Source https://www.fightaging.org/archives/2025/08/fight-aging-newsletter-august-4th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
Source https://www.fightaging.org/archives/2025/08/fight-aging-newsletter-august-4th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
Contents
Source https://www.americanspa.com/resource/lycon-pinkini-hard-wax-beads
LYCON PINKINI Hard Wax Beads
LYCON Pinkini Hot Wax Beads are designed for the most sensitive areas. Enriched with soothing Chamomile and calming Calendula, PINKINI delivers a virtually pain-free waxing experience. Perfect for Brazilians, it removes short hair with ease, leaving skin smooth, soft, and irritation-free.
swheeler
Tue, 06/03/2025 – 17:08
<div class="field field–name-field-introduction field–type-string-long field-…
Source https://www.americanspa.com/resource/lycon-pinkini-hard-wax-beads
LYCON PINKINI Hard Wax Beads
LYCON Pinkini Hot Wax Beads are designed for the most sensitive areas. Enriched with soothing Chamomile and calming Calendula, PINKINI delivers a virtually pain-free waxing experience. Perfect for Brazilians, it removes short hair with ease, leaving skin smooth, soft, and irritation-free.
swheeler
Tue, 06/03/2025 – 17:08
<div class="field field–name-field-introduction field–type-string-long field-…
Source https://seniorplanet.org/articles-annual-tech-review-sneak-preview/
Read an exclusive excerpt from 2025’s upcoming Technology Review and its collection of tech tips, hacks, and recommendations.
The post Annual Tech Review Sneak Preview appeared first on Senior Planet from AARP.
…
Source https://seniorplanet.org/articles-annual-tech-review-sneak-preview/
Read an exclusive excerpt from 2025’s upcoming Technology Review and its collection of tech tips, hacks, and recommendations.
The post Annual Tech Review Sneak Preview appeared first on Senior Planet from AARP.
…
Source https://www.fightaging.org/archives/2025/07/cellular-senescence-in-osteoblasts-as-a-contributing-cause-of-osteoporosis/
Cells that become senescent cease to replicate and secrete inflammatory signals that are disruptive to tissue structure and function. This happens constantly throughout life, largely as the result of cells reaching the Hayflick limit on replication, but also as a result of stress, damage, or a toxic local environment. In youth, newly created senescent cells are cleared rapidly by the immune system. With age, this clearance is impaired and the number of senescent cells in every cell population increases, contributing to age-related dysfunction and disease.
In today’s open access paper, researchers discuss the biochemistry and role of…
Source https://www.fightaging.org/archives/2025/07/cellular-senescence-in-osteoblasts-as-a-contributing-cause-of-osteoporosis/
Cells that become senescent cease to replicate and secrete inflammatory signals that are disruptive to tissue structure and function. This happens constantly throughout life, largely as the result of cells reaching the Hayflick limit on replication, but also as a result of stress, damage, or a toxic local environment. In youth, newly created senescent cells are cleared rapidly by the immune system. With age, this clearance is impaired and the number of senescent cells in every cell population increases, contributing to age-related dysfunction and disease.
In today’s open access paper, researchers discuss the biochemistry and role of…
Source https://www.fightaging.org/archives/2025/08/reviewing-the-aging-of-the-intestines/
Humans tend to die from cardiovascular aging, while flies tend to die from intestinal aging. The intestines of humans age and become dysfunctional, as they do in flies, of course. But intestinal aging usually isn’t a severe enough cause of issues in and of itself to win out over cardiovascular disease, pulmonary disease, and the other more common causes of death. It may well contribute meaningfully to all of those other causes of mortality! The converse can be said for the aging of the cardiovascular system in f…
Source https://www.fightaging.org/archives/2025/08/reviewing-the-aging-of-the-intestines/
Humans tend to die from cardiovascular aging, while flies tend to die from intestinal aging. The intestines of humans age and become dysfunctional, as they do in flies, of course. But intestinal aging usually isn’t a severe enough cause of issues in and of itself to win out over cardiovascular disease, pulmonary disease, and the other more common causes of death. It may well contribute meaningfully to all of those other causes of mortality! The converse can be said for the aging of the cardiovascular system in f…
Source https://www.fightaging.org/archives/2025/08/an-example-of-the-harms-done-by-too-little-circulating-klotho/
When people talk about klotho, they usually mean α-klotho, and specifically the soluble fragment of α-klotho that is secreted by cells to circulate in the body. Researchers have demonstrated in animal studies that high levels of α-klotho slow aging to extend life while low levels accelerate aging to shorten life. In humans, higher circulating levels of α-klotho correlate with a lower risk of age-related disease and longer life expectancy, and vice versa. Enumerating the mechanisms by which α-klotho affects the pace of aging, and determining which are more or less important than the others, remains a work in progress. The research noted here is an example of this ongoing work, and is focused on the effects that α-klotho ha…
Source https://www.fightaging.org/archives/2025/08/an-example-of-the-harms-done-by-too-little-circulating-klotho/
When people talk about klotho, they usually mean α-klotho, and specifically the soluble fragment of α-klotho that is secreted by cells to circulate in the body. Researchers have demonstrated in animal studies that high levels of α-klotho slow aging to extend life while low levels accelerate aging to shorten life. In humans, higher circulating levels of α-klotho correlate with a lower risk of age-related disease and longer life expectancy, and vice versa. Enumerating the mechanisms by which α-klotho affects the pace of aging, and determining which are more or less important than the others, remains a work in progress. The research noted here is an example of this ongoing work, and is focused on the effects that α-klotho ha…
