A Gene Therapy to Promote Cardiomyocyte Proliferation Improves Late Stage Heart Failure in Rats

Source https://www.fightaging.org/archives/2024/02/a-gene-therapy-to-promote-cardiomyocyte-proliferation-improves-late-stage-heart-failure-in-rats/

Researchers have developed a gene therapy that upregulates of Cdk1 and Cdk4 in heart muscle. These genes provoke cardiomyocytes into replication, and this has been shown to improve function in the context of heart failure. Here, researchers show that this can help to improve heart function even comparatively late into the development of progressive heart failure, broadening the number of patients who can potentially benefit once this reaches the clinic.

Heart failure remains the leading cause of mortality in the U.S. During a heart attack blood stops flowing into the heart. Without oxyg…

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