It is never too late to start
Source https://www.theminimalists.com/allergic/
The Minimalists discuss Joshua’s allergy to clutter.
What kind of clutter are you allergic to? Let us know in the YouTube comments.
The post Help Me with My Kitchen Table Clutter! appeared first on The Minimalists.
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Source https://www.theminimalists.com/allergic/
The Minimalists discuss Joshua’s allergy to clutter.
What kind of clutter are you allergic to? Let us know in the YouTube comments.
The post Help Me with My Kitchen Table Clutter! appeared first on The Minimalists.
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A number of studies have suggested that people who survive to extreme old age exhibit better immune function throughout later life in comparison to peers who died at earlier ages. This analysis is an example of the type, and the data shows a natural killer cell population that exhibits signs of greater efficiency and more youthful activity. How and why long-lived individuals exhibit better immune function is a separate question. Studies of genetic variation in very large human data sets suggest that genetics plays a much smaller role in late life survival than the consequences of lifestyle choices (such as physical fitness) and environment…
A number of studies have suggested that people who survive to extreme old age exhibit better immune function throughout later life in comparison to peers who died at earlier ages. This analysis is an example of the type, and the data shows a natural killer cell population that exhibits signs of greater efficiency and more youthful activity. How and why long-lived individuals exhibit better immune function is a separate question. Studies of genetic variation in very large human data sets suggest that genetics plays a much smaller role in late life survival than the consequences of lifestyle choices (such as physical fitness) and environment…
Source https://www.fightaging.org/archives/2025/10/urolithin-a-as-a-senomorphic-treatment/
Urolithin A is a metabolite produced by gut bacteria, widely used as a dietary supplement, and has attracted attention from the aging research community for its positive effects on mitochondrial function. Of the various approaches to improving mitochondrial function with compounds classed as supplements, urolithin A is arguably the one that researchers know the least about when it comes to how exactly it functions, but equally there is stiff competition here. Knowledge of the exact mechanisms involved in translating the known immediate biochemical interactions of various compounds to better functioning mitochondria is sketchy at best for <a href="https://www.fightaging.org/archives/2018/07/more-than-you-wanted-to-know-about-nad-in-metabolism-and-aging…
Source https://www.fightaging.org/archives/2025/10/urolithin-a-as-a-senomorphic-treatment/
Urolithin A is a metabolite produced by gut bacteria, widely used as a dietary supplement, and has attracted attention from the aging research community for its positive effects on mitochondrial function. Of the various approaches to improving mitochondrial function with compounds classed as supplements, urolithin A is arguably the one that researchers know the least about when it comes to how exactly it functions, but equally there is stiff competition here. Knowledge of the exact mechanisms involved in translating the known immediate biochemical interactions of various compounds to better functioning mitochondria is sketchy at best for <a href="https://www.fightaging.org/archives/2018/07/more-than-you-wanted-to-know-about-nad-in-metabolism-and-aging…
Source https://www.fightaging.org/archives/2025/10/targeting-sting-to-reduce-neuroinflammation/
Cells evolved to detect foreign DNA and respond with inflammatory signaling. Unfortunately aging brings with it the mislocalization of fragments of the cell’s own DNA that is then misidentified as foreign, triggering these same inflammatory pathways. This response, and a number of other responses to forms of damage inside the cell, converge on the regulatory protein STING. The activity of STING that leads to inflammation is thus an interesting target for the treatment of age-related conditions involving excessive chronic inflammation. As for near all of the present potential approaches to the chronic inflammation of aging, sabotaging STING will harm the normal <a…
Source https://www.fightaging.org/archives/2025/10/targeting-sting-to-reduce-neuroinflammation/
Cells evolved to detect foreign DNA and respond with inflammatory signaling. Unfortunately aging brings with it the mislocalization of fragments of the cell’s own DNA that is then misidentified as foreign, triggering these same inflammatory pathways. This response, and a number of other responses to forms of damage inside the cell, converge on the regulatory protein STING. The activity of STING that leads to inflammation is thus an interesting target for the treatment of age-related conditions involving excessive chronic inflammation. As for near all of the present potential approaches to the chronic inflammation of aging, sabotaging STING will harm the normal <a…
Amyloid-β is an anti-microbial peptide, a component of the innate immune system. In the brain it is best known for increasing with age, misfolding, and then aggregating into toxic deposits. The presence of these aggregrates is thought to be the initial cause of Alzheimer’s disease, eventually inducing the late stage mechanisms of neuroinflammation and tau aggregation that kill neurons and ultimately kill the patient. On its own, it seems likely that amyloid-β aggregation is capable of producing on…
Amyloid-β is an anti-microbial peptide, a component of the innate immune system. In the brain it is best known for increasing with age, misfolding, and then aggregating into toxic deposits. The presence of these aggregrates is thought to be the initial cause of Alzheimer’s disease, eventually inducing the late stage mechanisms of neuroinflammation and tau aggregation that kill neurons and ultimately kill the patient. On its own, it seems likely that amyloid-β aggregation is capable of producing on…
Source https://tinybuddha.com/blog/how-to-be-well-in-unwell-times/
If you wake up anxious these days, you’re not alone. Between the news cycle, global uncertainty, and the chaos of daily life, it can feel like the world is spinning faster than we can catch our breath.
