The Onset of Hypertension Causes Detrimental Changes in Cell Behavior Before Blood Pressure Increases

Source https://www.fightaging.org/archives/2025/11/the-onset-of-hypertension-causes-detrimental-changes-in-cell-behavior-before-blood-pressure-increases/

Hypertension is the name given to a state of high blood pressure. The onset of this condition typically progresses over time, as aging or lifestyle choices cause slowly increasing dysfunction in the systems of regulation and feedback that control blood pressure. A number of mechanisms are involved in determination of blood pressure, such as the kidney’s regulation of the volume of fluid in blood, the ability of blood vessels to contract and dilate to change the overall volume of the vascular system, and the pace at which the heart beats. The important processes of regulation are known as the renin-angiotensin-aldosterone system, in which signals pass back and forth from kidney to vasculature and other involved organs, including l…

Source https://www.fightaging.org/archives/2025/11/the-onset-of-hypertension-causes-detrimental-changes-in-cell-behavior-before-blood-pressure-increases/

Hypertension is the name given to a state of high blood pressure. The onset of this condition typically progresses over time, as aging or lifestyle choices cause slowly increasing dysfunction in the systems of regulation and feedback that control blood pressure. A number of mechanisms are involved in determination of blood pressure, such as the kidney’s regulation of the volume of fluid in blood, the ability of blood vessels to contract and dilate to change the overall volume of the vascular system, and the pace at which the heart beats. The important processes of regulation are known as the renin-angiotensin-aldosterone system, in which signals pass back and forth from kidney to vasculature and other involved organs, including l…

3 Surprising Causes of Burnout That Most People Miss

Source https://tinybuddha.com/blog/3-surprising-causes-of-burnout-that-most-people-miss/

“Love yourself first and everything else falls into line.” ~Lucille Ball

The first time I experienced burnout, I was twenty-six.

I was at the height of my career in London, doing it all, and yet I somehow found myself back at my parents’ house, sobbing in my mom’s car, after signing myself off from work, not having a clue how I landed there.

Burnout isn’t just about being tired from overexertion. It’s when we reach physical, mental, and emotional exhaustion after pushing ourselves past our capacity for too long.

When we finally stop, often against our will, all the confusing symptoms surface. We feel overwhelmed, out of control, like we’re go…

Source https://tinybuddha.com/blog/3-surprising-causes-of-burnout-that-most-people-miss/

“Love yourself first and everything else falls into line.” ~Lucille Ball

The first time I experienced burnout, I was twenty-six.

I was at the height of my career in London, doing it all, and yet I somehow found myself back at my parents’ house, sobbing in my mom’s car, after signing myself off from work, not having a clue how I landed there.

Burnout isn’t just about being tired from overexertion. It’s when we reach physical, mental, and emotional exhaustion after pushing ourselves past our capacity for too long.

When we finally stop, often against our will, all the confusing symptoms surface. We feel overwhelmed, out of control, like we’re go…

Get Social – and Become a Docent

Source https://seniorplanet.org/articles-social-docent/

Combine your enthusiasms and meet new people by becoming a guide or a docent at cultural showcases near you.

The post Get Social – and Become a Docent appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-social-docent/

Combine your enthusiasms and meet new people by becoming a guide or a docent at cultural showcases near you.

The post Get Social – and Become a Docent appeared first on Senior Planet from AARP.

Reviewing Cellular Senescence and Cell Therapy in Cardiovascular Disease

Source https://www.fightaging.org/archives/2025/11/reviewing-cellular-senescence-and-cell-therapy-in-cardiovascular-disease/

This is a very readable review, for all that the authors have stapled together two quite distinct topics into the one binder. Firstly, cellular senescence in various cell types in the cardiovascular system and its role in driving the onset and progression of cardiovascular disease. Secondly, efforts to develop cell therapies to treat cardiovascular disease, including the present generation of stem cell therapies that largely reduce inflammation without achieving any other goals, and further the attempts to induce regeneration and restoration of lost function by delivering replacement cells that are intended to survive, integrate, and support the age-damaged local cell po…

Source https://www.fightaging.org/archives/2025/11/reviewing-cellular-senescence-and-cell-therapy-in-cardiovascular-disease/

This is a very readable review, for all that the authors have stapled together two quite distinct topics into the one binder. Firstly, cellular senescence in various cell types in the cardiovascular system and its role in driving the onset and progression of cardiovascular disease. Secondly, efforts to develop cell therapies to treat cardiovascular disease, including the present generation of stem cell therapies that largely reduce inflammation without achieving any other goals, and further the attempts to induce regeneration and restoration of lost function by delivering replacement cells that are intended to survive, integrate, and support the age-damaged local cell po…

The Man Cave on…Creativity and Procrastination

Source https://seniorplanet.org/articles-man-cave-creativity/

Productivity – the ability to get things done, and the subsequent feeling of accomplishment and advancement – is directly linked to happiness.

