Source https://www.fightaging.org/archives/2021/12/the-possibility-of-senolytic-vaccinations-to-control-the-burden-of-senescent-cells/
Arguably the primary reason why the number of senescent cells increases with age throughout the body is the growing failure of the immune system to clear these errant cells. The reasons for that failure are not well understood in detail, though some inroads have been made into that area of research. Both the innate and adaptive immune system are involved in clearance of senescent cells, so in principle there should be a plethora of mechanisms that could be tar…
Source https://www.fightaging.org/archives/2021/12/the-possibility-of-senolytic-vaccinations-to-control-the-burden-of-senescent-cells/
Arguably the primary reason why the number of senescent cells increases with age throughout the body is the growing failure of the immune system to clear these errant cells. The reasons for that failure are not well understood in detail, though some inroads have been made into that area of research. Both the innate and adaptive immune system are involved in clearance of senescent cells, so in principle there should be a plethora of mechanisms that could be tar…
Source https://greatist.com/health/niacinamide
As a skin care ingredient, niacinamide is gaining popularity super fast because of a long list of reported benefits. You may even already have some products in your skin care arsenal that contain it and not even know it.
So here’s the scoop on exactly what it is, what it can do for your skin, and a few ways to add it to your daily routine, along with some of our top picks for niacinamide supplements and skin care products.
A quick look at niacinamide and its benefits
In a hurry and need to know what niacinamide is all about like, RN? Here’s the tl;dr version:
- Niacinamide (aka vitamin B3) is the active form of niacin, a vitamin your body needs to produce energy.
- It has some antioxidant and anti-inflammatory effects, which means it has TONS of skin benefits when taken orally OR applied …
Source https://greatist.com/health/niacinamide
As a skin care ingredient, niacinamide is gaining popularity super fast because of a long list of reported benefits. You may even already have some products in your skin care arsenal that contain it and not even know it.
So here’s the scoop on exactly what it is, what it can do for your skin, and a few ways to add it to your daily routine, along with some of our top picks for niacinamide supplements and skin care products.
A quick look at niacinamide and its benefits
In a hurry and need to know what niacinamide is all about like, RN? Here’s the tl;dr version:
- Niacinamide (aka vitamin B3) is the active form of niacin, a vitamin your body needs to produce energy.
- It has some antioxidant and anti-inflammatory effects, which means it has TONS of skin benefits when taken orally OR applied …
Source https://tinybuddha.com/blog/how-small-daily-challenges-can-actually-be-gifts-in-disguise/
“Smile at your patterns.” ~Tsoknyi Rinpoche
Partway through Eckhart Tolle’s Conscious Manifestation course, I furiously jotted down his teachings about challenges and obstacles to remind myself that they’re not only a normal part of the human experience but necessary for spiritual growth. “Yes!!!!” I wrote in agreement.
When faced with difficulty, the human tendency is to react, resist, and resent, and when we do this, we add suffering to an already difficult situation. This tendency is reflexive within me, and my mindfulness practice has enabled me to either observe the cascading habit pattern as it unfolds, which disentangles me from its snare, or, to gently accept what is happening and proceed with calm action and a quiet mind.
Wh…
Source https://tinybuddha.com/blog/how-small-daily-challenges-can-actually-be-gifts-in-disguise/
“Smile at your patterns.” ~Tsoknyi Rinpoche
Partway through Eckhart Tolle’s Conscious Manifestation course, I furiously jotted down his teachings about challenges and obstacles to remind myself that they’re not only a normal part of the human experience but necessary for spiritual growth. “Yes!!!!” I wrote in agreement.
When faced with difficulty, the human tendency is to react, resist, and resent, and when we do this, we add suffering to an already difficult situation. This tendency is reflexive within me, and my mindfulness practice has enabled me to either observe the cascading habit pattern as it unfolds, which disentangles me from its snare, or, to gently accept what is happening and proceed with calm action and a quiet mind.
Wh…
Source https://www.fightaging.org/archives/2021/12/angptl2-as-a-marker-of-cellular-senescence/
The accumulation of senescent cells is an important contributing cause of degenerative aging. Since these cells can be specifically targeted via a range of mechanisms, and selective destruction of senescent cells produces significant and rapid rejuvenation in animal studies, there is considerable interest in the research community in finding novel ways to measure the burden of cellular senescence. Senescent cells secrete a mix of pro-growth, inflammatory molecules into circulation, and so it is possible that some of those m…
Source https://www.fightaging.org/archives/2021/12/angptl2-as-a-marker-of-cellular-senescence/
The accumulation of senescent cells is an important contributing cause of degenerative aging. Since these cells can be specifically targeted via a range of mechanisms, and selective destruction of senescent cells produces significant and rapid rejuvenation in animal studies, there is considerable interest in the research community in finding novel ways to measure the burden of cellular senescence. Senescent cells secrete a mix of pro-growth, inflammatory molecules into circulation, and so it is possible that some of those m…
Source https://www.fightaging.org/archives/2021/12/supporting-evidence-for-senolytics-to-be-an-effective-treatment-for-alzheimers-disease/
Neurodegenerative diseases are strongly associated with the buildup of protein aggregates, misfolded or altered amyloid-β, tau, α-synuclein, and so forth, wherein one altered molecule can encourage others to also alter, leading to solid deposits in brain tissue and a surrounding halo of toxic biochemistry that degrades cell function and kills cells. Much of the Alzheimer’s research and development to date has focused on how to clear those aggregates; unfortunately success in clearance of amyloid-β in Alzheimer’s disease has <a href="https://www.fightaging.org/archives/…
Source https://www.fightaging.org/archives/2021/12/supporting-evidence-for-senolytics-to-be-an-effective-treatment-for-alzheimers-disease/
Neurodegenerative diseases are strongly associated with the buildup of protein aggregates, misfolded or altered amyloid-β, tau, α-synuclein, and so forth, wherein one altered molecule can encourage others to also alter, leading to solid deposits in brain tissue and a surrounding halo of toxic biochemistry that degrades cell function and kills cells. Much of the Alzheimer’s research and development to date has focused on how to clear those aggregates; unfortunately success in clearance of amyloid-β in Alzheimer’s disease has <a href="https://www.fightaging.org/archives/…
Source https://www.theminimalists.com/p318/
By Joshua Fields Millburn & Ryan Nicodemus · Follow: Facebook, Twitter, Instagram
In this episode of The Minimalists Podcast, Joshua and Ryan talk about what they’ve learned, how they’ve grown, and in what ways they’ve subtracted since they…
Source https://www.theminimalists.com/p318/
By Joshua Fields Millburn & Ryan Nicodemus · Follow: Facebook, Twitter, Instagram
In this episode of The Minimalists Podcast, Joshua and Ryan talk about what they’ve learned, how they’ve grown, and in what ways they’ve subtracted since they…
Source https://greatist.com/discover/adjustable-mattresses
Picking a new mattress is kind of like picking a life partner. It can be hard to commit. What if you opt for something that’s super firm and then realize your body prefers marshmallow softness? Or what if your pup doesn’t love it too?
