Source https://www.fightaging.org/archives/2022/08/a-modest-gain-in-mouse-lifespan-via-pharmacological-means-of-cisd2-upregulation/
The usual progression of ways to tinker with metabolism in order to affect the pace of aging is much as follows: (a) identify an interesting mechanism associated with a single gene; (b) create mouse lineages in which the expression of this gene is manipulated in a controlled way via genetic engineering, to observe the outcomes; (c) use some form of gene therapy to overexpress or knock down that gene in mice, and note differences in life span and manifestations of aging; (d) search the drug databases for small molecules that might affect expression of the gen…
Source https://www.fightaging.org/archives/2022/08/a-modest-gain-in-mouse-lifespan-via-pharmacological-means-of-cisd2-upregulation/
The usual progression of ways to tinker with metabolism in order to affect the pace of aging is much as follows: (a) identify an interesting mechanism associated with a single gene; (b) create mouse lineages in which the expression of this gene is manipulated in a controlled way via genetic engineering, to observe the outcomes; (c) use some form of gene therapy to overexpress or knock down that gene in mice, and note differences in life span and manifestations of aging; (d) search the drug databases for small molecules that might affect expression of the gen…
Source https://minimalistbaker.com/grilled-teriyaki-tofu-skewers/
Is it even summertime without a skewer?! We think not. These teriyaki tofu skewers are full of savory sweet goodness, and when grilled, they develop a subtly crusty exterior and perfectly smoky taste. It’s safe to say this recipe’s a winner, friends!
We love these skewers alongside a cold sesame noodle salad or stir-fry for a protein-packed, plant-based summer meal! Just 9 ingredients required for these super flavorful tofu skewers.
<a href="https://minimalistbaker.com/grilled-teri…
Source https://minimalistbaker.com/grilled-teriyaki-tofu-skewers/
Is it even summertime without a skewer?! We think not. These teriyaki tofu skewers are full of savory sweet goodness, and when grilled, they develop a subtly crusty exterior and perfectly smoky taste. It’s safe to say this recipe’s a winner, friends!
We love these skewers alongside a cold sesame noodle salad or stir-fry for a protein-packed, plant-based summer meal! Just 9 ingredients required for these super flavorful tofu skewers.
<a href="https://minimalistbaker.com/grilled-teri…
Source https://minimalistbaker.com/grilled-teriyaki-chicken-skewers-quick-marinating/
Dry, flavorless chicken and lengthy marinating times? Those are things of the past, friends. These quick-marinating grilled teriyaki chicken skewers are incredibly flavorful and bursting with umami and salty-sweet perfection!
We love these satisfying skewers with noodle salads, stir-fries, grilled veggies, or served simply with rice and steamed broccoli! Bonus? They come together quickly with 9 ingredients you probably have around. Let us show you how it’s done!
How to Make Grilled Te…
Source https://minimalistbaker.com/grilled-teriyaki-chicken-skewers-quick-marinating/
Dry, flavorless chicken and lengthy marinating times? Those are things of the past, friends. These quick-marinating grilled teriyaki chicken skewers are incredibly flavorful and bursting with umami and salty-sweet perfection!
We love these satisfying skewers with noodle salads, stir-fries, grilled veggies, or served simply with rice and steamed broccoli! Bonus? They come together quickly with 9 ingredients you probably have around. Let us show you how it’s done!
How to Make Grilled Te…
Source https://tinybuddha.com/blog/need-less-have-more-life-expands-when-we-eliminate-excess/
“Knowledge is learning something new every day. Wisdom is letting go of something every day” ~Zen Saying
Simplicity, at its heart, comes down to eliminating the excess in our lives.
Excess needs, wants, possessions. The list goes on.
Society tries to sell us on the idea that having more in our lives should be the goal and is the answer. But is more really improving the quality of our lives?
Do more possessions beyond a certain point really add value to our lives?
Do more commitments in our diaries really help us feel less stressed and rushed?
Does always wanting the latest gadget…
Source https://tinybuddha.com/blog/need-less-have-more-life-expands-when-we-eliminate-excess/
“Knowledge is learning something new every day. Wisdom is letting go of something every day” ~Zen Saying
Simplicity, at its heart, comes down to eliminating the excess in our lives.
Excess needs, wants, possessions. The list goes on.
Society tries to sell us on the idea that having more in our lives should be the goal and is the answer. But is more really improving the quality of our lives?
Do more possessions beyond a certain point really add value to our lives?
Do more commitments in our diaries really help us feel less stressed and rushed?
Does always wanting the latest gadget…
Source https://tinybuddha.com/blog/10-signs-youre-being-true-to-yourself/
“The most confused we ever get is when we try to convince our heads of something that we know in our hearts is a lie.” ~Karen Moning
It’s painful and stressful to feel like you’re living a lie. Like you’re hiding how you really feel, saying what you think other people want to hear, and doing things you don’t actually want to do—just because you think you’re supposed to.
But sometimes we don’t recognize we’re doing this. We just know we feel off, or something feels wrong, and we’re not sure how to change it.
It makes sense that a lot of us struggle with being true to ourselves.