I’ve been feeling more anxious than usual myself lately—partly because of everything happening in my own life, and partly because so much in the world feels beyond our control. And yet, even in times like these, it’s still possible to find a sense of calm—to create a small pocket of peace within yourself that isn’t so easily shaken by what’s happening outside.
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Source https://tinybuddha.com/blog/how-to-be-well-in-unwell-times/
If you wake up anxious these days, you’re not alone. Between the news cycle, global uncertainty, and the chaos of daily life, it can feel like the world is spinning faster than we can catch our breath.
I’ve been feeling more anxious than usual myself lately—partly because of everything happening in my own life, and partly because so much in the world feels beyond our control. And yet, even in times like these, it’s still possible to find a sense of calm—to create a small pocket of peace within yourself that isn’t so easily shaken by what’s happening outside.
<p data-start="267…
Source https://www.fightaging.org/archives/2025/10/targeting-senescent-cells-in-the-treatment-of-cancer/
It seems clear that it is a good idea to remove the excess senescent cells generated by a cancer therapy after the cancer is defeated, or at the very least permanently suppress the inflammatory signaling generated by those senescent cells. The added burden of cellular senescence carried by cancer survivors is likely a major contribution to a shorter life expectancy and raised risk of age-related disease. Whether it is a good idea to remove or alter the behavior of senescent cells during cancer therapy, while a cancer is still active, remains a debated topic. The answer may be different on a cancer by cancer basis. The presence of senescent cells can both harm and help the growth of cancerous cells, but which effects dominate in any given context may be hard to determine in advance, depending on the biochemistry …
Source https://www.fightaging.org/archives/2025/10/targeting-senescent-cells-in-the-treatment-of-cancer/
It seems clear that it is a good idea to remove the excess senescent cells generated by a cancer therapy after the cancer is defeated, or at the very least permanently suppress the inflammatory signaling generated by those senescent cells. The added burden of cellular senescence carried by cancer survivors is likely a major contribution to a shorter life expectancy and raised risk of age-related disease. Whether it is a good idea to remove or alter the behavior of senescent cells during cancer therapy, while a cancer is still active, remains a debated topic. The answer may be different on a cancer by cancer basis. The presence of senescent cells can both harm and help the growth of cancerous cells, but which effects dominate in any given context may be hard to determine in advance, depending on the biochemistry …
Source https://seniorplanet.org/articles-tech-hub-save-on-phones/
The Tech Hub helps Senior Planet readers learn what to look for, and how to save, when shopping for a phone (just in time for the holiday buying season!)
The post Tech Hub: Save Money on Last Year’s Phone Models appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/articles-tech-hub-save-on-phones/
The Tech Hub helps Senior Planet readers learn what to look for, and how to save, when shopping for a phone (just in time for the holiday buying season!)
The post Tech Hub: Save Money on Last Year’s Phone Models appeared first on Senior Planet from AARP.
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When a cell becomes senescent it ceases replication, expands in size, and secretes a mix of pro-growth, pro-inflammatory molecules known as the senescence-associated secretory phenotype (SASP). Cells become senescent throughout life, mostly upon reaching the Hayflick limit on replication. Forms of damage, particularly DNA damage that might lead to cancer, the signaling of other senescent cells, and a toxic environment can …
When a cell becomes senescent it ceases replication, expands in size, and secretes a mix of pro-growth, pro-inflammatory molecules known as the senescence-associated secretory phenotype (SASP). Cells become senescent throughout life, mostly upon reaching the Hayflick limit on replication. Forms of damage, particularly DNA damage that might lead to cancer, the signaling of other senescent cells, and a toxic environment can …
Source https://tinybuddha.com/blog/the-enormous-cost-of-being-the-one-who-holds-everything-together/
“For most of history, Anonymous was a woman.” ~Virginia Woolf
There’s a kind of work in our society that doesn’t come with a title or pay, and for a long time, I didn’t even notice I was doing it. I just lived inside it. It shaped my days, my stress, my identity.
These days, I see it more clearly. I can name it now. I don’t only live inside it, but I still return to it—especially as a parent, especially when things stretch thin. The difference is now, I pause. I reflect. I ask myself if I have to hold it all. Sometimes I still do. But not by default. Not blindly. Well, usually anyway.
I’m writing to make the invisible visible. To name what I rarely h…
Source https://tinybuddha.com/blog/the-enormous-cost-of-being-the-one-who-holds-everything-together/
“For most of history, Anonymous was a woman.” ~Virginia Woolf
There’s a kind of work in our society that doesn’t come with a title or pay, and for a long time, I didn’t even notice I was doing it. I just lived inside it. It shaped my days, my stress, my identity.
These days, I see it more clearly. I can name it now. I don’t only live inside it, but I still return to it—especially as a parent, especially when things stretch thin. The difference is now, I pause. I reflect. I ask myself if I have to hold it all. Sometimes I still do. But not by default. Not blindly. Well, usually anyway.
I’m writing to make the invisible visible. To name what I rarely h…