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7 things you can stop worrying about

Source https://www.nerdfitness.com/blog/7-things-you-can-stop-worrying-about/

Fitness shouldn’t be one more thing to feel bad about.

So today, I want to take a few worries off of your plate.

Think of this as a permission slip to stop overthinking the stuff that doesn’t matter nearly as much as you’ve been told.

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Source https://www.nerdfitness.com/blog/7-things-you-can-stop-worrying-about/

Fitness shouldn’t be one more thing to feel bad about.

So today, I want to take a few worries off of your plate.

Think of this as a permission slip to stop overthinking the stuff that doesn’t matter nearly as much as you’ve been told.

<h2 class="" data-s…

Manufacturing Cell Vesicles for Therapy via Membrane Extrusion

Source https://www.fightaging.org/archives/2025/11/manufacturing-cell-vesicles-for-therapy-via-membrane-extrusion/

Therapeutic use of extracellular vesicles seems likely to replace much of the present use of stem cell therapy, as these first generation stem cell transplantation therapies achieve benefits near entirely via the signaling generated by the transplanted cells in the short period of time in which they survive. Much of that signaling takes the form of extracellular vesicles, membrane-wrapped packages of molecules. Vesicles can be harvested from cell cultures, and are much easier to store and transport than is the case for cells, allowing centralization of the harder part of the manufacturing process that is managing stem cell cultures.

In recent years researchers have moved on from simply harvesting vesicles to finding ways to induce cells to create a lot more vesicles than is …

Source https://www.fightaging.org/archives/2025/11/manufacturing-cell-vesicles-for-therapy-via-membrane-extrusion/

Therapeutic use of extracellular vesicles seems likely to replace much of the present use of stem cell therapy, as these first generation stem cell transplantation therapies achieve benefits near entirely via the signaling generated by the transplanted cells in the short period of time in which they survive. Much of that signaling takes the form of extracellular vesicles, membrane-wrapped packages of molecules. Vesicles can be harvested from cell cultures, and are much easier to store and transport than is the case for cells, allowing centralization of the harder part of the manufacturing process that is managing stem cell cultures.

In recent years researchers have moved on from simply harvesting vesicles to finding ways to induce cells to create a lot more vesicles than is …

Why Narcissistic Abuse Doesn’t Define You and How I Found the Love I Deserve

Source https://tinybuddha.com/blog/why-narcissistic-abuse-doesnt-define-you-and-how-i-found-the-love-i-deserve/

“When it hurts to move on, just remember the pain you felt hanging on.” ~Unknown

There was a time when I thought my heart would never heal.

I’d been lied to, betrayed, and broken by a man I thought I loved. A man who turned out to be nothing more than a beautifully packaged nightmare.

If you’ve ever been hurt by a narcissist, you know that the pain cuts deeper than most people can imagine. You know the way it seeps into your bones, the way it makes you question your worth and replay every moment, wondering if you could have stopped it.

I’ll never forget that night in Paris when I learned what love is not.

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Source https://tinybuddha.com/blog/why-narcissistic-abuse-doesnt-define-you-and-how-i-found-the-love-i-deserve/

“When it hurts to move on, just remember the pain you felt hanging on.” ~Unknown

There was a time when I thought my heart would never heal.

I’d been lied to, betrayed, and broken by a man I thought I loved. A man who turned out to be nothing more than a beautifully packaged nightmare.

If you’ve ever been hurt by a narcissist, you know that the pain cuts deeper than most people can imagine. You know the way it seeps into your bones, the way it makes you question your worth and replay every moment, wondering if you could have stopped it.

I’ll never forget that night in Paris when I learned what love is not.

<p style="font-w…

Thanksgiving Turkey Meatballs

Source https://minimalistbaker.com/thanksgiving-turkey-meatballs/

Thanksgiving Turkey Meatballs

If all the classic, herby, savory flavors of Thanksgiving came together into one satisfying main dish, these turkey meatballs would be it! They’re WAY easier to master than baking a turkey, making them perfect for small holiday gatherings and year-round Thanksgiving cravings.

Just 10 ingredients required and perfect for pairing with Thanksgiving classics like mashed potatoes, green bean casserole, and cranberry sauce. Let us show you how it’s done!

