Source https://www.fightaging.org/archives/2025/10/degeneration-of-the-tectorial-membrane-in-age-related-hearing-loss/
Researchers here propose a novel form of damage and dysfunction contributing to the development of age-related hearing loss. Much of the focus of past years of research has been placed upon loss of connectivity between sensory hair cells of the inner ear and the brain, or outright loss of hair cells themselves. But there are other components of the overall problem of loss of function, as noted here, and the question of what to do about it doesn’t always have as straightforward a path towards practical therapies as exists for loss of cells.
Age-related hearing loss is common among older adults and can result from several problems in the inner ear. The disorder is usually classified into three types: (a) Neural: due to damage to auditory nerve fibres, (b) Sensory: caused by the loss of the s…
Source https://www.fightaging.org/archives/2025/10/degeneration-of-the-tectorial-membrane-in-age-related-hearing-loss/
Researchers here propose a novel form of damage and dysfunction contributing to the development of age-related hearing loss. Much of the focus of past years of research has been placed upon loss of connectivity between sensory hair cells of the inner ear and the brain, or outright loss of hair cells themselves. But there are other components of the overall problem of loss of function, as noted here, and the question of what to do about it doesn’t always have as straightforward a path towards practical therapies as exists for loss of cells.
Age-related hearing loss is common among older adults and can result from several problems in the inner ear. The disorder is usually classified into three types: (a) Neural: due to damage to auditory nerve fibres, (b) Sensory: caused by the loss of the s…
Source https://www.theminimalists.com/no/
T.K. Coleman discusses five strategies for saying no without guilt.
How do you say no? Let us know in the YouTube comments.
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email.
The post Just Say No appeared first on The Minimalists.
…
Source https://www.theminimalists.com/no/
T.K. Coleman discusses five strategies for saying no without guilt.
How do you say no? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post Just Say No appeared first on The Minimalists.
…
Source https://www.fightaging.org/archives/2025/10/the-role-of-mitochondrial-dysfunction-in-sarcopenia/
The hundreds of mitochondria present in every cell work to produce the chemical energy store molecule adenosine triphosphate (ATP), necessary for cell function. With age, some combination of damage to mitochondrial DNA and changes in the epigenetic control of gene expression act to degrade mitochondrial ATP production and otherwise ensure that mitochondria function progressively less effectively. This stresses cells and negatively affects tissue function. Here, researchers review what is known of mitochondrial loss of function in muscle tissue, leading to the characteristic loss of muscle mass and strength that occurs with aging and leads to <a href="https://en.wikipedia.org/wiki/Sar…
Source https://www.fightaging.org/archives/2025/10/the-role-of-mitochondrial-dysfunction-in-sarcopenia/
The hundreds of mitochondria present in every cell work to produce the chemical energy store molecule adenosine triphosphate (ATP), necessary for cell function. With age, some combination of damage to mitochondrial DNA and changes in the epigenetic control of gene expression act to degrade mitochondrial ATP production and otherwise ensure that mitochondria function progressively less effectively. This stresses cells and negatively affects tissue function. Here, researchers review what is known of mitochondrial loss of function in muscle tissue, leading to the characteristic loss of muscle mass and strength that occurs with aging and leads to <a href="https://en.wikipedia.org/wiki/Sar…
Source https://www.fightaging.org/archives/2025/10/incompletely-understood-changes-in-immunoglobulins-take-place-with-age/
Immunoglobulin proteins are also known as antibodies, and can circulate freely or be bound to cell surfaces. They serve to tag specific structures for recognition and attack by the immune system, so a very broad range of variants on the basic structure are manufactured by plasma cells derived from B cells in response to the presence of immune-provoking antigens. These immunoglobulins then go on to shape the behavior of the immune system as a whole. Here, researchers take a tour of what is known of age-related changes in immunoglobulins, an area of study in which all too little is completely mapped or understood. To understand what is observed, one would hav…
Source https://www.fightaging.org/archives/2025/10/incompletely-understood-changes-in-immunoglobulins-take-place-with-age/
Immunoglobulin proteins are also known as antibodies, and can circulate freely or be bound to cell surfaces. They serve to tag specific structures for recognition and attack by the immune system, so a very broad range of variants on the basic structure are manufactured by plasma cells derived from B cells in response to the presence of immune-provoking antigens. These immunoglobulins then go on to shape the behavior of the immune system as a whole. Here, researchers take a tour of what is known of age-related changes in immunoglobulins, an area of study in which all too little is completely mapped or understood. To understand what is observed, one would hav…
Source https://www.fightaging.org/archives/2025/10/human-umbilical-cord-mesenchymal-stem-cell-transplantation-as-a-senomorphic-therapy/
Today’s open access paper links a number of different areas of research and development of interest. Firstly, that senescent cells accumulate with age to disrupt tissue structure and function with their inflammatory secretions. Secondly, that the innate immune cells known as microglia become overly active and inflammatory in the aging brain, and a growing body of evidence supports a significant role for these inflammatory microglia in the development of neurodegenerative conditions. Some of these inflammatory microglia are senescent. Thirdly, the stem cell therapies pioneered over the last thirty years, and the mo…
Source https://www.fightaging.org/archives/2025/10/human-umbilical-cord-mesenchymal-stem-cell-transplantation-as-a-senomorphic-therapy/
Today’s open access paper links a number of different areas of research and development of interest. Firstly, that senescent cells accumulate with age to disrupt tissue structure and function with their inflammatory secretions. Secondly, that the innate immune cells known as microglia become overly active and inflammatory in the aging brain, and a growing body of evidence supports a significant role for these inflammatory microglia in the development of neurodegenerative conditions. Some of these inflammatory microglia are senescent. Thirdly, the stem cell therapies pioneered over the last thirty years, and the mo…
Source https://tinybuddha.com/blog/the-hidden-lesson-in-projection-its-never-really-about-us/
“What others say and do is a projection of their own reality, their own dream. When you are immune to the opinions and actions of others, you won’t be the victim of needless suffering.” ~Don Miguel Ruiz
For most of my life, I didn’t fully understand what projection was. I just knew I kept becoming the problem.
