Source https://tinybuddha.com/blog/the-2026-tiny-buddha-calendar-is-ready-for-holiday-gifting/
Hi friend! As we head into the holiday season, I know many of us are starting to think about gifts for the people we love (and maybe a few things for ourselves as well). With that in mind, I wanted to remind you that the 2026 Tiny Buddha Day-to-Day Calendar is now available.
It’s one of my favorite projects every year because I include the kind of daily reminders that I personally find validating, comforting, and encouraging—some from me, some from site contributors, and some from authors I enjoy. And as the number-one bestselling calendar in Mind-Body-Spirit for the past two years, I know it’s become an annual staple for lots of readers.
Featuring vibrant tear-off…
Podcast Ep. 514 | Guilty Pleasures
Source https://www.theminimalists.com/p514/
The Minimalists are reassessing guilty pleasures, reducing triggers that cause unnecessary pain, exploring annoying gifts, and much more.
Listen to the Episode
Discussed in This Episode
- How do I let go of guilt after I buy something that doesn’t align with my values?
- What’s one thing you feel guilty about having purchased?
- Right Here, Right Now: …
Source https://www.theminimalists.com/p514/
The Minimalists are reassessing guilty pleasures, reducing triggers that cause unnecessary pain, exploring annoying gifts, and much more.
Listen to the Episode
Discussed in This Episode
- How do I let go of guilt after I buy something that doesn’t align with my values?
- What’s one thing you feel guilty about having purchased?
- Right Here, Right Now: …
Lasting Epigenetic Changes Results from DNA Double Strand Break Repair
Gene expression is the complex process of producing proteins from a specific gene sequence encoded in DNA. The DNA in the nucleus of a cell is constantly surrounded by the machinery of gene expression. That machinery will attempt to start the process of transcription, the first step of gene expression, for any sequence it bumps into. Recall that every part of a cell is a chemical soup of molecules moving at incredible speeds, interacting with everything that they can possibly interact with, as fast as possible, countless times every second. Control over which genes are expressed at any given time is a matter of the structure of DNA, which sequences are exposed and which are spooled aroun…
Gene expression is the complex process of producing proteins from a specific gene sequence encoded in DNA. The DNA in the nucleus of a cell is constantly surrounded by the machinery of gene expression. That machinery will attempt to start the process of transcription, the first step of gene expression, for any sequence it bumps into. Recall that every part of a cell is a chemical soup of molecules moving at incredible speeds, interacting with everything that they can possibly interact with, as fast as possible, countless times every second. Control over which genes are expressed at any given time is a matter of the structure of DNA, which sequences are exposed and which are spooled aroun…
Ask Joan: Torn, Lost, Confused – and Scammed?
Source https://seniorplanet.org/articles-ask-joan-lost-confused/
Romance scam–or true love? A reader reaches out to Joan about a long-distance relationship.
The post Ask Joan: Torn, Lost, Confused – and Scammed? appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-ask-joan-lost-confused/
Romance scam–or true love? A reader reaches out to Joan about a long-distance relationship.
The post Ask Joan: Torn, Lost, Confused – and Scammed? appeared first on Senior Planet from AARP.
…
Half-Empty
Source https://www.theminimalists.com/half-empty/
By
A boy comes home from his first philosophy class.
He asks his mom: “Is the glass half empty or half full?”
She smiles. “It depends. Are you drinking, or are you pouring?”
<span style…
Source https://www.theminimalists.com/half-empty/
By
A boy comes home from his first philosophy class.
He asks his mom: “Is the glass half empty or half full?”
She smiles. “It depends. Are you drinking, or are you pouring?”
<span style…
Fight Aging! Newsletter, November 17th 2025
Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-17th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-17th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
You’re Both Idiots!
Source https://www.theminimalists.com/spiral/
T.K. Coleman talks about how to get out of an argument spiral.
What was the subject of your last argument? Let us know in the YouTube comments.
The post You’re Both Idiots! appeared first on The Minimalists.
…
Source https://www.theminimalists.com/spiral/
T.K. Coleman talks about how to get out of an argument spiral.
What was the subject of your last argument? Let us know in the YouTube comments.
The post You’re Both Idiots! appeared first on The Minimalists.
…
Open Thread: The End of Penny Candy
Source https://seniorplanet.org/articles-open-thread-penny-candy/
Goodbye Tootsie Rolls and Mary Janes! The end of the penny…and the end of penny candy.
The post Open Thread: The End of Penny Candy appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-open-thread-penny-candy/
Goodbye Tootsie Rolls and Mary Janes! The end of the penny…and the end of penny candy.
The post Open Thread: The End of Penny Candy appeared first on Senior Planet from AARP.
…
NADP in the Cell Cytosol Influences Vascular Aging
Source https://www.fightaging.org/archives/2025/11/nadp-in-the-cell-cytosol-influences-vascular-aging/
Nicotinamide adenine dinucleotide phosphate (NADP) has a different portfolio of functions in the cell to the better known nicotinamide adenine dinucleotide (NAD) that has been a focus for parts of the research community in recent years. NADP is thought to be primarily important as a defense against oxidative stress. Here, researchers discuss the role played by insufficient levels of NADP in vascular aging, finding that it encourages greater cellular senescence in the vascular endothelium, thus promoting endothelial dysfunction as a contribution to <a href="https://en.wikipe…
Source https://www.fightaging.org/archives/2025/11/nadp-in-the-cell-cytosol-influences-vascular-aging/
Nicotinamide adenine dinucleotide phosphate (NADP) has a different portfolio of functions in the cell to the better known nicotinamide adenine dinucleotide (NAD) that has been a focus for parts of the research community in recent years. NADP is thought to be primarily important as a defense against oxidative stress. Here, researchers discuss the role played by insufficient levels of NADP in vascular aging, finding that it encourages greater cellular senescence in the vascular endothelium, thus promoting endothelial dysfunction as a contribution to <a href="https://en.wikipe…
The Endothelial-to-Mesenchymal Transition in the Aging of the Brain's Vasculature
The aging of the blood vessels supplying the brain into a state of dysfunction provides an important contribution to the onset and progression of neurodegenerative conditions. There are many aspects to this vascular aging, including: loss of capillary density over time that reduces the ability of the vasculature to deliver sufficient nutrients to cells in brain tissue; the atherosclerosis that narrows and weakens major vessels with fatty deposits; the disruption of normal function of the endothelium, the inner layer of blood vessels; disruption of the normal function of the smooth muscle tha…
The aging of the blood vessels supplying the brain into a state of dysfunction provides an important contribution to the onset and progression of neurodegenerative conditions. There are many aspects to this vascular aging, including: loss of capillary density over time that reduces the ability of the vasculature to deliver sufficient nutrients to cells in brain tissue; the atherosclerosis that narrows and weakens major vessels with fatty deposits; the disruption of normal function of the endothelium, the inner layer of blood vessels; disruption of the normal function of the smooth muscle tha…