Ingredients for Thanksgiving Turkey Meatballs

These EASY, savory ground turkey meatballs require just a few basic ingredients:

  • Ground turkey</stron…

Source https://minimalistbaker.com/thanksgiving-turkey-meatballs/

Thanksgiving Turkey Meatballs

If all the classic, herby, savory flavors of Thanksgiving came together into one satisfying main dish, these turkey meatballs would be it! They’re WAY easier to master than baking a turkey, making them perfect for small holiday gatherings and year-round Thanksgiving cravings.

Just 10 ingredients required and perfect for pairing with Thanksgiving classics like mashed potatoes, green bean casserole, and cranberry sauce. Let us show you how it’s done!

Ingredients for Thanksgiving Turkey Meatballs

These EASY, savory ground turkey meatballs require just a few basic ingredients:

  • Ground turkey</stron…

Modifying the Behavior of Gut Microbes to Generate Colanic Acid Modestly Slows Aging in Nematode Worms

Source https://www.fightaging.org/archives/2025/11/modifying-the-behavior-of-gut-microbes-to-generate-colanic-acid-modestly-slows-aging-in-nematode-worms/

Much of the focus on the gut microbiome in aging revolves around its composition, the relative size of various populations of different microbial species, and how that composition changes over time. There is another dimension to consider, however, which is the activity and behavior of specific microbial species and how that is affected by the environment they find themselves in. This second dimension is relatively underexplored at the present time. As researchers here note, there may well be opportunities to improve health by adjusting the behavior of gut microbes in deterministic ways, rather than by changing the size of their populations.

Microbiota-derived metabolites have emerged as key regulators of longevity. The metabolic …

Source https://www.fightaging.org/archives/2025/11/modifying-the-behavior-of-gut-microbes-to-generate-colanic-acid-modestly-slows-aging-in-nematode-worms/

Much of the focus on the gut microbiome in aging revolves around its composition, the relative size of various populations of different microbial species, and how that composition changes over time. There is another dimension to consider, however, which is the activity and behavior of specific microbial species and how that is affected by the environment they find themselves in. This second dimension is relatively underexplored at the present time. As researchers here note, there may well be opportunities to improve health by adjusting the behavior of gut microbes in deterministic ways, rather than by changing the size of their populations.

Microbiota-derived metabolites have emerged as key regulators of longevity. The metabolic …

Greater Inflammasome Induced IL-1β in Male Periodontitis May Drive Worse Pathology

Source https://www.fightaging.org/archives/2025/11/greater-inflammasome-induced-il-1%CE%B2-in-male-periodontitis-may-drive-worse-pathology/

Why does the inflammatory gum disease periodontitis tend to be worse in men versus women? As a possible answer to that question, researchers here demonstrate a sex difference in mammals in the inflammatory processes that drive the pathology of periodontitis. The condition progresses from chronic inflammation to bone loss and tooth loss, one example amongst many of the way in which unresolved inflammatory signaling changes the behavior of cells for the worse to cause disruption to tissue structure and function.

The inflammasome initiates inflammation via the maturation of interleukin-1 beta (IL-1β). Periodontitis is a prevalent, male-biased disease characterized by inflammation-driven bone loss, yet the mechanisms of this…

Source https://www.fightaging.org/archives/2025/11/greater-inflammasome-induced-il-1%CE%B2-in-male-periodontitis-may-drive-worse-pathology/

Why does the inflammatory gum disease periodontitis tend to be worse in men versus women? As a possible answer to that question, researchers here demonstrate a sex difference in mammals in the inflammatory processes that drive the pathology of periodontitis. The condition progresses from chronic inflammation to bone loss and tooth loss, one example amongst many of the way in which unresolved inflammatory signaling changes the behavior of cells for the worse to cause disruption to tissue structure and function.

The inflammasome initiates inflammation via the maturation of interleukin-1 beta (IL-1β). Periodontitis is a prevalent, male-biased disease characterized by inflammation-driven bone loss, yet the mechanisms of this…

“¡Papá, AYUDA!” – Preocupante nueva estafa dirigida a personas mayores

Source https://seniorplanet.org/articles-es-nueva-estafa-personas-mayores/

Dentro de un secuestro virtual: un jubilado de 65 años respondió una llamada de un número desconocido y escuchó un grito: “¡Papá, necesito tu ayuda!”

