Source https://www.fightaging.org/archives/2025/10/pharmacological-approaches-to-the-treatment-of-skeletal-muscle-aging/
Researchers here provide a tour of better known pharmacological targets for the development of drugs to slow or potentially reverse loss of muscle mass and strength with age. The high bar to beat is the effects of resistance exercise, but there is likely merit in drugs that will enhance the improvements provided by resistance exercise, provided that they have a reasonable cost. A few common themes emerge in the targets. Many approaches produce a reduction in inflammation, as chronic inflammation is strongly implicated in loss of muscle tissue maintenance and tissue function, for example. Loss of stem cell activity and issues with neuromuscular junctions are also well studied in the context of muscle aging, and the research community has sou…
Source https://www.fightaging.org/archives/2025/10/pharmacological-approaches-to-the-treatment-of-skeletal-muscle-aging/
Researchers here provide a tour of better known pharmacological targets for the development of drugs to slow or potentially reverse loss of muscle mass and strength with age. The high bar to beat is the effects of resistance exercise, but there is likely merit in drugs that will enhance the improvements provided by resistance exercise, provided that they have a reasonable cost. A few common themes emerge in the targets. Many approaches produce a reduction in inflammation, as chronic inflammation is strongly implicated in loss of muscle tissue maintenance and tissue function, for example. Loss of stem cell activity and issues with neuromuscular junctions are also well studied in the context of muscle aging, and the research community has sou…
Source https://tinybuddha.com/blog/full-circle-reclaiming-the-me-i-thought-id-lost/
“We shall not cease from exploration, and the end of all our exploring will be to arrive where we started and know the place for the first time.” ~T.S. Eliot
In my early twenties, I packed a backpack and boarded a plane alone with a one-way ticket to Southeast Asia. It was a move that baffled my father, inspired my friends, and quietly terrified me.
I was drawn by something I couldn’t fully articulate at the time: a craving for freedom, truth, and a kind of belonging I hadn’t yet known. What I didn’t realize then is that this two-year trip would imprint on me a version of myself I’d spend the next twenty years slowly forgetting, and then, almost by surprise, begin to reclaim.
Th…
Source https://tinybuddha.com/blog/full-circle-reclaiming-the-me-i-thought-id-lost/
“We shall not cease from exploration, and the end of all our exploring will be to arrive where we started and know the place for the first time.” ~T.S. Eliot
In my early twenties, I packed a backpack and boarded a plane alone with a one-way ticket to Southeast Asia. It was a move that baffled my father, inspired my friends, and quietly terrified me.
I was drawn by something I couldn’t fully articulate at the time: a craving for freedom, truth, and a kind of belonging I hadn’t yet known. What I didn’t realize then is that this two-year trip would imprint on me a version of myself I’d spend the next twenty years slowly forgetting, and then, almost by surprise, begin to reclaim.
Th…
Source https://www.theminimalists.com/p509/
The Minimalists talk about feeling defeated because of limitations, problems that won’t go away, other people’s cluttered spaces, five things you should never feel guilty about getting rid of, and more!
Listen to the Episode
Apple · Spotify · Patreon
Discussed in This Episode
- How do you cope when a recurring injury or limitation makes you feel defeated, anxious, and discouraged?
- What problem keeps popping up even after y…
Source https://www.theminimalists.com/p509/
The Minimalists talk about feeling defeated because of limitations, problems that won’t go away, other people’s cluttered spaces, five things you should never feel guilty about getting rid of, and more!
Listen to the Episode
Apple · Spotify · Patreon
Discussed in This Episode
- How do you cope when a recurring injury or limitation makes you feel defeated, anxious, and discouraged?
- What problem keeps popping up even after y…
Source https://seniorplanet.org/articles-senior-debt/
Debt among Americans going into retirement is reaching alarmingly high levels – are you one of the four in ten at high risk?
The post The Senior Debt Trap appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-senior-debt/
Debt among Americans going into retirement is reaching alarmingly high levels – are you one of the four in ten at high risk?
