Structural Features of DNA Differ Between Short-Lived Rats and Long-Lived Blind Mole Rats

Source https://www.fightaging.org/archives/2025/04/structural-features-of-dna-differ-between-short-lived-rats-and-long-lived-blind-mole-rats/

Which gene sequences are actively read by transcription machinery in the cell nucleus to produce RNA (some of which is then translated into proteins) is determined by the structure of nuclear DNA. The various assemblies of proteins making up that transcription machinery will read whatever sequence they can attach to. Regions of nuclear DNA can be packaged away and tightly furled, made inaccessible, or otherwise become accessible for a time through alterations to histone proteins, methylation of specific sites on the <a href="…

Source https://www.fightaging.org/archives/2025/04/structural-features-of-dna-differ-between-short-lived-rats-and-long-lived-blind-mole-rats/

Which gene sequences are actively read by transcription machinery in the cell nucleus to produce RNA (some of which is then translated into proteins) is determined by the structure of nuclear DNA. The various assemblies of proteins making up that transcription machinery will read whatever sequence they can attach to. Regions of nuclear DNA can be packaged away and tightly furled, made inaccessible, or otherwise become accessible for a time through alterations to histone proteins, methylation of specific sites on the <a href="…

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