ADAM19 Knockdown Reduces Harmful Senescent Cell Signaling in Flies

Source https://www.fightaging.org/archives/2025/04/adam19-knockdown-reduces-harmful-senescent-cell-signaling-in-flies/

While much of the focus on cellular senescence in aging remains to find ways to selectively destroy these problem cells, there are also efforts to instead change their behavior. The reason why a growing burden of senescent cells in aged tissues is harmful, even when these cells make up only a tiny fraction of the overall cell population, is that they energetically secrete pro-inflammatory factors. This activity is disruptive to tissue structure and function when sustained over time. If senescent cells could be blocked from producing inflammatory secretions, their harms would be much reduced.

Accumulation of DNA damage can accelerate aging through cellular senescence. Previously, we established a <a href="https://en.wikipedia.org/wiki/Drosophila_mela…

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