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What I See Clearly Now That I Can’t See Clearly

Source https://tinybuddha.com/blog/what-i-see-clearly-now-that-i-cant-see-clearly/

“The most beautiful things in the world cannot be seen… they must be felt with the heart.” ~Helen Keller

I didn’t want to admit it—not to myself, not to anyone. But I am slowly going blind.

That truth is difficult to write, harder still to live. I’m seventy years old. I’ve survived war zones, illness, caregiving, and creative risks. I’ve worked as a documentary filmmaker, teacher, and mentor. But this—this quiet, gradual vanishing of sight—feels like the loneliest struggle of all.

I have moderate to advanced macular degeneration in both eyes. My right eye is nearly gone, and my left is fading. Every…

Source https://tinybuddha.com/blog/what-i-see-clearly-now-that-i-cant-see-clearly/

“The most beautiful things in the world cannot be seen… they must be felt with the heart.” ~Helen Keller

I didn’t want to admit it—not to myself, not to anyone. But I am slowly going blind.

That truth is difficult to write, harder still to live. I’m seventy years old. I’ve survived war zones, illness, caregiving, and creative risks. I’ve worked as a documentary filmmaker, teacher, and mentor. But this—this quiet, gradual vanishing of sight—feels like the loneliest struggle of all.

I have moderate to advanced macular degeneration in both eyes. My right eye is nearly gone, and my left is fading. Every…

This Technique Eliminates Visible Mess

Source https://www.theminimalists.com/tote/

The Minimalists talk about the One, Tote One Day decluttering method.

What’s your favorite decluttering method? Let us know in the YouTube comments.

The post This Technique Eliminates Visible Mess appeared first on The Minimalists.

Source https://www.theminimalists.com/tote/

The Minimalists talk about the One, Tote One Day decluttering method.

What’s your favorite decluttering method? Let us know in the YouTube comments.

The post This Technique Eliminates Visible Mess appeared first on The Minimalists.

Age-Related Sarcopenia Correlates with Cardiovascular and Respiratory Disease

Source https://www.fightaging.org/archives/2025/11/age-related-sarcopenia-correlates-with-cardiovascular-and-respiratory-disease/

Muscle mass and strength decline with age, a long-term consequence of accumulating molecular damage and its effects on muscle stem cell populations and neuromuscular junctions, among other mechanisms. Once past an arbitrary line in the sand, this loss is defined as an age-related disease and called sarcopenia, a part of age-related frailty. Here, researchers show that the state of sarcopenia correlates with the presence of age-related cardiovascular and respiratory conditions. This is not surprising: all of these conditions arise from the same underly…

Source https://www.fightaging.org/archives/2025/11/age-related-sarcopenia-correlates-with-cardiovascular-and-respiratory-disease/

Muscle mass and strength decline with age, a long-term consequence of accumulating molecular damage and its effects on muscle stem cell populations and neuromuscular junctions, among other mechanisms. Once past an arbitrary line in the sand, this loss is defined as an age-related disease and called sarcopenia, a part of age-related frailty. Here, researchers show that the state of sarcopenia correlates with the presence of age-related cardiovascular and respiratory conditions. This is not surprising: all of these conditions arise from the same underly…

Mitochondrially Targeted Fluoropolymer Nanoparticle Induces Mitophagy to Improve Function

Source https://www.fightaging.org/archives/2025/11/mitochondrially-targeted-fluoropolymer-nanoparticle-induces-mitophagy-to-improve-function/

Finding molecules or nanoparticles that selectively target mitochondria and induce improved function is the most developed of the various strategies that might be employed to at least partially reverse the age-related loss of mitochondrial capacity thought to be important in age-related disease and dysfunction. Most of the small molecules developed to date appear to work by improving mitophagy, the processes of quality control that recycle worn and dysfunctional mitochondria, but the precise details of the mechanisms involved are incompletely understood. Mitophagy itself is incompletely understood. Continuing this trend, researchers here present a nanopar…

Source https://www.fightaging.org/archives/2025/11/mitochondrially-targeted-fluoropolymer-nanoparticle-induces-mitophagy-to-improve-function/

Finding molecules or nanoparticles that selectively target mitochondria and induce improved function is the most developed of the various strategies that might be employed to at least partially reverse the age-related loss of mitochondrial capacity thought to be important in age-related disease and dysfunction. Most of the small molecules developed to date appear to work by improving mitophagy, the processes of quality control that recycle worn and dysfunctional mitochondria, but the precise details of the mechanisms involved are incompletely understood. Mitophagy itself is incompletely understood. Continuing this trend, researchers here present a nanopar…

The 2026 Tiny Buddha Calendar Is Ready for Holiday Gifting!

