Source https://www.theminimalists.com/p504/
In this solo episode, Joshua talks about disagreeing about the little things at home, his new rule for online shopping, a few stupid things he’s purchased that he’ll never buy again, and much more.
Listen to the Episode
Discussed in This Episode
- Why do my minimalist spouse and I keep arguing about the little things?
- Talkaboutable: The Amazon Shopping Rule.
- <span style="font-weight…
Bienestar y Cambio con Lorena Jirón
Source https://seniorplanet.org/articles-es-bienestar-y-cambio-con-lorena-jiron/
¡Bienvenidos! Están invitados a unirse a esta serie de cuatro sesiones para explorar el autocuidado y el empoderamiento después de los 60.
The post Bienestar y Cambio con Lorena Jirón appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-es-bienestar-y-cambio-con-lorena-jiron/
¡Bienvenidos! Están invitados a unirse a esta serie de cuatro sesiones para explorar el autocuidado y el empoderamiento después de los 60.
The post Bienestar y Cambio con Lorena Jirón appeared first on Senior Planet from AARP.
…
Fight Aging! Newsletter, September 8th 2025
Source https://www.fightaging.org/archives/2025/09/fight-aging-newsletter-september-8th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
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Source https://www.fightaging.org/archives/2025/09/fight-aging-newsletter-september-8th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
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Open Thread: The End of a *Bop TWEE!* Era
Source https://seniorplanet.org/articles-open-thread-the-end-of-aol/
Share your first brush with AOL’s dial up service while those CD discs join VCR players, Blackberries and pagers on the ash heap of tech history – unless you still have them, of course!
The post Open Thread: The End of a <em>*Bop TWEE!*</em> Era appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-open-thread-the-end-of-aol/
Share your first brush with AOL’s dial up service while those CD discs join VCR players, Blackberries and pagers on the ash heap of tech history – unless you still have them, of course!
The post Open Thread: The End of a <em>*Bop TWEE!*</em> Era appeared first on Senior Planet from AARP.
…
Towards a Better Understanding of Lysosomal Stress
Source https://www.fightaging.org/archives/2025/09/towards-a-better-understanding-of-lysosomal-stress/
Lysosomes are recycling systems inside a cell, organelles that contain enzymes capable of breaking down proteins and cell structures into raw materials for reuse. The cell maintenance processes of autophagy are responsible for identifying proteins and structures that should be recycled and deliver them to a lysosome. Lysosomal dysfunction is a feature of aging in long-lived cells, as the lysosomes become filled with persistent metabolic waste that they struggle to break down. Enlargement of lysosomes is observed in this situation, and researchers here explore this phenomenon with an eye to find ways to manipulate lysosomal…
Source https://www.fightaging.org/archives/2025/09/towards-a-better-understanding-of-lysosomal-stress/
Lysosomes are recycling systems inside a cell, organelles that contain enzymes capable of breaking down proteins and cell structures into raw materials for reuse. The cell maintenance processes of autophagy are responsible for identifying proteins and structures that should be recycled and deliver them to a lysosome. Lysosomal dysfunction is a feature of aging in long-lived cells, as the lysosomes become filled with persistent metabolic waste that they struggle to break down. Enlargement of lysosomes is observed in this situation, and researchers here explore this phenomenon with an eye to find ways to manipulate lysosomal…
Old Age and Low Fitness Independently Correlate with Risk of Arrhythmia
Arrythmia can be a precursor of later, more severe heart issues, indicative of a level of dysfunction in heart tissue arising due to aging or other causes. It can also result from electrolyte imbalances that in turn arise from lifestyle choices. Arrythmia is generally taken as a point of concern by physicians where it occurs in older patients. Here, researchers show that a low level of fitness is independently a risk factor in the development of arrythmia, distinctly from old age. There are many other well-known reasons to maintain fitness into later life, but perhaps this finding will motivate an additional segment of the population.
