Source https://www.fightaging.org/archives/2025/09/glp-1-receptor-agonist-use-reduces-heart-failure-mortality/
Losing weight improves health outcomes. To put it another way, carrying excess visceral fat tissue causes ongoing harm via a range of mechanisms connected to the disrupted, inflammatory metabolism it induces. Thus a growing number of studies demonstrate that weight loss achieved through GLP-1 receptor agonist use improves outcomes in the presently largely overweight populations of the wealthier regions of the world. It is always possible that GLP1-1 receptor agonist drugs have other effects that are meaningful along the way, but losing weight is so influential on health that very robust data would have to be presented to be convinci…
Source https://www.fightaging.org/archives/2025/09/glp-1-receptor-agonist-use-reduces-heart-failure-mortality/
Losing weight improves health outcomes. To put it another way, carrying excess visceral fat tissue causes ongoing harm via a range of mechanisms connected to the disrupted, inflammatory metabolism it induces. Thus a growing number of studies demonstrate that weight loss achieved through GLP-1 receptor agonist use improves outcomes in the presently largely overweight populations of the wealthier regions of the world. It is always possible that GLP1-1 receptor agonist drugs have other effects that are meaningful along the way, but losing weight is so influential on health that very robust data would have to be presented to be convinci…
Source https://www.fightaging.org/archives/2025/09/fight-aging-newsletter-september-15th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
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Source https://www.fightaging.org/archives/2025/09/fight-aging-newsletter-september-15th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
<a name="t…
Source https://seniorplanet.org/articles-meet-hotline-nita-flores/
Senior Planet Hotline rep Nita is a Brooklyn resident who hosts a sci-fi podcast and enjoys helping older adults embrace new technology.
The post Meet the Hotline Rep: Nita Flores appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-meet-hotline-nita-flores/
Senior Planet Hotline rep Nita is a Brooklyn resident who hosts a sci-fi podcast and enjoys helping older adults embrace new technology.
The post Meet the Hotline Rep: Nita Flores appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/play-september-ignite-your-exploration/
Test your skills with our monthly crossword puzzle. This month’s theme of Efficient Living will have you pulling from your smart-tech back pocket for answers!
The post Play September: Ignite Your Exploration appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/play-september-ignite-your-exploration/
Test your skills with our monthly crossword puzzle. This month’s theme of Efficient Living will have you pulling from your smart-tech back pocket for answers!
The post Play September: Ignite Your Exploration appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/09/the-goal-of-reversing-immune-aging/
It is difficult to overstate the importance of immune system dysfunction as a component of degenerative aging. All of the common fatal age-related diseases are strongly connected to immune dysfunctions, particularly the chronic inflammation that occurs with age. At the high level, researchers tend to divide immune aging into two components: immunosenescence is a loss of the ability of the immune system to defend against pathogens and destroy unwanted cells; inflammaging is a state of continual, unresolved inflammatory signaling, a maladaptive reaction to the altered environment and <a href="https://www.fightaging.org/faq/#causes-of-agin…
Source https://www.fightaging.org/archives/2025/09/the-goal-of-reversing-immune-aging/
It is difficult to overstate the importance of immune system dysfunction as a component of degenerative aging. All of the common fatal age-related diseases are strongly connected to immune dysfunctions, particularly the chronic inflammation that occurs with age. At the high level, researchers tend to divide immune aging into two components: immunosenescence is a loss of the ability of the immune system to defend against pathogens and destroy unwanted cells; inflammaging is a state of continual, unresolved inflammatory signaling, a maladaptive reaction to the altered environment and <a href="https://www.fightaging.org/faq/#causes-of-agin…
Source https://www.nerdfitness.com/blog/workouts-for-busy-parents/
I got this message the other week, and it felt so. Freaking. Relatable.
“…the biggest challenge right now is that I am a full-time working mother of two young boys and I’m just so freaking exhausted.
I’m on a hamster wheel of life right now, giving of myself to everyone and everything around me.
It’s not just that it’s hard to find the time to work out…it’s hard to find the energy.
<div class="blockquotes-line…
Source https://www.nerdfitness.com/blog/workouts-for-busy-parents/
I got this message the other week, and it felt so. Freaking. Relatable.
“…the biggest challenge right now is that I am a full-time working mother of two young boys and I’m just so freaking exhausted.
I’m on a hamster wheel of life right now, giving of myself to everyone and everything around me.
It’s not just that it’s hard to find the time to work out…it’s hard to find the energy.