Source https://www.fightaging.org/archives/2025/08/too-much-klotho-increases-cancer-risk-in-cancer-survivors/
An infrequently discussed topic in aging circles is the point that we should probably expect any therapy that improves tissue maintenance and regeneration in old people to also increase cancer risk. There isn’t much in the way of evidence to support that position, but it seems worthy of consideration. Cancer is a numbers game, and the greater the activity undertaken by stem cells and progenitor cells, the greater the likelihood of cancerous mutations. The only exceptions are interventions that act to improve the function of the immune system in addition to any other benefits that they produce; such treatments could lead to a net reduction in cancer risk, due to improved immunosurveillance of potent…
Source https://www.fightaging.org/archives/2025/08/too-much-klotho-increases-cancer-risk-in-cancer-survivors/
An infrequently discussed topic in aging circles is the point that we should probably expect any therapy that improves tissue maintenance and regeneration in old people to also increase cancer risk. There isn’t much in the way of evidence to support that position, but it seems worthy of consideration. Cancer is a numbers game, and the greater the activity undertaken by stem cells and progenitor cells, the greater the likelihood of cancerous mutations. The only exceptions are interventions that act to improve the function of the immune system in addition to any other benefits that they produce; such treatments could lead to a net reduction in cancer risk, due to improved immunosurveillance of potent…
Source https://www.fightaging.org/archives/2025/07/accelerated-biological-age-measures-correlate-with-a-higher-risk-of-disease-and-mortality/
Biological age acceleration is the name given to the state of exhibiting a predicted age from an aging clock that is higher than chronological age. Accelerated age via a clock measure is correlated with an increased risk of age-related disease and mortality. This has been demonstrated in a number of large epidemiological studies, and here researchers make use of the UK Biobank data to once again demonstrate that aging clocks do at least somewhat reflect the age-related risk of disease and mortality. Even so, it remains possible to argue over what exactly the clocks are measuring; calling it biological age is a lazy shortcut and possibly not the reality.
…
Source https://www.fightaging.org/archives/2025/07/accelerated-biological-age-measures-correlate-with-a-higher-risk-of-disease-and-mortality/
Biological age acceleration is the name given to the state of exhibiting a predicted age from an aging clock that is higher than chronological age. Accelerated age via a clock measure is correlated with an increased risk of age-related disease and mortality. This has been demonstrated in a number of large epidemiological studies, and here researchers make use of the UK Biobank data to once again demonstrate that aging clocks do at least somewhat reflect the age-related risk of disease and mortality. Even so, it remains possible to argue over what exactly the clocks are measuring; calling it biological age is a lazy shortcut and possibly not the reality.
…
Source https://tinybuddha.com/blog/left-side-pain-a-powerful-messenger-for-my-abandoned-parts/
“The body always leads us home… if we’re willing to listen.”
For over a decade, I lived in a body that tried to tell me something I wasn’t ready to hear. But eventually, it got louder—loud enough that I could no longer ignore the message.
It started with migraines—always on the left side.
Then came a string of sinus infections and dental issues—again, always on the left.
Lumps formed in my left breast. Then pain in my left ribs. Then a left-sided numbness that made doctors run MRIs for multiple sclerosis. Every test came back normal. And yet my body felt anything but.
At one point, I even developed pa…
Source https://tinybuddha.com/blog/left-side-pain-a-powerful-messenger-for-my-abandoned-parts/
“The body always leads us home… if we’re willing to listen.”
For over a decade, I lived in a body that tried to tell me something I wasn’t ready to hear. But eventually, it got louder—loud enough that I could no longer ignore the message.
It started with migraines—always on the left side.
Then came a string of sinus infections and dental issues—again, always on the left.
Lumps formed in my left breast. Then pain in my left ribs. Then a left-sided numbness that made doctors run MRIs for multiple sclerosis. Every test came back normal. And yet my body felt anything but.
At one point, I even developed pa…
Source https://www.fightaging.org/archives/2025/07/further-assessment-of-an-organ-specific-proteomic-aging-clock/
You might recall the development a few years ago of a proteomic aging clock that provided estimates of biological age for various organs in the body, rather than simply one overall measure. It was noted that individuals tended to have a distribution of biological ages across various organs, an individual’s organs age to different degrees. Here, researchers apply that clock to a subset of the UK Biobank population, and find that it produces the expected results. A higher predicted biological age for a given organ resulting from the clock algorithm correlates with a higher future risk of age-related disease in that organ, and the more organs exhibiting accelerated biological age, the greater the risk…
Source https://www.fightaging.org/archives/2025/07/further-assessment-of-an-organ-specific-proteomic-aging-clock/
You might recall the development a few years ago of a proteomic aging clock that provided estimates of biological age for various organs in the body, rather than simply one overall measure. It was noted that individuals tended to have a distribution of biological ages across various organs, an individual’s organs age to different degrees. Here, researchers apply that clock to a subset of the UK Biobank population, and find that it produces the expected results. A higher predicted biological age for a given organ resulting from the clock algorithm correlates with a higher future risk of age-related disease in that organ, and the more organs exhibiting accelerated biological age, the greater the risk…