Category: Health and Fitness

Source https://www.theminimalists.com/toomuch/

T.K. Coleman talks about how to determine whether your stuff is clutter.

Do you have too much stuff? Let us know in the YouTube comments.

The post Do You Have Too Much Stuff? appeared first on The Minimalists.

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Source https://www.fightaging.org/archives/2025/10/nanoparticles-for-cancer-vaccines-designed-to-promote-a-greater-immune-response/

Researchers here explain that one of the challenges involved in the development of cancer vaccines lies in finding ways to provoke a sufficiently robust response from the immune system. The larger the number of distinct sensing mechanisms that can be triggered by a vaccine, the more roused the immune system becomes. But cancer vaccines tend to be based on a single antigen that identifies a distinctive cancer cell surface feature and single immune-provoking molecule that works via only one of the many possible immune activation pathways. Thus researchers here build and test a nanoparticle platform that allows for the assembly and delivery of a mix of molecules that interact with multiple immune-provoking pathways, intended to induce the immune system into a gr…

Source https://www.fightaging.org/archives/2025/10/a-discussion-of-cellular-senescence-in-tumor-associated-macrophages/

A tumor is a battleground of cell behavior and cell signaling. All cells can influence the behavior of surrounding cells via the signals they produce, and the evolution of cancerous cells that exhibit unfettered replication and continual mutation might be thought of as a blind search for whatever will trigger surrounding cells into assisting with more rapid growth. One of the most effective outcomes for tumor cells is to produce signals that can suppress the anti-cancer activities of the immune system. This capability is near universal for solid tumors, as without the ability to co-opt immune cells the tumor would likely never have come into being in the first place.

The innate immune cells known as macrophages are important in normal tissu…

Source https://www.ageinplacetech.com/blog/have-we-achieved-spoken-internet-where-we-can-ask-anything-maybe-not

Source https://seniorplanet.org/articles-es-como-detener-las-perdidas-de-orina/

Hasta un 29% de las personas entre los 60 y 70 años (la mayoría de ellas mujeres) padece incontinencia urinaria de esfuerzo, pero existen maneras de controlarla.

The post Cómo detener las pérdidas de orina appeared first on Senior Planet from AARP.

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Source https://www.fightaging.org/archives/2025/10/first-xenotransplantation-of-a-genetically-engineered-pig-liver-into-a-human-volunteer/

It remains to be seen as to whether xenotransplantation of organs from genetically engineered pigs will be competitive in comparison to the tissue engineering of new organs. Even given the challenges faced to date, it seems likely that xenotransplanation will be a going concern before the manufacture of viable tissue engineered organs. Initial trials in patients volunteers have taken place for the heart and kidney. As the report here illustrates, the last mile of discovery in which pig organs are transplanted into the first volunteers is likely to require as much work and reveal as many unforeseen issues as was the case for the earlier stages of development, in which the need for genetic engineering of the donor pigs was discovered.

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Source https://www.fightaging.org/archives/2025/10/introducing-naked-mole-rat-cgas-into-mice-and-flies-to-improve-dna-repair-and-treat-aging/

Naked mole-rats live as much as nine times longer than similarly sized rodent species, suffer little age-related decline of function until very late life, and there are next to no examples of individuals in captivity suffering from cancer. Researchers have spent more than twenty years investigating the biochemistry of this species, in search of the reasons for their longevity and resistance to cancer. As for other areas of the study of the comparative biology of aging, the hope is that some of these findings could form the basis for therapies to treat cancer and slow aging in humans. Whether this is the case remains to be seen; researchers have only comparatively recently reached the point of identifying specific differences that might be relevant, and then <a href="https://www.fightaging.org/a…

Source https://tinybuddha.com/blog/finding-balance-through-the-full-spectrum-of-emotion/

“As a solid rock is not shaken by the wind, the wise are not shaken by praise or blame.” ~The Dhammapada, Verse 81

Some moments lift you like moonlight. Others break you like a wave. I’ve lived through both—and I’ve come to believe that the way we move through these emotional thresholds defines who we become.

By thresholds, I mean the turning points in our lives—experiences so vivid, painful, or awe-filled that they pull us out of our usual routines and bring us face to face with something real. Some come in silence, others with sound and light, but they all leave a mark. And they ask something of us.

The Night the Frogs Were Singing</str…