Aged Pancreatic Fibroblasts Secrete GDF-15, Encouraging Tumor Growth

Source https://www.fightaging.org/archives/2024/02/aged-pancreatic-fibroblasts-secrete-gdf-15-encouraging-tumor-growth/

Researchers here note one of a broad range of examples in which age-related changes in the state and behavior of non-cancerous cells results in a more hospitable environment for the growth of neighboring cancerous tissue. Cancer is an age-related condition not just because of increased damage to cells in older tissues, nor just because the immune system falters in its surveillance of potentially cancerous cells, but also due to other maladaptive changes that favor the metabolism and growth of some forms of cancerous cells.

A new study provides clues as to why pancreatic cancer is more common and aggressive in older people. It may also help scientists develop new therapeutic approaches for this difficult-to-treat canc…

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