Examining Human Brain Cell Changes in the Early Stages of Alzheimer's Disease

Source https://www.fightaging.org/archives/2023/10/examining-human-brain-cell-changes-in-the-early-stages-of-alzheimers-disease/

Prevention is both better than a cure and easier to achieve than a cure. Intervening early, prior to evident clinical symptoms of disease, is always desirable. This is challenging in the case of Alzheimer’s disease because (a) there is little access to human brain tissue from people in the early stages of the condition, for ethical and regulatory reasons, and (b) Alzheimer’s doesn’t naturally occur in mice and other readily available mammalian species, so animal models of Alzheimer’s are highly artificial, embodying assumptions about which disease processes are important. In this context, one can only learn from human brains. Here, researchers report on the results of a rare opportunity to study brain tissue samples from patients with early stage Alzheimer’s disease.

Most Alzheimer’s disease research on human brain tissue has stu…

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