Hypothesizing that Non-Coding RNAs are a Major Determinant of Species Life Span

Source https://www.fightaging.org/archives/2025/03/hypothesizing-that-non-coding-rnas-are-a-major-determinant-of-species-life-span/

Non-coding RNA sequences in the genome undergo transcription to produce an RNA molecule, but that RNA is not translated into a protein. Nonetheless, non-coding RNAs collectively form just as complex an interacting environment as proteins, important to the function of the cell. Non-coding RNAs remain poorly explored, as much of the work on cell biology to date has focused on proteins. It is unclear if the present catalog of non-coding RNAs is complete, and many of the known entries have unknown functions. Here, the argument is made for non-coding RNAs to collectively be an important determinant of species life span, based on the differences observed between short-lived and long-lived species.

Lifespan is a compl…

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