A Longevity-Reducing Genetic Variation that Replicates in Multiple Study Populations

Source https://www.fightaging.org/archives/2025/10/a-longevity-reducing-genetic-variation-that-replicates-in-multiple-study-populations/

Despite considerable effort, and the development of vast databases of genetic information, very few associations between specific genetic variants and longevity replicate across study populations, and the effect sizes are near all small. Based on the evidence to date, we should expect the genetic contribution to longevity to be small for most people, and across a population to be made up of tiny, conditional effects from thousands of gene variants. In this landscape, any new longevity-associated variant that occurs in multiple study populations is an unusual discovery worthy of note, even if the effect size is modest and it acts to reduce the odds of survival in later life.

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