Source https://www.fightaging.org/archives/2025/11/molybdenum-disulfide-nanostructures-stimulate-mitochondrial-biogenesis-to-enhance-stem-cell-therapy-benefits/
One of the ways in which transplanted stem cells aid native cells in the short period of time before they die is by transferring mitochondria. This happens in much the same way as the cells also transfer signals via extracellular vesicles. A mitochondrion and a vesicle are both membrane-wrapped packages of molecules, albeit that the former is much more complex and functional. Mitochondria are important to cell function, as they generate the chemical energy store molecule adenosine triphosphate (ATP) required to power the cell.
Unfortunately, loss of mitochondrial function occurs with age, and is thought t…
Source https://www.fightaging.org/archives/2025/11/molybdenum-disulfide-nanostructures-stimulate-mitochondrial-biogenesis-to-enhance-stem-cell-therapy-benefits/
One of the ways in which transplanted stem cells aid native cells in the short period of time before they die is by transferring mitochondria. This happens in much the same way as the cells also transfer signals via extracellular vesicles. A mitochondrion and a vesicle are both membrane-wrapped packages of molecules, albeit that the former is much more complex and functional. Mitochondria are important to cell function, as they generate the chemical energy store molecule adenosine triphosphate (ATP) required to power the cell.
Unfortunately, loss of mitochondrial function occurs with age, and is thought t…
Source https://www.theminimalists.com/office/
Joshua speaks with a caller about setting up a new home office.
What does the perfect minimalist workspace look like? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post What does the perfect minimalist workspace look like? appeared first on The Minimalists.
…
Source https://www.theminimalists.com/office/
Joshua speaks with a caller about setting up a new home office.
What does the perfect minimalist workspace look like? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post What does the perfect minimalist workspace look like? appeared first on The Minimalists.
…
Source https://www.fightaging.org/archives/2025/11/car-t-therapy-targeting-oxidized-ldl-particles-slows-atherosclerotic-plaque-development-in-mice/
In studies in mice, it is much easier to show a slowing of atherosclerotic plaque growth over time than it is to show regression of existing plaque. Only a tiny number of approaches have shown any robust ability to regress obstructive plaque in the arteries once it has formed. Thus one should suspect that any new approach presented with data to show a slowing of plaque growth may not actually have the capacity to regress plaque – otherwise the researchers would have presented that much more desirable outcome instead.
Here, researchers turn the well established approach of engineering T cells to have chimeric antigen receptors to the problem of oxidized LDL particles. LDL particles carry cholesterol from the liver out into the body, and wh…
Source https://www.fightaging.org/archives/2025/11/car-t-therapy-targeting-oxidized-ldl-particles-slows-atherosclerotic-plaque-development-in-mice/
In studies in mice, it is much easier to show a slowing of atherosclerotic plaque growth over time than it is to show regression of existing plaque. Only a tiny number of approaches have shown any robust ability to regress obstructive plaque in the arteries once it has formed. Thus one should suspect that any new approach presented with data to show a slowing of plaque growth may not actually have the capacity to regress plaque – otherwise the researchers would have presented that much more desirable outcome instead.
Here, researchers turn the well established approach of engineering T cells to have chimeric antigen receptors to the problem of oxidized LDL particles. LDL particles carry cholesterol from the liver out into the body, and wh…
Source https://seniorplanet.org/articles-inspiring-jesse-meyers/
For years, Jesse Meyers, 90, has taught classes on James Joyce and his novel, Ulysses. Some 1,000 students later, Jesse has raised over $300,000 for charities through his classes and donated over 700 volumes on James Joyce to Fordham University.
The post Inspiring Story: Jesse Meyers’ Literary Passion appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-inspiring-jesse-meyers/
For years, Jesse Meyers, 90, has taught classes on James Joyce and his novel, Ulysses. Some 1,000 students later, Jesse has raised over $300,000 for charities through his classes and donated over 700 volumes on James Joyce to Fordham University.
The post Inspiring Story: Jesse Meyers’ Literary Passion appeared first on Senior Planet from AARP.
…
Source https://tinybuddha.com/blog/the-prowler-in-my-mind-learning-to-live-with-depression/
“There is a crack in everything, that’s how the light gets in.” ~Leonard Cohen
When depression comes, I feel it like a prowler gliding through my body. My chest tightens, my head fills with dark whispers, and even the day feels like night. The prowler has no face, no clear shape, but its presence is heavy. Sometimes it circles in silence within me. Other times it presses in until I don’t know how to respond.