If you’re scared of sealing the deal on the wrong setup, consider an adjustable mattress. These bad boys can go from soft to supportive in an instant — you just have to adjust the inflation.
Not sure where to find the bed of your dreams? We’ve rounded up the best adjustable mattresses just for you.
Source https://greatist.com/discover/adjustable-mattresses
Picking a new mattress is kind of like picking a life partner. It can be hard to commit. What if you opt for something that’s super firm and then realize your body prefers marshmallow softness? Or what if your pup doesn’t love it too?
If you’re scared of sealing the deal on the wrong setup, consider an adjustable mattress. These bad boys can go from soft to supportive in an instant — you just have to adjust the inflation.
Not sure where to find the bed of your dreams? We’ve rounded up the best adjustable mattresses just for you.
Source https://www.ageinplacetech.com/blog/new-report-beyond-diy-future-smart-homes-and-older-adults
Within five years, predictive, proactive and adaptive smart home solutions that support health and wellbeing, comfort and safety, and engagement and entertainment will emerge to meet the needs of older adults, including subscription-based services that are integrated with wearables. Remote configuration and updates will be standard, and health insurers will be interested in smart home technology as a deterrent to hospitalization. With the addition of predictive analytics and machine learning, the home can become a participating caregiver for the oldest and frailest. What are a few of the trends that will make that feasible?
Source https://www.ageinplacetech.com/blog/new-report-beyond-diy-future-smart-homes-and-older-adults
Within five years, predictive, proactive and adaptive smart home solutions that support health and wellbeing, comfort and safety, and engagement and entertainment will emerge to meet the needs of older adults, including subscription-based services that are integrated with wearables. Remote configuration and updates will be standard, and health insurers will be interested in smart home technology as a deterrent to hospitalization. With the addition of predictive analytics and machine learning, the home can become a participating caregiver for the oldest and frailest. What are a few of the trends that will make that feasible?
Source https://zenhabits.net/slow-holidays/
For the past couple of Decembers, I’ve created a lot of spaciousness and slowness for myself. It’s a beautiful way to wind down the year and reflect on my life.
The holiday season can be a rushed affair for many people, but it doesn’t have to be. I’d like to share a few ideas in slowing things down for the holidays.
If you’d like to create a slow holiday season for yourself, it’s doable, with intention.
Here are some ideas:
- Create space. Our days tend to be filled automatically, whether it’s with work tasks, emails and messages, social media, calls and meetings, or just random Internet stuff. If we want space, we have to create it intentionally — block off a full day or weekend for time away from devices, have a work stop time in the late afternoon or early evening, create blocks of time for rest or walks, have inten…
Source https://zenhabits.net/slow-holidays/
For the past couple of Decembers, I’ve created a lot of spaciousness and slowness for myself. It’s a beautiful way to wind down the year and reflect on my life.
The holiday season can be a rushed affair for many people, but it doesn’t have to be. I’d like to share a few ideas in slowing things down for the holidays.
If you’d like to create a slow holiday season for yourself, it’s doable, with intention.
Here are some ideas:
- Create space. Our days tend to be filled automatically, whether it’s with work tasks, emails and messages, social media, calls and meetings, or just random Internet stuff. If we want space, we have to create it intentionally — block off a full day or weekend for time away from devices, have a work stop time in the late afternoon or early evening, create blocks of time for rest or walks, have inten…
Source https://minimalistbaker.com/easy-almond-brittle-4-ingredients/
The idea for this brittle came to me one night when I was about to drift off to sleep (as many ideas do). I dreamt of a brittled almond cookie with serious crunch, so we started there. But after a few failed attempts we stopped trying to separate them into clumps and just made almond brittle on a baking sheet, and it was the best, happiest semi-accidental decision ever!
What’s it like? This is like grown-up peanut brittle but with wholesome almonds, natural sweeteners, and no butter in sight.
<a href="https://minimalistbaker.com/easy-almon…
Source https://minimalistbaker.com/easy-almond-brittle-4-ingredients/
The idea for this brittle came to me one night when I was about to drift off to sleep (as many ideas do). I dreamt of a brittled almond cookie with serious crunch, so we started there. But after a few failed attempts we stopped trying to separate them into clumps and just made almond brittle on a baking sheet, and it was the best, happiest semi-accidental decision ever!
What’s it like? This is like grown-up peanut brittle but with wholesome almonds, natural sweeteners, and no butter in sight.
<a href="https://minimalistbaker.com/easy-almon…
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