Source https://www.fightaging.org/archives/2023/09/is-transfusion-of-young-blood-essentially-a-form-of-extracellular-vesicle-therapy/
Are beneficial effects of transfusion of blood fractions from young individuals to old individuals observed in animal studies the result of transferring the contents of extracellular vesicles rather than any signal molecules not packaged into a vesicle? While considering this question, it is worth noting that transfusion of plasma has quite mixed outcomes in both mice and humans. It doesn’t appear to be a good approach to therapy, based on the results to date.
This is unlike the robust benefits produced in old animals by heterochronic parabiosis, linking the circulatory system of an old and a young mouse. In a parabiosis study, the old mouse is getting a great deal more of everything that might be found in young b…
Source https://www.fightaging.org/archives/2023/09/is-transfusion-of-young-blood-essentially-a-form-of-extracellular-vesicle-therapy/
Are beneficial effects of transfusion of blood fractions from young individuals to old individuals observed in animal studies the result of transferring the contents of extracellular vesicles rather than any signal molecules not packaged into a vesicle? While considering this question, it is worth noting that transfusion of plasma has quite mixed outcomes in both mice and humans. It doesn’t appear to be a good approach to therapy, based on the results to date.
This is unlike the robust benefits produced in old animals by heterochronic parabiosis, linking the circulatory system of an old and a young mouse. In a parabiosis study, the old mouse is getting a great deal more of everything that might be found in young b…
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