Category: Health and Fitness

Continued Progress Towards Reversible Vitrification of Organs

Source https://www.fightaging.org/archives/2025/10/continued-progress-towards-reversible-vitrification-of-organs/

Cryonics is important. Low-temperature storage of the brain is presently the only near-term approach that can provide those who die from old age with some greater than zero chance at a renewed life in the future. The cryonics industry has remained small since its inception decades ago, and only a few hundred people have been cryopreserved. The best way to expand and advance the small cryonics industry is to develop reversible vitrification of organs, a capability that has been demonstrated at the small scale in laboratories, and which ha…

Source https://www.fightaging.org/archives/2025/10/continued-progress-towards-reversible-vitrification-of-organs/

Cryonics is important. Low-temperature storage of the brain is presently the only near-term approach that can provide those who die from old age with some greater than zero chance at a renewed life in the future. The cryonics industry has remained small since its inception decades ago, and only a few hundred people have been cryopreserved. The best way to expand and advance the small cryonics industry is to develop reversible vitrification of organs, a capability that has been demonstrated at the small scale in laboratories, and which ha…

MT1-MMP Inhibition Restores Some Lost Cognitive Function in Both Aged Mice and Obese Mice

Source https://www.fightaging.org/archives/2025/10/mt1-mmp-inhibition-restores-some-lost-cognitive-function-in-both-aged-mice-and-obese-mice/

There is at present a tremendous appetite for the development of novel pharmacological approaches to weight loss. This is in large part a response to the rising prevalence of obesity. No robustly proven answer exists as to the question of why exactly people are now becoming obese in such large numbers. There is no shortage of hypotheses, from excessive use of modern sugar substitutes to lack of exercise to specific widespread dietary additives to the presence of microplastics in the environment to changes in the average gut microbiome composition. The absence of a good answer and means of prevention means that efforts have turned to pharmacology for weight loss. This is not a new phenomenon, weight loss drugs have been greeted with enthusiasm since use of the …

Source https://www.fightaging.org/archives/2025/10/mt1-mmp-inhibition-restores-some-lost-cognitive-function-in-both-aged-mice-and-obese-mice/

There is at present a tremendous appetite for the development of novel pharmacological approaches to weight loss. This is in large part a response to the rising prevalence of obesity. No robustly proven answer exists as to the question of why exactly people are now becoming obese in such large numbers. There is no shortage of hypotheses, from excessive use of modern sugar substitutes to lack of exercise to specific widespread dietary additives to the presence of microplastics in the environment to changes in the average gut microbiome composition. The absence of a good answer and means of prevention means that efforts have turned to pharmacology for weight loss. This is not a new phenomenon, weight loss drugs have been greeted with enthusiasm since use of the …

How to Brew a Balanced Plate 🧙‍♀️

Source https://www.nerdfitness.com/blog/brew-a-balanced-plate/

Halloween is just around the corner, and while I won’t be handing out any spell books, I will share a little witchcraft for building meals that actually work in real life. 🪄

One of my clients was struggling recently. Between long workdays and late nights caring for her sick pup, she didn’t have the time or brainpower to cook elaborate meals. She wanted something simple:

<img s…

Source https://www.nerdfitness.com/blog/brew-a-balanced-plate/

Halloween is just around the corner, and while I won’t be handing out any spell books, I will share a little witchcraft for building meals that actually work in real life. 🪄

One of my clients was struggling recently. Between long workdays and late nights caring for her sick pup, she didn’t have the time or brainpower to cook elaborate meals. She wanted something simple:

<img s…

A 5-minute daily mobility routine to keep your joints buttery

Source https://www.nerdfitness.com/blog/5-minute-mobility/

I got a great follow-up question to my recent newsletter about “​What does enough fitness look like?​” 🧐 And I thought it may help you, too.

“…in the email, you recommended a 5-minute daily flexibility check-in to check-in with how your body is feeling, and you mentioned a few exercises. Could you speak on tha…

Source https://www.nerdfitness.com/blog/5-minute-mobility/

I got a great follow-up question to my recent newsletter about “​What does enough fitness look like?​” 🧐 And I thought it may help you, too.

“…in the email, you recommended a 5-minute daily flexibility check-in to check-in with how your body is feeling, and you mentioned a few exercises. Could you speak on tha…

3 things we’ve learned in 8 years of coaching

Source https://www.nerdfitness.com/blog/3-pitfalls/

Note: Make sure to read to the end for an important update about Nerd Fitness Coaching!

Over the past 8 years, we’ve had thousands of conversations with clients, Rebels, and community members.

We’ve run polls, read replies, and listened closely to what people struggle with.

Again and again, variations of three statements kept coming up.

  • “Just tell me what to do.”

    • <li data-slate-node="elem…

Source https://www.nerdfitness.com/blog/3-pitfalls/

Note: Make sure to read to the end for an important update about Nerd Fitness Coaching!

Over the past 8 years, we’ve had thousands of conversations with clients, Rebels, and community members.

We’ve run polls, read replies, and listened closely to what people struggle with.

Again and again, variations of three statements kept coming up.

  • “Just tell me what to do.”

    • <li data-slate-node="elem…

From Pain to Peace: How to Grieve and Release Unmet Expectations

Source https://tinybuddha.com/blog/from-pain-to-peace-how-to-grieve-and-release-unmet-expectations/

“The wound is the place where the Light enters you.” ~Rumi

Before 2011, I had heard many spiritual teachers talk about “accepting what is.” It sounded nice in theory, like good mental information to chew on. But it didn’t feel embodied. I understood it intellectually, but I wasn’t living it.

