It is never too late to start
Source https://seniorplanet.org/articles-get-social-and-mentor/
Is mentorship right for you – and are you right for it? Experts and mentors share stories, insights and practical tips on this fulfilling social activity.
The post Get Social – and Mentor! appeared first on Senior Planet from AARP.
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Source https://seniorplanet.org/articles-get-social-and-mentor/
Is mentorship right for you – and are you right for it? Experts and mentors share stories, insights and practical tips on this fulfilling social activity.
The post Get Social – and Mentor! appeared first on Senior Planet from AARP.
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The low (and still falling) cost of modern omics technologies ensure that databases of genetic information are expanding at a fast pace. Researchers who study aging have amassed a wealth of information on the biochemistry of people at various ages, but considerable focus has been placed on the genetics of extremely old individuals. The hope has always been to identify particular genes or protein interactions or other aspects of cellular biochemistry that are meaningfully protective, and thus could serve as a starting point for the development of therapies that will slow aging.
Unfortunately what has emerged from this research is (a) the likelihood that previous estimates of the contribution of genetic variants to life expectancy were too high, (b) that ve…
The low (and still falling) cost of modern omics technologies ensure that databases of genetic information are expanding at a fast pace. Researchers who study aging have amassed a wealth of information on the biochemistry of people at various ages, but considerable focus has been placed on the genetics of extremely old individuals. The hope has always been to identify particular genes or protein interactions or other aspects of cellular biochemistry that are meaningfully protective, and thus could serve as a starting point for the development of therapies that will slow aging.
Unfortunately what has emerged from this research is (a) the likelihood that previous estimates of the contribution of genetic variants to life expectancy were too high, (b) that ve…
Source https://www.theminimalists.com/p511/
The Minimalists speak with Ryan Holiday about how the stoics dealt with sentimental items, the potential virtue of holding on, stoical insights about values, regrets, mental clutter, seven things minimalists would never put in their living room, and much more.
Source https://www.theminimalists.com/p511/
The Minimalists speak with Ryan Holiday about how the stoics dealt with sentimental items, the potential virtue of holding on, stoical insights about values, regrets, mental clutter, seven things minimalists would never put in their living room, and much more.
Source https://www.fightaging.org/archives/2025/10/fight-aging-newsletter-october-27th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
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Source https://www.fightaging.org/archives/2025/10/fight-aging-newsletter-october-27th-2025/
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/
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Source https://www.theminimalists.com/shutup/
T.K. Coleman talks about how to get unstuck from conversations that make you feel trapped.
What was the last conversation you felt trapped in? Let us know in the YouTube comments.
The post How to Tell People to Shut Up appeared first on The Minimalists.
…
Source https://www.theminimalists.com/shutup/
T.K. Coleman talks about how to get unstuck from conversations that make you feel trapped.
What was the last conversation you felt trapped in? Let us know in the YouTube comments.
The post How to Tell People to Shut Up appeared first on The Minimalists.
…
Source https://www.fightaging.org/archives/2025/10/towards-engineered-mitochondria-for-therapy/
Cells can take up mitochondria from the surrounding environment, and researchers have demonstrated in mice that intravenous delivery of mitochondria allows some degree of replacement of the native populations in cells. This improves function when native mitochondria are dysfunctional, as occurs with age. At present, delivery of mitochondria as a therapy to restore mitochondrial function in older people is a work in progress. A few companies are working on the challenge, which largely involves developing the techniques needed to reliably manufacture mitochondria at scale. In this paper, researchers look beyond that effort to the next step in the road, which is to engineer the delivered mitochondria to be more efficient and more resilient, or to act as factories for therapeutic molecules, or to have some other desired capability.
