Greater Inflammasome Induced IL-1β in Male Periodontitis May Drive Worse Pathology

Source https://www.fightaging.org/archives/2025/11/greater-inflammasome-induced-il-1%CE%B2-in-male-periodontitis-may-drive-worse-pathology/

Why does the inflammatory gum disease periodontitis tend to be worse in men versus women? As a possible answer to that question, researchers here demonstrate a sex difference in mammals in the inflammatory processes that drive the pathology of periodontitis. The condition progresses from chronic inflammation to bone loss and tooth loss, one example amongst many of the way in which unresolved inflammatory signaling changes the behavior of cells for the worse to cause disruption to tissue structure and function.

The inflammasome initiates inflammation via the maturation of interleukin-1 beta (IL-1β). Periodontitis is a prevalent, male-biased disease characterized by inflammation-driven bone loss, yet the mechanisms of this…

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