The post <em>“¡Papá, AYUDA!”</em> – Preocupante nueva estafa dirigida a personas mayores appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-es-nueva-estafa-personas-mayores/

Dentro de un secuestro virtual: un jubilado de 65 años respondió una llamada de un número desconocido y escuchó un grito: “¡Papá, necesito tu ayuda!”

The post <em>“¡Papá, AYUDA!”</em> – Preocupante nueva estafa dirigida a personas mayores appeared first on Senior Planet from AARP.

Pregúntele al Techspert: Nuevas funciones de Accesibilidad en iOS 26

Source https://seniorplanet.org/articles-es-nuevas-funciones-de-accesibilidad-en-ios-26/

Aprenda más sobre las poderosas nuevas funciones de accesibilidad del iOS 26 que hacen que el iPhone sea más fácil de ver, escuchar y controlar, para todos.

The post Pregúntele al Techspert: Nuevas funciones de Accesibilidad en iOS 26 appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-es-nuevas-funciones-de-accesibilidad-en-ios-26/

Aprenda más sobre las poderosas nuevas funciones de accesibilidad del iOS 26 que hacen que el iPhone sea más fácil de ver, escuchar y controlar, para todos.

The post Pregúntele al Techspert: Nuevas funciones de Accesibilidad en iOS 26 appeared first on Senior Planet from AARP.

Mechanisms Likely Relevant to Sirtuin 6 Effects on Longevity

Source https://www.fightaging.org/archives/2025/11/mechanisms-likely-relevant-to-sirtuin-6-effects-on-longevity/

Sirtuins are a family of proteins that largely undertake specific modification of other proteins, removing certain decorations that have been attached to those proteins. A great deal of the exceedingly complex regulation of cellular metabolism involves changing the function of molecules by adding or removing decorations such as acetyl groups, methyl groups, and so forth. Several sirtuins have been investigated in the context of aging, showing some ability to alter the operation of cellular metabolism to modestly slow aspects of aging in animal models. <a href="https://www.fightaging.org/archives/2017/12…

Source https://www.fightaging.org/archives/2025/11/mechanisms-likely-relevant-to-sirtuin-6-effects-on-longevity/

Sirtuins are a family of proteins that largely undertake specific modification of other proteins, removing certain decorations that have been attached to those proteins. A great deal of the exceedingly complex regulation of cellular metabolism involves changing the function of molecules by adding or removing decorations such as acetyl groups, methyl groups, and so forth. Several sirtuins have been investigated in the context of aging, showing some ability to alter the operation of cellular metabolism to modestly slow aspects of aging in animal models. <a href="https://www.fightaging.org/archives/2017/12…

The Onset of Hypertension Causes Detrimental Changes in Cell Behavior Before Blood Pressure Increases

Source https://www.fightaging.org/archives/2025/11/the-onset-of-hypertension-causes-detrimental-changes-in-cell-behavior-before-blood-pressure-increases/

Hypertension is the name given to a state of high blood pressure. The onset of this condition typically progresses over time, as aging or lifestyle choices cause slowly increasing dysfunction in the systems of regulation and feedback that control blood pressure. A number of mechanisms are involved in determination of blood pressure, such as the kidney’s regulation of the volume of fluid in blood, the ability of blood vessels to contract and dilate to change the overall volume of the vascular system, and the pace at which the heart beats. The important processes of regulation are known as the renin-angiotensin-aldosterone system, in which signals pass back and forth from kidney to vasculature and other involved organs, including l…

Source https://www.fightaging.org/archives/2025/11/the-onset-of-hypertension-causes-detrimental-changes-in-cell-behavior-before-blood-pressure-increases/

Hypertension is the name given to a state of high blood pressure. The onset of this condition typically progresses over time, as aging or lifestyle choices cause slowly increasing dysfunction in the systems of regulation and feedback that control blood pressure. A number of mechanisms are involved in determination of blood pressure, such as the kidney’s regulation of the volume of fluid in blood, the ability of blood vessels to contract and dilate to change the overall volume of the vascular system, and the pace at which the heart beats. The important processes of regulation are known as the renin-angiotensin-aldosterone system, in which signals pass back and forth from kidney to vasculature and other involved organs, including l…

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