Source https://www.fightaging.org/archives/2025/11/car-t-therapy-targeting-oxidized-ldl-particles-slows-atherosclerotic-plaque-development-in-mice/
In studies in mice, it is much easier to show a slowing of atherosclerotic plaque growth over time than it is to show regression of existing plaque. Only a tiny number of approaches have shown any robust ability to regress obstructive plaque in the arteries once it has formed. Thus one should suspect that any new approach presented with data to show a slowing of plaque growth may not actually have the capacity to regress plaque – otherwise the researchers would have presented that much more desirable outcome instead.
Here, researchers turn the well established approach of engineering T cells to have chimeric antigen receptors to the problem of oxidized LDL particles. LDL particles carry cholesterol from the liver out into the body, and wh…
Source https://www.fightaging.org/archives/2025/11/car-t-therapy-targeting-oxidized-ldl-particles-slows-atherosclerotic-plaque-development-in-mice/
In studies in mice, it is much easier to show a slowing of atherosclerotic plaque growth over time than it is to show regression of existing plaque. Only a tiny number of approaches have shown any robust ability to regress obstructive plaque in the arteries once it has formed. Thus one should suspect that any new approach presented with data to show a slowing of plaque growth may not actually have the capacity to regress plaque – otherwise the researchers would have presented that much more desirable outcome instead.
Here, researchers turn the well established approach of engineering T cells to have chimeric antigen receptors to the problem of oxidized LDL particles. LDL particles carry cholesterol from the liver out into the body, and wh…
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