The blood-brain barrier consists of specialized cells that line blood vessels passing through the central nervous system, only selectively allowing passage of molecules and cells between the circulation and the brain. Dysfunction of the blood-brain barrier allows unwanted molecules and cells into the brain, where they cause chronic inflammation and become an important contribution to the onset and progression of neurodegenerative conditions. While blood-brain barrier dysfunction appears early in the aging of the brain, and thus seems a good candidate for the position of primary causative mechanism, many studies – such as the one noted here – suggest that other pathologies assoc…
Tau Aggregation in the Aging Brain Causes Blood-Brain Barrier Dysfunction
The blood-brain barrier consists of specialized cells that line blood vessels passing through the central nervous system, only selectively allowing passage of molecules and cells between the circulation and the brain. Dysfunction of the blood-brain barrier allows unwanted molecules and cells into the brain, where they cause chronic inflammation and become an important contribution to the onset and progression of neurodegenerative conditions. While blood-brain barrier dysfunction appears early in the aging of the brain, and thus seems a good candidate for the position of primary causative mechanism, many studies – such as the one noted here – suggest that other pathologies assoc…