<div class="blockquotes-line…
Source https://www.fightaging.org/archives/2025/09/yet-more-mouse-data-on-fisetin-as-a-senotherapeutic/
Mouse data has consistently shown fisetin to be senolytic, capable of selectively destroying the senescent cells that accumulate in tissues with age. Doses most often used are equivalent to around 20 mg/kg in humans, but dosing strategies range from a one-time course of treatment of a few days to intermittent doses provided over months. Unfortunately, despite planned and actually undertaken human trials of fisetin supplementation, there is still no published data of its senolytic capacity in humans. The dasatinib and quercertin combination and the locally delivered senolytic dev…
Source https://www.fightaging.org/archives/2025/09/yet-more-mouse-data-on-fisetin-as-a-senotherapeutic/
Mouse data has consistently shown fisetin to be senolytic, capable of selectively destroying the senescent cells that accumulate in tissues with age. Doses most often used are equivalent to around 20 mg/kg in humans, but dosing strategies range from a one-time course of treatment of a few days to intermittent doses provided over months. Unfortunately, despite planned and actually undertaken human trials of fisetin supplementation, there is still no published data of its senolytic capacity in humans. The dasatinib and quercertin combination and the locally delivered senolytic dev…
Source https://tinybuddha.com/blog/what-if-growth-is-about-removing-not-adding-more-to-your-life/
“Maybe the journey isn’t so much about becoming anything. Maybe it’s about un-becoming everything that isn’t really you, so you can be who you were meant to be in the first place.” ~Paulo Coelho
For years, any time I felt sadness, insecurity, loneliness, or any of those “unwelcome” feelings, I jumped into action.
I’d look for something new to take on: a class, a language, a project, a degree. Once, in the span of a single week, I signed up for language classes, researched getting certified in something I didn’t actually want to do, and convinced myself I needed to start training for a 10K.
Because if I was doing something productive, I wouldn’t have to sit with what I was feeling. Tha…
Source https://tinybuddha.com/blog/what-if-growth-is-about-removing-not-adding-more-to-your-life/
“Maybe the journey isn’t so much about becoming anything. Maybe it’s about un-becoming everything that isn’t really you, so you can be who you were meant to be in the first place.” ~Paulo Coelho
For years, any time I felt sadness, insecurity, loneliness, or any of those “unwelcome” feelings, I jumped into action.
I’d look for something new to take on: a class, a language, a project, a degree. Once, in the span of a single week, I signed up for language classes, researched getting certified in something I didn’t actually want to do, and convinced myself I needed to start training for a 10K.
Because if I was doing something productive, I wouldn’t have to sit with what I was feeling. Tha…
Source https://www.fightaging.org/archives/2025/09/reviewing-what-is-known-of-glial-cell-aging-in-the-cerebellum/
The category of glial cells covers all of the supporting cells of the brain, everything not a neuron, a big tent that includes immune cells such as microglia, the oligodendrocytes that manufacture myelin sheathing for axons, and the sizable astrocyte population, among others. These are very different cell populations with very different functions and behaviors, but all become dysfunctional with age. The present consensus is that glial cell dysfunction is important in aging and neurodegenerative conditions, each population contributing to loss of cognitive fun…
Source https://www.fightaging.org/archives/2025/09/reviewing-what-is-known-of-glial-cell-aging-in-the-cerebellum/
The category of glial cells covers all of the supporting cells of the brain, everything not a neuron, a big tent that includes immune cells such as microglia, the oligodendrocytes that manufacture myelin sheathing for axons, and the sizable astrocyte population, among others. These are very different cell populations with very different functions and behaviors, but all become dysfunctional with age. The present consensus is that glial cell dysfunction is important in aging and neurodegenerative conditions, each population contributing to loss of cognitive fun…
Source https://www.fightaging.org/archives/2025/09/the-ccnd1-cdk6-complex-as-a-target-for-senotherapeutics/
Senescent cells accumulate with age in tissues throughout the body, primarily when a cell reaches the Hayflick limit on replication, but also because of damage or stress. When a cell becomes senescent it ceases to replicate and undergoes profound metabolic changes that cause it to secrete a pro-inflammatory, pro-growth set of signals known as the senescence-associated secretory phenotype (SASP). This serves a useful purpose in the context of potentially cancerous cells, attracting the immune system to destroy them, and aids in regeneration from…
Source https://www.fightaging.org/archives/2025/09/the-ccnd1-cdk6-complex-as-a-target-for-senotherapeutics/
Senescent cells accumulate with age in tissues throughout the body, primarily when a cell reaches the Hayflick limit on replication, but also because of damage or stress. When a cell becomes senescent it ceases to replicate and undergoes profound metabolic changes that cause it to secrete a pro-inflammatory, pro-growth set of signals known as the senescence-associated secretory phenotype (SASP). This serves a useful purpose in the context of potentially cancerous cells, attracting the immune system to destroy them, and aids in regeneration from…
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