In Search of Mammalian Gene Duplications Correlated with Species Longevity

Source https://www.fightaging.org/archives/2023/10/in-search-of-mammalian-gene-duplications-correlated-with-species-longevity/

Duplication of a genetic sequence is a common occurrence over evolutionary time, one of the mechanisms by which species evolve. Noteworthy duplications include the many versions of cancer suppressor gene TP53 that are observed in the elephant genome. Large animals have many more cells than small animals, and so the evolution of greater size must be accompanied by the evolution of ways to greatly reduce cancer risk per cell.

Researchers here report on the results of searching for specific gene duplications in mammalian species that correlate with species longevity. This provides starting points for further study of the mechanisms that determine sizable differences in mammalian life spans, at present a poorly understo…

Source https://www.fightaging.org/archives/2023/10/in-search-of-mammalian-gene-duplications-correlated-with-species-longevity/

Duplication of a genetic sequence is a common occurrence over evolutionary time, one of the mechanisms by which species evolve. Noteworthy duplications include the many versions of cancer suppressor gene TP53 that are observed in the elephant genome. Large animals have many more cells than small animals, and so the evolution of greater size must be accompanied by the evolution of ways to greatly reduce cancer risk per cell.

Researchers here report on the results of searching for specific gene duplications in mammalian species that correlate with species longevity. This provides starting points for further study of the mechanisms that determine sizable differences in mammalian life spans, at present a poorly understo…

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