Source https://www.fightaging.org/archives/2025/10/potential-targets-to-enhance-the-regenerative-capacity-of-alveolar-type-2-cells-in-the-lungs/
Researchers here report on potential targets to enhance the regenerative capacity of alveolar type 2 cells, a population necessary for regeneration in lung tissue, but which falters in this duty in the context of progressive and age-related lung disease. Compensating for poorly understood mechanisms of damage and disease that direct alveolar type 2 cells away from regenerative activity can in principle be achieved by overriding the regulatory system that controls this aspect of cell behavior, provided enough is understood of how that regulatory system works. This approach to therapy doesn’t fix the underlying issues, but may well prove to be beneficial enough to pursue. There are numerous examples in the present practice of medicine of compensatory approaches that succeed in producing benefits for patients.
When a person’s lungs are damaged, that organ’s survival depends on a small but powerful set o…
Source https://www.fightaging.org/archives/2025/10/potential-targets-to-enhance-the-regenerative-capacity-of-alveolar-type-2-cells-in-the-lungs/
Researchers here report on potential targets to enhance the regenerative capacity of alveolar type 2 cells, a population necessary for regeneration in lung tissue, but which falters in this duty in the context of progressive and age-related lung disease. Compensating for poorly understood mechanisms of damage and disease that direct alveolar type 2 cells away from regenerative activity can in principle be achieved by overriding the regulatory system that controls this aspect of cell behavior, provided enough is understood of how that regulatory system works. This approach to therapy doesn’t fix the underlying issues, but may well prove to be beneficial enough to pursue. There are numerous examples in the present practice of medicine of compensatory approaches that succeed in producing benefits for patients.
When a person’s lungs are damaged, that organ’s survival depends on a small but powerful set o…
Source https://tinybuddha.com/blog/a-quiet-but-powerful-shift-how-slowing-down-transformed-my-life/
“Slow down and enjoy life. It’s not only the scenery you miss by going too fast—you also miss the sense of where you are going and why.” ~Eddie Cantor
In today’s hyper-connected and fast-paced world, slowing down isn’t just rare—it feels almost countercultural.
For years, I tied my identity to productivity. My self-worth hinged on how much I could accomplish in a day, how many boxes I could check. The busier I was, the more valuable I believed myself to be. But that constant need to perform left me mentally and emotionally drained, disconnected not only from others but from myself.
The shift didn…
Source https://tinybuddha.com/blog/a-quiet-but-powerful-shift-how-slowing-down-transformed-my-life/
“Slow down and enjoy life. It’s not only the scenery you miss by going too fast—you also miss the sense of where you are going and why.” ~Eddie Cantor
In today’s hyper-connected and fast-paced world, slowing down isn’t just rare—it feels almost countercultural.
For years, I tied my identity to productivity. My self-worth hinged on how much I could accomplish in a day, how many boxes I could check. The busier I was, the more valuable I believed myself to be. But that constant need to perform left me mentally and emotionally drained, disconnected not only from others but from myself.
The shift didn…
Source https://www.fightaging.org/archives/2025/10/increased-fmo3-expression-to-generate-more-tmao-is-a-part-of-harmful-adipose-tissue-aging/
A number of lines of research indicate that fat tissue becomes actively harmful to other tissues with advancing age via forms of signaling. Much of this work is focused on the role of excess visceral fat tissue in long-term health. Visceral fat acts to increase the burden of senescent cells, which then promote inflammation throughout the body via inflammatory signaling, but fat cells can also act to directly generate pro-inflammatory signaling in other ways, such as via mimicking the signaling generated by infected cells. These are not the …
Source https://www.fightaging.org/archives/2025/10/increased-fmo3-expression-to-generate-more-tmao-is-a-part-of-harmful-adipose-tissue-aging/
A number of lines of research indicate that fat tissue becomes actively harmful to other tissues with advancing age via forms of signaling. Much of this work is focused on the role of excess visceral fat tissue in long-term health. Visceral fat acts to increase the burden of senescent cells, which then promote inflammation throughout the body via inflammatory signaling, but fat cells can also act to directly generate pro-inflammatory signaling in other ways, such as via mimicking the signaling generated by infected cells. These are not the …
Source https://www.fightaging.org/archives/2025/10/visceral-fat-correlates-with-progression-of-atherosclerosis/
The more visceral fat that is present in the body, the greater the burden of atherosclerotic plaque narrowing and weakening major blood vessels. This isn’t just for those people who are very overweight, but the data shows that any degree of excess visceral fat correlates with a relative degree of acceleration of atherosclerosis: the more fat the worse the outcome. Visceral fat also contributes to other age-related conditions, with the most likely link being promotion of chronic inflammation via a number of different mechanisms. Visceral fat tissue promotes a greater burden of cellular senescence, fat ce…
Source https://www.fightaging.org/archives/2025/10/visceral-fat-correlates-with-progression-of-atherosclerosis/
The more visceral fat that is present in the body, the greater the burden of atherosclerotic plaque narrowing and weakening major blood vessels. This isn’t just for those people who are very overweight, but the data shows that any degree of excess visceral fat correlates with a relative degree of acceleration of atherosclerosis: the more fat the worse the outcome. Visceral fat also contributes to other age-related conditions, with the most likely link being promotion of chronic inflammation via a number of different mechanisms. Visceral fat tissue promotes a greater burden of cellular senescence, fat ce…
Source https://tinybuddha.com/blog/you-dont-have-to-be-strong-all-the-time/
“Sometimes the strongest thing you can do is to ask for help.” ~Unknown
We live in a world that praises strength—especially quiet strength. The kind that shows up, gets things done, and rarely complains. The kind that’s resilient, dependable, productive. But what happens when the strong one quietly breaks inside?