Then I attended a weekend intensive with a teacher I deeply respected, and something in the way he explained it hit deeper. It wasn’t just talk. The essence of his words turned a spiritual idea into something I could start to live.

In that talk, he shared a story about a father whose son had become…

Source https://tinybuddha.com/blog/from-pain-to-peace-how-to-grieve-and-release-unmet-expectations/

“The wound is the place where the Light enters you.” ~Rumi

Before 2011, I had heard many spiritual teachers talk about “accepting what is.” It sounded nice in theory, like good mental information to chew on. But it didn’t feel embodied. I understood it intellectually, but I wasn’t living it.

Then I attended a weekend intensive with a teacher I deeply respected, and something in the way he explained it hit deeper. It wasn’t just talk. The essence of his words turned a spiritual idea into something I could start to live.

In that talk, he shared a story about a father whose son had become…

7 Things Pro Organizers Say You Should Declutter This Fall

Source https://www.theminimalists.com/autumn/

The Minimalists discuss seven items to consider decluttering this autumn—or any time of year.

What do you do to prepare for fall? Let us know in the YouTube comments.

The post 7 Things Pro Organizers Say You Should Declutter This Fall appeared first on The Minimalists.

…

Source https://www.theminimalists.com/autumn/

The Minimalists discuss seven items to consider decluttering this autumn—or any time of year.

What do you do to prepare for fall? Let us know in the YouTube comments.

The post 7 Things Pro Organizers Say You Should Declutter This Fall appeared first on The Minimalists.

…

Reviewing the Aging of the Liver

Source https://www.fightaging.org/archives/2025/10/reviewing-the-aging-of-the-liver/

The liver is perhaps the most regenerative organ in the body, but like all other organs it is negatively affected by the accumulation of cell and tissue damage characteristic of aging. Liver function is reduced, while prevalent liver diseases such as metabolic dysfunction-associated steatoheptatitis occur more readily in older people than in younger people. With this in mind, researchers here present a tour of vulnerabilities to disease and dysfunction that are induced by mechanisms of aging in the liver.

While the liver can maintain some of its homeostatic functions throughout aging, it becomes highly susceptible to liver injury and chronic liver disease. This s…

Source https://www.fightaging.org/archives/2025/10/reviewing-the-aging-of-the-liver/

The liver is perhaps the most regenerative organ in the body, but like all other organs it is negatively affected by the accumulation of cell and tissue damage characteristic of aging. Liver function is reduced, while prevalent liver diseases such as metabolic dysfunction-associated steatoheptatitis occur more readily in older people than in younger people. With this in mind, researchers here present a tour of vulnerabilities to disease and dysfunction that are induced by mechanisms of aging in the liver.

While the liver can maintain some of its homeostatic functions throughout aging, it becomes highly susceptible to liver injury and chronic liver disease. This s…

Are Socioeconomic Correlations with Disease Explained by Different Lifestyle Choices?

Source https://www.fightaging.org/archives/2025/10/are-socioeconomic-correlations-with-disease-explained-by-different-lifestyle-choices/

When examining human epidemiological data, a web of correlations link health, life span, education, wealth, intelligence, and socioeconomic status. One can hypothesize about why these correlations exist, and to what degree different mechanisms contribute to the overall effect, but it remains challenging to draw firm conclusions from the data. For example, reasonably compelling evidence suggests t…

Source https://www.fightaging.org/archives/2025/10/are-socioeconomic-correlations-with-disease-explained-by-different-lifestyle-choices/

When examining human epidemiological data, a web of correlations link health, life span, education, wealth, intelligence, and socioeconomic status. One can hypothesize about why these correlations exist, and to what degree different mechanisms contribute to the overall effect, but it remains challenging to draw firm conclusions from the data. For example, reasonably compelling evidence suggests t…

Towards an Induced Partial Reprogramming Approach to Alzheimer's Disease

Source https://www.fightaging.org/archives/2025/10/towards-an-induced-partial-reprogramming-approach-to-alzheimers-disease/

Gene therapies for neurodegenerative diseases that involve direct injection into portions of the brain have become acceptable enough to regulators that there is now progress towards the clinic on this front. This is despite the invasive nature of the delivery, and despite the high bar for safety that that tends to be applied to treatments that produce permanent changes in a patient. One might look at a recent trial for Huntington’s disease, for example. This willingness on the part of regulators to allow more adventurous approaches might reflect a growing frustration with the failure to generate curative (or even meaningfully preventative) therapies for prevalent neurodegenerative conditions, after decades of significant funding and effort.

Another example at an earlier stage of development is the repro…

Source https://www.fightaging.org/archives/2025/10/towards-an-induced-partial-reprogramming-approach-to-alzheimers-disease/

Gene therapies for neurodegenerative diseases that involve direct injection into portions of the brain have become acceptable enough to regulators that there is now progress towards the clinic on this front. This is despite the invasive nature of the delivery, and despite the high bar for safety that that tends to be applied to treatments that produce permanent changes in a patient. One might look at a recent trial for Huntington’s disease, for example. This willingness on the part of regulators to allow more adventurous approaches might reflect a growing frustration with the failure to generate curative (or even meaningfully preventative) therapies for prevalent neurodegenerative conditions, after decades of significant funding and effort.

Another example at an earlier stage of development is the repro…

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