One of the potential complications following surgery or injury (or indeed many other forms of acute stress) in older individuals is inflammation in the brain, triggered by inflammation in the body. This can lead to issues such as postoperative delerium, or more lasting cognitive decline. Researchers here provide evidence to suggest that the inflammatory signaling produced by senescent cells is an important mediator of this unwanted side-effect. This signaling can trigger senescence in bystander cells, and given sufficient levels of inflammation, this can occur throughout the body. Timely administration of <a href="https://www.fightaging.org/archives/2017/09/senolytic-therapies-to-clear-senescent-cells-will-transform-the-field-of-medic…
Clearance of Senescent Cells Reduces Neuroinflammation Following Surgery in Aged Mice
One of the potential complications following surgery or injury (or indeed many other forms of acute stress) in older individuals is inflammation in the brain, triggered by inflammation in the body. This can lead to issues such as postoperative delerium, or more lasting cognitive decline. Researchers here provide evidence to suggest that the inflammatory signaling produced by senescent cells is an important mediator of this unwanted side-effect. This signaling can trigger senescence in bystander cells, and given sufficient levels of inflammation, this can occur throughout the body. Timely administration of <a href="https://www.fightaging.org/archives/2017/09/senolytic-therapies-to-clear-senescent-cells-will-transform-the-field-of-medic…