“You are a superwoman!”
“You’re so reliable!”
“You’re the glue that holds everyone together.”
I wore those compliments like badges of honor. For years, I believed them. Not just believed them—I built my ide…
Source https://tinybuddha.com/blog/you-dont-have-to-be-strong-all-the-time/
“Sometimes the strongest thing you can do is to ask for help.” ~Unknown
We live in a world that praises strength—especially quiet strength. The kind that shows up, gets things done, and rarely complains. The kind that’s resilient, dependable, productive. But what happens when the strong one quietly breaks inside?
“You are a superwoman!”
“You’re so reliable!”
“You’re the glue that holds everyone together.”
I wore those compliments like badges of honor. For years, I believed them. Not just believed them—I built my ide…
Source https://www.theminimalists.com/regrets/
The Minimalists discuss common regrets people have after letting go.
What’s one item you regret decluttering? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post 7 Things People Regret Tossing While Decluttering appeared first on The Minimalists.
…
Source https://www.theminimalists.com/regrets/
The Minimalists discuss common regrets people have after letting go.
What’s one item you regret decluttering? Let us know in the YouTube comments.
Subscribe to The Minimalists via
email.
The post 7 Things People Regret Tossing While Decluttering appeared first on The Minimalists.
…
Source https://www.fightaging.org/archives/2025/10/lower-circulating-bdnf-level-correlates-with-greater-cognitive-decline/
A range of research suggests that an increase in the circulating levels of BDNF is beneficial to the function of the brain (and likely muscle tissue as well). This is one of the ways in which alterations to the diet and gut microbiome composition can affect the brain, as microbial production of butyrate via fermentation of dietary fiber acts to increase BDNF expression. The research community has an interest in finding other ways to increase BDNF levels more directly, and that is a work in progress. Meanwhile, researchers continue to produce evidence t…
Source https://www.fightaging.org/archives/2025/10/lower-circulating-bdnf-level-correlates-with-greater-cognitive-decline/
A range of research suggests that an increase in the circulating levels of BDNF is beneficial to the function of the brain (and likely muscle tissue as well). This is one of the ways in which alterations to the diet and gut microbiome composition can affect the brain, as microbial production of butyrate via fermentation of dietary fiber acts to increase BDNF expression. The research community has an interest in finding other ways to increase BDNF levels more directly, and that is a work in progress. Meanwhile, researchers continue to produce evidence t…
Source https://www.fightaging.org/archives/2025/10/exploring-alternative-splicing-as-a-determinant-of-species-life-span/
A gene coding for a protein consists of multiple exon and intron sequences of DNA. During gene expression, the full DNA sequence of exons and introns is first transcribed into a RNA sequence, the primary transcript. That primary transcript undergoes a series of alterations that include RNA splicing. This splicing process removes the introns and stitches together the remaining exons to form a me…
Source https://www.fightaging.org/archives/2025/10/exploring-alternative-splicing-as-a-determinant-of-species-life-span/
A gene coding for a protein consists of multiple exon and intron sequences of DNA. During gene expression, the full DNA sequence of exons and introns is first transcribed into a RNA sequence, the primary transcript. That primary transcript undergoes a series of alterations that include RNA splicing. This splicing process removes the introns and stitches together the remaining exons to form a me…
Source https://seniorplanet.org/articles-financial-orphan-retirees/
More Americans are aging alone, without spouses or any close family members. These “orphan retirees” face special financial challenges.
The post Financial Planning for “Orphan Retirees” appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-financial-orphan-retirees/
More Americans are aging alone, without spouses or any close family members. These “orphan retirees” face special financial challenges.
The post Financial Planning for “Orphan Retirees” appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/10/reviewing-the-development-of-senolytic-therapies-for-neurodegenerative-conditions/
Senescent cells accumulate with age in tissues throughout the body, generating sustained pro-inflammatory signaling that is increasingly disruptive to tissue structure and function. This is an important contribution to degenerative aging, as illustrated by the many animal studies in which senolytic therapies that selectively destroy senescent cells produce significant reversal of aspects of aging and age-related disease. Here, researchers review the evidence for senolytic therapies to effectively treat neurodegenerative conditions by removing the harms done by senescent cells in the brain.
<blockquo…
Source https://www.fightaging.org/archives/2025/10/reviewing-the-development-of-senolytic-therapies-for-neurodegenerative-conditions/
Senescent cells accumulate with age in tissues throughout the body, generating sustained pro-inflammatory signaling that is increasingly disruptive to tissue structure and function. This is an important contribution to degenerative aging, as illustrated by the many animal studies in which senolytic therapies that selectively destroy senescent cells produce significant reversal of aspects of aging and age-related disease. Here, researchers review the evidence for senolytic therapies to effectively treat neurodegenerative conditions by removing the harms done by senescent cells in the brain.
<blockquo…