PDGF-BB Protein Therapy Targets Pericytes to Encourage Nerve Regrowth

Source https://www.fightaging.org/archives/2025/04/pdgf-bb-protein-therapy-targets-pericytes-to-encourage-nerve-regrowth/

Researchers here report on a novel approach to encourage nerve regeneration, and demonstrate positive results in mice with spinal cord injury. Delivering platelet-derived growth factor BB (PDGF-BB) as a protein therapy to the injured nerve tissue changes the behavior of pericyte cells that normally interfere in any possible regrowth of the axons making up the nerve. In the presence of PDFG-BB, pericytes act to indirectly encourage axon regrowth. As the researchers note, this discovery likely has other applications beyond treating spinal cord injuries.

Spinal cord injuries are severe not only because they prevent transmission of information across the site of the injury, but because all of the <a href="https://en.wikipedia.org/wiki/Cardiova…

What Do You Think?

comments