New research has revealed that older age and low aerobic fitness levels are strong and independent risk factors for a high burde…
Arrythmia can be a precursor of later, more severe heart issues, indicative of a level of dysfunction in heart tissue arising due to aging or other causes. It can also result from electrolyte imbalances that in turn arise from lifestyle choices. Arrythmia is generally taken as a point of concern by physicians where it occurs in older patients. Here, researchers show that a low level of fitness is independently a risk factor in the development of arrythmia, distinctly from old age. There are many other well-known reasons to maintain fitness into later life, but perhaps this finding will motivate an additional segment of the population.
New research has revealed that older age and low aerobic fitness levels are strong and independent risk factors for a high burde…
Dysfunction in Cerebrovascular Blood Flow in Alzheimer's Disease
To what degree is the neurodegeneration of Alzheimer’s disease driven by reduced blood flow to brain tissue? This is as compared to the contributions of the well-studied aggregation of amyloid-β and tau proteins, or the neuroinflammation driven by senescent cells, persistent viral infection, and various forms of molecular damage in and around cells. One of the challenges inherent in investigations of aging and age-related disease is that it is very hard to determine the relativ…
To what degree is the neurodegeneration of Alzheimer’s disease driven by reduced blood flow to brain tissue? This is as compared to the contributions of the well-studied aggregation of amyloid-β and tau proteins, or the neuroinflammation driven by senescent cells, persistent viral infection, and various forms of molecular damage in and around cells. One of the challenges inherent in investigations of aging and age-related disease is that it is very hard to determine the relativ…
Interactions Between Oral and Gut Microbiomes in the Context of Age-Related Disease
The gut microbiome has received a great deal of attention in recent years, spurred by the ability to accurately and cheaply assess the composition of the gut microbiome, specific species and their proportions, via 16S rRNA sequencing. Researchers have demonstrated that the composition of the gut microbiome shifts with age to favor species that generate chronic inflammation at the expense of species producing beneficial metabolites needed for tissue function. Researchers are also turning th…
The gut microbiome has received a great deal of attention in recent years, spurred by the ability to accurately and cheaply assess the composition of the gut microbiome, specific species and their proportions, via 16S rRNA sequencing. Researchers have demonstrated that the composition of the gut microbiome shifts with age to favor species that generate chronic inflammation at the expense of species producing beneficial metabolites needed for tissue function. Researchers are also turning th…
Herpes Zoster Vaccination Correlates with Lower Risk of Stroke and Heart Attack
Vaccinations have been shown to produce a phenomenon called trained immunity. Effects include (a) increased responsiveness to pathogens other than the one vaccinated against, and (b) reduced chronic inflammation in later life. Trained immunity is well studied for the former phenomenon, but less well studied for the latter; questions remain as to whether different forms of vaccination for the same pathogen have different effects, for example. Correlations between later life vaccination and reduced risk of age-related disease and dysfunction have been observed, but it remains an open question as to whether this reflects trained immunity effects versus late life vaccination, a voluntary process, selecting for …
Vaccinations have been shown to produce a phenomenon called trained immunity. Effects include (a) increased responsiveness to pathogens other than the one vaccinated against, and (b) reduced chronic inflammation in later life. Trained immunity is well studied for the former phenomenon, but less well studied for the latter; questions remain as to whether different forms of vaccination for the same pathogen have different effects, for example. Correlations between later life vaccination and reduced risk of age-related disease and dysfunction have been observed, but it remains an open question as to whether this reflects trained immunity effects versus late life vaccination, a voluntary process, selecting for …
3 times motivation dips (and what to do about it)
Source https://www.nerdfitness.com/blog/3-times-motivation-dips/
I’m trying something a little different today.
Over the past 15 years of working with clients, I’ve learned that success in fitness isn’t just about knowing what to do… it’s about having strategies for when things inevitably get tough.
Where do habits usually break down? Why does motivation fizzle out? And what can we actually do about it?
…
Source https://www.nerdfitness.com/blog/3-times-motivation-dips/
I’m trying something a little different today.
Over the past 15 years of working with clients, I’ve learned that success in fitness isn’t just about knowing what to do… it’s about having strategies for when things inevitably get tough.
Where do habits usually break down? Why does motivation fizzle out? And what can we actually do about it?
…