In those moments, I feel caught between two choices: do I lie still, hoping it passes by, or do I rise and face it? Often, I choose lying down—not out of paralysis but patience. Sometimes the only way to coexist with the shadow is to rest, to surrender for a while, to let sleep take me. And someti…
Source https://tinybuddha.com/blog/the-prowler-in-my-mind-learning-to-live-with-depression/
“There is a crack in everything, that’s how the light gets in.” ~Leonard Cohen
When depression comes, I feel it like a prowler gliding through my body. My chest tightens, my head fills with dark whispers, and even the day feels like night. The prowler has no face, no clear shape, but its presence is heavy. Sometimes it circles in silence within me. Other times it presses in until I don’t know how to respond.
In those moments, I feel caught between two choices: do I lie still, hoping it passes by, or do I rise and face it? Often, I choose lying down—not out of paralysis but patience. Sometimes the only way to coexist with the shadow is to rest, to surrender for a while, to let sleep take me. And someti…
Source https://www.nerdfitness.com/blog/obligers/
Two words I hear all the time: motivation and accountability.
From clients, readers, and people who want to get healthier but can’t seem to make it stick.
While they sound simple, both are actually…complicated.
When someone says, “I just need more accountability,” what that really means can vary a lot.
- Sometimes it’s about systems and structure.
- <span style="font-weight:…
Source https://www.nerdfitness.com/blog/obligers/
Two words I hear all the time: motivation and accountability.
From clients, readers, and people who want to get healthier but can’t seem to make it stick.
While they sound simple, both are actually…complicated.
When someone says, “I just need more accountability,” what that really means can vary a lot.
- Sometimes it’s about systems and structure.
- <span style="font-weight:…
Source https://www.fightaging.org/archives/2025/11/inducing-greater-mitochondrial-respiratory-chain-supercomplex-formation-slows-aging-in-mice/
Every cell contains hundreds of mitochondria, a population of complex organelles that evolved from an ancient lineage of symbiotic bacteria that merged with early forms of cell to form the first eukaryotic cells. Mitochondria still act like bacteria in many ways, retaining a fragment of their original circular DNA, replicating by division, fusing together and passing around component parts, but are nonetheless now tightly integrated into cellular metabolism. Most mitochondrial genes have migrated into the cell nucleus, and a complex process of quality control known as mitophagy operates to recy…
Source https://www.fightaging.org/archives/2025/11/inducing-greater-mitochondrial-respiratory-chain-supercomplex-formation-slows-aging-in-mice/
Every cell contains hundreds of mitochondria, a population of complex organelles that evolved from an ancient lineage of symbiotic bacteria that merged with early forms of cell to form the first eukaryotic cells. Mitochondria still act like bacteria in many ways, retaining a fragment of their original circular DNA, replicating by division, fusing together and passing around component parts, but are nonetheless now tightly integrated into cellular metabolism. Most mitochondrial genes have migrated into the cell nucleus, and a complex process of quality control known as mitophagy operates to recy…
Source https://www.theminimalists.com/p515/
The Minimalists talk about celebrating the holidays without consumerism, our craziest Black Friday stories, the willingness to walk away from anything, six often-overlooked spaces in your home to declutter right now, and much more.
Listen to the Episode
Apple · Spotify · Patreon
Discussed in This Episode
- How does a minimalist enjoy the holidays without falling into the trap of consumerism?
- What’s your craziest Black Friday …
Source https://www.theminimalists.com/p515/
The Minimalists talk about celebrating the holidays without consumerism, our craziest Black Friday stories, the willingness to walk away from anything, six often-overlooked spaces in your home to declutter right now, and much more.
Listen to the Episode
Apple · Spotify · Patreon
Discussed in This Episode
- How does a minimalist enjoy the holidays without falling into the trap of consumerism?
- What’s your craziest Black Friday …
Source https://www.theminimalists.com/overlooked/
Joshua Millburn discusses six overlooked sources of clutter in the home.
What’s the most cluttered space in your home right now? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post 6 Often-Overlooked Spaces in Your Home to Declutter Right Now appeared first on The Minimalists.
…
Source https://www.theminimalists.com/overlooked/
Joshua Millburn discusses six overlooked sources of clutter in the home.
What’s the most cluttered space in your home right now? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post 6 Often-Overlooked Spaces in Your Home to Declutter Right Now appeared first on The Minimalists.
…