a few studies into this exercise, and it takes more than a few studies to build a consensus. The evidence to date suggests cautiously optimism, as researchers do see differences in microbial species abundance in exceptionally old individuals versus merely old individuals. As noted here, viral diversity may also be important.

Studying 176 healthy Japanese <a href="https://en.wikipedia.org/w…

Source https://www.fightaging.org/archives/2023/06/investigating-the-gut-microbiome-of-centenarians/

The extensive, well-funded search for genetic differences in long-lived individuals has found little: small effect sizes, and only a few genetic variants that replicate in multiple studies. Will the search for gut microbiome differences characteristic of long-lived individuals do any better? This remains to be seen, as the research community is only a few studies into this exercise, and it takes more than a few studies to build a consensus. The evidence to date suggests cautiously optimism, as researchers do see differences in microbial species abundance in exceptionally old individuals versus merely old individuals. As noted here, viral diversity may also be important.

Studying 176 healthy Japanese <a href="https://en.wikipedia.org/w…

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