I was “too much.” Too intense. Too emotional. Thought too deeply. Spoke too plainly.
Again and again, I was blamed, misunderstood, and cast out for holding up a mirror to things no one wanted to see.
But in my forties, I began doing shadow work in and out of therapy. At first, I thought the shadow was the broken part. The mess to fix. Th…
Source https://tinybuddha.com/blog/the-hidden-lesson-in-projection-its-never-really-about-us/
“What others say and do is a projection of their own reality, their own dream. When you are immune to the opinions and actions of others, you won’t be the victim of needless suffering.” ~Don Miguel Ruiz
For most of my life, I didn’t fully understand what projection was. I just knew I kept becoming the problem.
I was “too much.” Too intense. Too emotional. Thought too deeply. Spoke too plainly.
Again and again, I was blamed, misunderstood, and cast out for holding up a mirror to things no one wanted to see.
But in my forties, I began doing shadow work in and out of therapy. At first, I thought the shadow was the broken part. The mess to fix. Th…
Source https://tinybuddha.com/blog/the-lonely-ache-of-self-worth-that-no-one-talks-about/
“The deeper that sorrow carves into your being, the more joy you can contain.” ~Kahlil Gibran
They don’t talk about this part.
The hardest part about knowing your worth—after doing the work, setting boundaries, and getting crystal clear on what you want—is the ache.
Not just any ache. The ache of being awake. The ache of knowing. The ache of not settling.
I remember the first time I walked away from someone who didn’t mistreat me but who also didn’t quite meet me. I had spent years unraveling my old patterns: the people-pleasing, the over-giving,…
Source https://tinybuddha.com/blog/the-lonely-ache-of-self-worth-that-no-one-talks-about/
“The deeper that sorrow carves into your being, the more joy you can contain.” ~Kahlil Gibran
They don’t talk about this part.
The hardest part about knowing your worth—after doing the work, setting boundaries, and getting crystal clear on what you want—is the ache.
Not just any ache. The ache of being awake. The ache of knowing. The ache of not settling.
I remember the first time I walked away from someone who didn’t mistreat me but who also didn’t quite meet me. I had spent years unraveling my old patterns: the people-pleasing, the over-giving,…
Source https://www.fightaging.org/archives/2025/10/more-evidence-for-impaired-cerebrospinal-fluid-drainage-to-contribute-to-neurodegeneration/
While the biochemistry of the brain is segregated from the biochemistry of the rest of the body by the blood-brain barrier, a lining of specialized cells wrapping blood vessels that pass through the brain, large amounts of cerebrospinal fluid flow through the brain and exit into the body, carrying away metabolic waste. The major known pathways include (a) channels in the bone of the cribriform plate that drain the olfactory bulb region of the brain, and (b) the glymphatic system that is made up of fluid filled channels that parallel blood vessels where they enter and exit the brain. Both of these pathways decline in efficiency with age: the cribriform plate channels ossify and…
Source https://www.fightaging.org/archives/2025/10/more-evidence-for-impaired-cerebrospinal-fluid-drainage-to-contribute-to-neurodegeneration/
While the biochemistry of the brain is segregated from the biochemistry of the rest of the body by the blood-brain barrier, a lining of specialized cells wrapping blood vessels that pass through the brain, large amounts of cerebrospinal fluid flow through the brain and exit into the body, carrying away metabolic waste. The major known pathways include (a) channels in the bone of the cribriform plate that drain the olfactory bulb region of the brain, and (b) the glymphatic system that is made up of fluid filled channels that parallel blood vessels where they enter and exit the brain. Both of these pathways decline in efficiency with age: the cribriform plate channels ossify and…
Source https://www.theminimalists.com/ownership/
The Minimalists speak with Ryan Holiday about the idea of living out of a suitcase.
Could you live out of just a suitcase? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post The Ego of Ownership appeared first on The Minimalists.
…
Source https://www.theminimalists.com/ownership/
The Minimalists speak with Ryan Holiday about the idea of living out of a suitcase.
Could you live out of just a suitcase? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post The Ego of Ownership appeared first on The Minimalists.
…
Source https://tinybuddha.com/blog/the-great-horned-owl-that-kicked-me-out-of-burnout/
“When I let go of what I am, I become what I might be.” ~Lao Tzu
I’d known for months that I was burned out.
The kind of burnout that creeps in quietly—behind your eyes, in your spine, in your calendar. I was volunteering in raptor rescue, monitoring eagle nests as the busy season ramped up, juggling consulting work, supporting adoption placements, writing, creating. I was showing up fully in every space except the one I lived in: my body.
And yet I refused to let go. I told myself it was just a busy season. That i…
Source https://tinybuddha.com/blog/the-great-horned-owl-that-kicked-me-out-of-burnout/
“When I let go of what I am, I become what I might be.” ~Lao Tzu
I’d known for months that I was burned out.
The kind of burnout that creeps in quietly—behind your eyes, in your spine, in your calendar. I was volunteering in raptor rescue, monitoring eagle nests as the busy season ramped up, juggling consulting work, supporting adoption placements, writing, creating. I was showing up fully in every space except the one I lived in: my body.
And yet I refused to let go. I told myself it was just a busy season. That i…