Source https://tinybuddha.com/blog/the-2026-tiny-buddha-calendar-is-ready-for-holiday-gifting/

Tiny Buddha's 2026 Day-to-Day Calendar

Hi friend! As we head into the holiday season, I know many of us are starting to think about gifts for the people we love (and maybe a few things for ourselves as well). With that in mind, I wanted to remind you that the 2026 Tiny Buddha Day-to-Day Calendar is now available.

It’s one of my favorite projects every year because I include the kind of daily reminders that I personally find validating, comforting, and encouraging—some from me, some from site contributors, and some from authors I enjoy. And as the number-one bestselling calendar in Mind-Body-Spirit for the past two years, I know it’s become an annual staple for lots of readers.

Featuring vibrant tear-off…

Source https://tinybuddha.com/blog/the-2026-tiny-buddha-calendar-is-ready-for-holiday-gifting/

Tiny Buddha's 2026 Day-to-Day Calendar

Hi friend! As we head into the holiday season, I know many of us are starting to think about gifts for the people we love (and maybe a few things for ourselves as well). With that in mind, I wanted to remind you that the 2026 Tiny Buddha Day-to-Day Calendar is now available.

It’s one of my favorite projects every year because I include the kind of daily reminders that I personally find validating, comforting, and encouraging—some from me, some from site contributors, and some from authors I enjoy. And as the number-one bestselling calendar in Mind-Body-Spirit for the past two years, I know it’s become an annual staple for lots of readers.

Featuring vibrant tear-off…

Podcast Ep. 514 | Guilty Pleasures

Source https://www.theminimalists.com/p514/

The Minimalists are reassessing guilty pleasures, reducing triggers that cause unnecessary pain, exploring annoying gifts, and much more.

Listen to the Episode

Apple · Spotify · Patreon

Discussed in This Episode

  • How do I let go of guilt after I buy something that doesn’t align with my values?
  • What’s one thing you feel guilty about having purchased?
  • Right Here, Right Now: …

Source https://www.theminimalists.com/p514/

The Minimalists are reassessing guilty pleasures, reducing triggers that cause unnecessary pain, exploring annoying gifts, and much more.

Listen to the Episode

Apple · Spotify · Patreon

Discussed in This Episode

  • How do I let go of guilt after I buy something that doesn’t align with my values?
  • What’s one thing you feel guilty about having purchased?
  • Right Here, Right Now: …

Lasting Epigenetic Changes Results from DNA Double Strand Break Repair

Source https://www.fightaging.org/archives/2025/11/lasting-epigenetic-changes-results-from-dna-double-strand-break-repair/

Gene expression is the complex process of producing proteins from a specific gene sequence encoded in DNA. The DNA in the nucleus of a cell is constantly surrounded by the machinery of gene expression. That machinery will attempt to start the process of transcription, the first step of gene expression, for any sequence it bumps into. Recall that every part of a cell is a chemical soup of molecules moving at incredible speeds, interacting with everything that they can possibly interact with, as fast as possible, countless times every second. Control over which genes are expressed at any given time is a matter of the structure of DNA, which sequences are exposed and which are spooled aroun…

Source https://www.fightaging.org/archives/2025/11/lasting-epigenetic-changes-results-from-dna-double-strand-break-repair/

Gene expression is the complex process of producing proteins from a specific gene sequence encoded in DNA. The DNA in the nucleus of a cell is constantly surrounded by the machinery of gene expression. That machinery will attempt to start the process of transcription, the first step of gene expression, for any sequence it bumps into. Recall that every part of a cell is a chemical soup of molecules moving at incredible speeds, interacting with everything that they can possibly interact with, as fast as possible, countless times every second. Control over which genes are expressed at any given time is a matter of the structure of DNA, which sequences are exposed and which are spooled aroun…

Ask Joan: Torn, Lost, Confused – and Scammed?

Source https://seniorplanet.org/articles-ask-joan-lost-confused/

Romance scam–or true love?  A reader reaches out to Joan about a long-distance relationship.

The post Ask Joan: Torn, Lost, Confused – and Scammed? appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-ask-joan-lost-confused/

Romance scam–or true love?  A reader reaches out to Joan about a long-distance relationship.

The post Ask Joan: Torn, Lost, Confused – and Scammed? appeared first on Senior Planet from AARP.

Half-Empty

Source https://www.theminimalists.com/half-empty/

By T.K. Coleman

A boy comes home from his first philosophy class.
He asks his mom: Is the glass half empty or half full?
She smiles. It depends. Are you drinking, or are you pouring?

<span style…

Source https://www.theminimalists.com/half-empty/

By T.K. Coleman

A boy comes home from his first philosophy class.
He asks his mom: Is the glass half empty or half full?
She smiles. It depends. Are you drinking, or are you pouring?

<span style…

Fight Aging! Newsletter, November 17th 2025

Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-17th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

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Source https://www.fightaging.org/archives/2025/11/fight-aging-newsletter-november-17th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

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