The post The Man Cave on…Creativity and Procrastination appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-man-cave-creativity/

Productivity – the ability to get things done, and the subsequent feeling of accomplishment and advancement – is directly linked to happiness.

The post The Man Cave on…Creativity and Procrastination appeared first on Senior Planet from AARP.

Fight Aging! Newsletter, November 24th 2025

Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-24th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

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Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-24th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

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Increased Circulating Tyrosine Correlates with Slightly Shorter Lifespan in Men

Source https://www.fightaging.org/archives/2025/11/increased-circulating-tyrosine-correlates-with-slightly-shorter-lifespan-in-men/

A protein is a sequence of amino acids joined together to form a single molecule, and consequently amino acids are everywhere in our biochemistry. Their presence influences many processes, and the complexity of cellular biochemistry continues to ensure that relatively little of this is anywhere near completely mapped. Circulating amino acid levels, as measured in blood samples, have received more attention in the context of aging and longevity in recent years. There are a few hundred different amino acids beyond the twenty used to manufacture proteins, some of which must be obtained via diet as they are not synthesized by our biochemistry. Researchers have found a number of associations between specific amino acid levels and aging, as well as demonstrating that supplem…

Source https://www.fightaging.org/archives/2025/11/increased-circulating-tyrosine-correlates-with-slightly-shorter-lifespan-in-men/

A protein is a sequence of amino acids joined together to form a single molecule, and consequently amino acids are everywhere in our biochemistry. Their presence influences many processes, and the complexity of cellular biochemistry continues to ensure that relatively little of this is anywhere near completely mapped. Circulating amino acid levels, as measured in blood samples, have received more attention in the context of aging and longevity in recent years. There are a few hundred different amino acids beyond the twenty used to manufacture proteins, some of which must be obtained via diet as they are not synthesized by our biochemistry. Researchers have found a number of associations between specific amino acid levels and aging, as well as demonstrating that supplem…

When You’re Tired of Fixing Yourself: How to Stop Treating Healing Like a Full-Time Job

Source https://tinybuddha.com/blog/when-youre-tired-of-fixing-yourself-how-to-stop-treating-healing-like-a-full-time-job/

“True self-love is not about becoming someone better; it’s about softening into the truth of who you already are.” ~Yung Pueblo

One morning, I sat at my kitchen table with my journal open, a cup of green tea steaming beside me, and a stack of self-help books spread out like an emergency toolkit.

The sunlight was spilling across the counter, but I didn’t notice. My eyes kept darting between the dog-eared pages of a book called Becoming Your Best Self and the neatly written to-do list in my journal.

Meditation.
Gratitude journaling.
Affirmations.
Ten thousand steps.
Hydration tracker.
“Inner child work” …

Source https://tinybuddha.com/blog/when-youre-tired-of-fixing-yourself-how-to-stop-treating-healing-like-a-full-time-job/

“True self-love is not about becoming someone better; it’s about softening into the truth of who you already are.” ~Yung Pueblo

One morning, I sat at my kitchen table with my journal open, a cup of green tea steaming beside me, and a stack of self-help books spread out like an emergency toolkit.

The sunlight was spilling across the counter, but I didn’t notice. My eyes kept darting between the dog-eared pages of a book called Becoming Your Best Self and the neatly written to-do list in my journal.

Meditation.
Gratitude journaling.
Affirmations.
Ten thousand steps.
Hydration tracker.
“Inner child work” …

I Hate My Job

Source https://www.theminimalists.com/work/

T.K. Coleman talks about finding satisfaction in your work.

What’s the worst job you ever had? Let us know in the YouTube comments.

The post I Hate My Job appeared first on The Minimalists.

Source https://www.theminimalists.com/work/

T.K. Coleman talks about finding satisfaction in your work.

What’s the worst job you ever had? Let us know in the YouTube comments.

The post I Hate My Job appeared first on The Minimalists.

Understanding Mobile Phone Plans

Source https://seniorplanet.org/articles-mobile-phone-plans/

To pick a mobile phone plan, you have to consider which company that provides the mobile phone service and what plans they provide.

The post Understanding Mobile Phone Plans appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-mobile-phone-plans/

To pick a mobile phone plan, you have to consider which company that provides the mobile phone service and what plans they provide.

The post Understanding Mobile Phone Plans appeared first on Senior Planet from AARP.

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