The post The Senior Debt Trap appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/10/a-25-component-blood-biomarker-aging-clock-improves-on-9-component-phenoage/
PhenoAge is an aging clock derived from patient data on age-related changes in nine clinical chemistry markers that are easily measured via a blood sample. A number of other blood biomarker clocks have been proposed that use more markers. The clock noted here claims a modest improvement over PhenoAge when it comes to predicting mortality risk, but that requires 25 markers. The trade-off is in the cost to the patient to obtain the necessary assays versus the degree of improved performance of the clock. This tends to be true across clocks more generally, regardless of the data used. The more popular clocks based on fewer measures continue to be popular because they do not greatly underperform the more expensive clocks that require many more measures. The work here reproduces that result by showing that combining a su…
Source https://www.fightaging.org/archives/2025/10/a-25-component-blood-biomarker-aging-clock-improves-on-9-component-phenoage/
PhenoAge is an aging clock derived from patient data on age-related changes in nine clinical chemistry markers that are easily measured via a blood sample. A number of other blood biomarker clocks have been proposed that use more markers. The clock noted here claims a modest improvement over PhenoAge when it comes to predicting mortality risk, but that requires 25 markers. The trade-off is in the cost to the patient to obtain the necessary assays versus the degree of improved performance of the clock. This tends to be true across clocks more generally, regardless of the data used. The more popular clocks based on fewer measures continue to be popular because they do not greatly underperform the more expensive clocks that require many more measures. The work here reproduces that result by showing that combining a su…
Source https://www.fightaging.org/archives/2025/10/egcg-targeted-to-muscle-cells-enhances-muscle-function-in-aged-mice/
Treatments that cause issues when administered systemically (such as via oral ingestion or intravenous injection) at the doses required to place enough of the therapeutic in a specific location in the body can be made practical via methods targeting delivery to specific cells. Here, researchers use liposomes attached to a muscle-targeted peptide to deliver the polyphenol epigallocatechin gallate (EGCG) to muscle cells. EGCG is otherwise problematic, causing liver toxicity at high doses, and has low bioavailability when ingested. Nonetheless it does have interesting effects on inflammation, <a href="https://en.wikipedia.org/wiki/Lipid_…
Source https://www.fightaging.org/archives/2025/10/egcg-targeted-to-muscle-cells-enhances-muscle-function-in-aged-mice/
Treatments that cause issues when administered systemically (such as via oral ingestion or intravenous injection) at the doses required to place enough of the therapeutic in a specific location in the body can be made practical via methods targeting delivery to specific cells. Here, researchers use liposomes attached to a muscle-targeted peptide to deliver the polyphenol epigallocatechin gallate (EGCG) to muscle cells. EGCG is otherwise problematic, causing liver toxicity at high doses, and has low bioavailability when ingested. Nonetheless it does have interesting effects on inflammation, <a href="https://en.wikipedia.org/wiki/Lipid_…
Source https://seniorplanet.org/articles-es-conozca-a-la-representante-de-la-linea-directa-nita-flores/
La representante de la línea directa de Senior Planet, Nita, es una residente de Brooklyn que conduce un pódcast de ciencia ficción y disfruta ayudar a las personas mayores a adoptar nuevas tecnologías.
The post Conozca a la representante de la línea directa: Nita Flores appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-es-conozca-a-la-representante-de-la-linea-directa-nita-flores/
La representante de la línea directa de Senior Planet, Nita, es una residente de Brooklyn que conduce un pódcast de ciencia ficción y disfruta ayudar a las personas mayores a adoptar nuevas tecnologías.
The post Conozca a la representante de la línea directa: Nita Flores appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/play-october-building-community/
Ready to test your skills? This month’s theme, Building Community, celebrates the power of connection with clues about friendship, teamwork, and coming together.
The post Play October: Building Community appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/play-october-building-community/
Ready to test your skills? This month’s theme, Building Community, celebrates the power of connection with clues about friendship, teamwork, and coming together.
The post Play October: Building Community appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/10/fight-aging-newsletter-october-13th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
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Source https://www.fightaging.org/archives/2025/10/fight-aging-newsletter-october-13th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
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