From a young age, we’re taught to be good, fall in line, and avoid making any waves—to lower our voices, do as we’re told, and quit our cry…
Source https://tinybuddha.com/blog/10-signs-youre-being-true-to-yourself/
“The most confused we ever get is when we try to convince our heads of something that we know in our hearts is a lie.” ~Karen Moning
It’s painful and stressful to feel like you’re living a lie. Like you’re hiding how you really feel, saying what you think other people want to hear, and doing things you don’t actually want to do—just because you think you’re supposed to.
But sometimes we don’t recognize we’re doing this. We just know we feel off, or something feels wrong, and we’re not sure how to change it.
It makes sense that a lot of us struggle with being true to ourselves.
From a young age, we’re taught to be good, fall in line, and avoid making any waves—to lower our voices, do as we’re told, and quit our cry…
Source https://zenhabits.net/trustme/
At the core of a lot of our difficulties is a lack of trust — especially trust in ourselves.
Think about these common difficulties that most of us face:
- What to focus on: We don’t trust our hearts to choose what we’d like to work on right now.
- Indecision: We get stuck on indecision because we don’t trust ourselves to choose what we really want, and we don’t trust ourselves to land on our feet if things turn out differently than we’d hoped.
- Procrastination / resistance: We feel resistance to a difficult (scary) task and then avoid it, resulting in procrastination … because we don’t trust ourselves to be with the discomfort, or trust ourselves to handle whatever comes after doing the task (handle criticism, judgment, or any other potential consequences).
- Fear or stress in u…
Source https://zenhabits.net/trustme/
At the core of a lot of our difficulties is a lack of trust — especially trust in ourselves.
Think about these common difficulties that most of us face:
- What to focus on: We don’t trust our hearts to choose what we’d like to work on right now.
- Indecision: We get stuck on indecision because we don’t trust ourselves to choose what we really want, and we don’t trust ourselves to land on our feet if things turn out differently than we’d hoped.
- Procrastination / resistance: We feel resistance to a difficult (scary) task and then avoid it, resulting in procrastination … because we don’t trust ourselves to be with the discomfort, or trust ourselves to handle whatever comes after doing the task (handle criticism, judgment, or any other potential consequences).
- Fear or stress in u…
Source https://www.theminimalists.com/enter/
The Minimalists are joined by professional organizer Dr. Julia Raz to talk about preventing clutter from entering your home. This is a standalone highlight from The Minimalists Private Podcast.
If you’d like to help us take advantage of the YouTube algorithm, then please leave a “starter like” and “starter comment” on this video.
P.S. The Minimalists are also sharing bite-sized podcasts on TikTok.
Subscribe to The Minimalists via
email.
The post Don’t Let Clutter Enter Your Home appeared first on <a rel="nofollow" href="https://www.theminimal…
Source https://www.theminimalists.com/enter/
The Minimalists are joined by professional organizer Dr. Julia Raz to talk about preventing clutter from entering your home. This is a standalone highlight from The Minimalists Private Podcast.
If you’d like to help us take advantage of the YouTube algorithm, then please leave a “starter like” and “starter comment” on this video.
P.S. The Minimalists are also sharing bite-sized podcasts on TikTok.
Subscribe to The Minimalists via
email.
The post Don’t Let Clutter Enter Your Home appeared first on <a rel="nofollow" href="https://www.theminimal…
Source https://seniorplanet.org/socialize-y-rescate-animales/
Rescatar animales también puede rescatar a las personas, del aislamiento y la soledad. Los animales son un gran puente para conocer a otros.
The post Socialize… y rescate animales appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/socialize-y-rescate-animales/
Rescatar animales también puede rescatar a las personas, del aislamiento y la soledad. Los animales son un gran puente para conocer a otros.
The post Socialize… y rescate animales appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2022/08/are-pharmacological-approaches-to-slow-aging-in-fact-promising/
Today’s open access review paper looks over a selection of what I would consider to be largely unpromising small molecules, each with evidence for their ability to slow aging, but very modestly and unreliably in most cases. Looking at the bigger picture, for much of the public it is still surprising to hear that the pace of aging can be adjusted via any form of therapy, so there is probably a role for simple, low-cost small molecule drugs in the process of education that leads to more serious efforts aimed at producing the means of human rejuvenation. Still, entirely too much effort is devoted towards small molecules that have inconsistent animal data (such as metformin), and also small effect sizes (such as metformin), and further are probably outpaced by the benefits of exercise – metformin again, but near all of the panoply of other <a href="h…
Source https://www.fightaging.org/archives/2022/08/are-pharmacological-approaches-to-slow-aging-in-fact-promising/
Today’s open access review paper looks over a selection of what I would consider to be largely unpromising small molecules, each with evidence for their ability to slow aging, but very modestly and unreliably in most cases. Looking at the bigger picture, for much of the public it is still surprising to hear that the pace of aging can be adjusted via any form of therapy, so there is probably a role for simple, low-cost small molecule drugs in the process of education that leads to more serious efforts aimed at producing the means of human rejuvenation. Still, entirely too much effort is devoted towards small molecules that have inconsistent animal data (such as metformin), and also small effect sizes (such as metformin), and further are probably outpaced by the benefits of exercise – metformin again, but near all of the panoply of other <a href="h…
