Researchers here provide evidence for 5 days of injections with 25-hydroxycholesterol to be senolytic in the vasculature of mice, reducing the harmful burden of senescent cells to reduce age-related aortic stiffness. There may be other mechanisms involved, but the researchers focused on clearance of senescent cells and the potential pathways by which this occurs in response to increased levels of 25-hydroxycholesterol. The comparison with the genetic model of senescent cell clearance is particularly interesting. Whether this treatment also provokes programmed cell death of senescent cells meaningfully in other tis…
Injected 25-Hydroxycholesterol is Senolytic in the Vasculature of Mice
Researchers here provide evidence for 5 days of injections with 25-hydroxycholesterol to be senolytic in the vasculature of mice, reducing the harmful burden of senescent cells to reduce age-related aortic stiffness. There may be other mechanisms involved, but the researchers focused on clearance of senescent cells and the potential pathways by which this occurs in response to increased levels of 25-hydroxycholesterol. The comparison with the genetic model of senescent cell clearance is particularly interesting. Whether this treatment also provokes programmed cell death of senescent cells meaningfully in other tis…