Senolytic drugs selectively destroy senescent cells. First generation senolytic drugs generally target apoptosis-resistance mechanisms and have off-target effects, though these appear quite acceptable in the case of dasatinib and quercetin, given the potential benefits. Nonetheless, researchers are expending a great deal of effort to search for ways to produce far more selective targeting of senescent cells. One example is the category of prodrugs that are only transformed into their cytotoxic form <a href="https://www.fightaging.org/archives/2020/05…
A Novel Approach to Exploiting the Peculiar Biochemistry of Senescent Cells to Produce a Highly Targeted Senolytic
Senolytic drugs selectively destroy senescent cells. First generation senolytic drugs generally target apoptosis-resistance mechanisms and have off-target effects, though these appear quite acceptable in the case of dasatinib and quercetin, given the potential benefits. Nonetheless, researchers are expending a great deal of effort to search for ways to produce far more selective targeting of senescent cells. One example is the category of prodrugs that are only transformed into their cytotoxic form <a href="https://www.fightaging.org/archives/2020/05…