Catalase to Reduce Mitochondrial Oxidative Stress Does Not Reduce Cellular Senescence

Source https://www.fightaging.org/archives/2024/03/catalase-to-reduce-mitochondrial-oxidative-stress-does-not-reduce-cellular-senescence/

Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now integrated into the cell. Mitochondria generate oxidative molecules as a consequence of the processes that generate the chemical energy store molecule adenosine triphosphate (ATP), used to power the cell. Those oxidative molecules cause damage, near all rapidly repaired. They also serve as signals, such as in the beneficial response to exercise. With aging, however, mitochondrial function becomes impaired and the degree of oxidative stress generated by the operation of mitochondria becomes harmful.

Researchers have in the past produced modestly extended life in short-lived model organisms by overexpression of natural mitochondrial a…

Source https://www.fightaging.org/archives/2024/03/catalase-to-reduce-mitochondrial-oxidative-stress-does-not-reduce-cellular-senescence/

Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now integrated into the cell. Mitochondria generate oxidative molecules as a consequence of the processes that generate the chemical energy store molecule adenosine triphosphate (ATP), used to power the cell. Those oxidative molecules cause damage, near all rapidly repaired. They also serve as signals, such as in the beneficial response to exercise. With aging, however, mitochondrial function becomes impaired and the degree of oxidative stress generated by the operation of mitochondria becomes harmful.

Researchers have in the past produced modestly extended life in short-lived model organisms by overexpression of natural mitochondrial a…

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