Conventional mi…
Source https://www.fightaging.org/archives/2025/10/towards-engineered-mitochondria-for-therapy/
Cells can take up mitochondria from the surrounding environment, and researchers have demonstrated in mice that intravenous delivery of mitochondria allows some degree of replacement of the native populations in cells. This improves function when native mitochondria are dysfunctional, as occurs with age. At present, delivery of mitochondria as a therapy to restore mitochondrial function in older people is a work in progress. A few companies are working on the challenge, which largely involves developing the techniques needed to reliably manufacture mitochondria at scale. In this paper, researchers look beyond that effort to the next step in the road, which is to engineer the delivered mitochondria to be more efficient and more resilient, or to act as factories for therapeutic molecules, or to have some other desired capability.
Conventional mi…
The medical tourism industry has adopted the therapeutic use of exosomes derived from stem cells in much the same way as it adopted the use of stem cell therapies. Transplanted stem cells produce benefits via signaling, and most signaling is carried via extracellular vesicles such as exosomes. From a logistics point of view, exosomes are more easily stored, transported, and used, while all of the tools needed to harvest exosomes from stem cell cultures already existed. Meanwhile, the regulated medical industry lags years behind, given the large costs and lengthy development programs required to satisfy regulator…
The medical tourism industry has adopted the therapeutic use of exosomes derived from stem cells in much the same way as it adopted the use of stem cell therapies. Transplanted stem cells produce benefits via signaling, and most signaling is carried via extracellular vesicles such as exosomes. From a logistics point of view, exosomes are more easily stored, transported, and used, while all of the tools needed to harvest exosomes from stem cell cultures already existed. Meanwhile, the regulated medical industry lags years behind, given the large costs and lengthy development programs required to satisfy regulator…
Researchers here report on potential targets to enhance the regenerative capacity of alveolar type 2 cells, a population necessary for regeneration in lung tissue, but which falters in this duty in the context of progressive and age-related lung disease. Compensating for poorly understood mechanisms of damage and disease that direct alveolar type 2 cells away from regenerative activity can in principle be achieved by overriding the regulatory system that controls this aspect of cell behavior, provided enough is understood of how that regulatory system works. This approach to therapy doesn’t fix the underlying issues, but may well prove to be beneficial enough to pursue. There are numerous examples in the present practice of medicine of compensatory approaches that succeed in producing benefits for patients.
When a person’s lungs are damaged, that organ’s survival depends on a small but powerful set o…
Researchers here report on potential targets to enhance the regenerative capacity of alveolar type 2 cells, a population necessary for regeneration in lung tissue, but which falters in this duty in the context of progressive and age-related lung disease. Compensating for poorly understood mechanisms of damage and disease that direct alveolar type 2 cells away from regenerative activity can in principle be achieved by overriding the regulatory system that controls this aspect of cell behavior, provided enough is understood of how that regulatory system works. This approach to therapy doesn’t fix the underlying issues, but may well prove to be beneficial enough to pursue. There are numerous examples in the present practice of medicine of compensatory approaches that succeed in producing benefits for patients.
When a person’s lungs are damaged, that organ’s survival depends on a small but powerful set o…
Source https://tinybuddha.com/blog/a-quiet-but-powerful-shift-how-slowing-down-transformed-my-life/
“Slow down and enjoy life. It’s not only the scenery you miss by going too fast—you also miss the sense of where you are going and why.” ~Eddie Cantor
In today’s hyper-connected and fast-paced world, slowing down isn’t just rare—it feels almost countercultural.
For years, I tied my identity to productivity. My self-worth hinged on how much I could accomplish in a day, how many boxes I could check. The busier I was, the more valuable I believed myself to be. But that constant need to perform left me mentally and emotionally drained, disconnected not only from others but from myself.
The shift didn…
Source https://tinybuddha.com/blog/a-quiet-but-powerful-shift-how-slowing-down-transformed-my-life/
“Slow down and enjoy life. It’s not only the scenery you miss by going too fast—you also miss the sense of where you are going and why.” ~Eddie Cantor
In today’s hyper-connected and fast-paced world, slowing down isn’t just rare—it feels almost countercultural.
For years, I tied my identity to productivity. My self-worth hinged on how much I could accomplish in a day, how many boxes I could check. The busier I was, the more valuable I believed myself to be. But that constant need to perform left me mentally and emotionally drained, disconnected not only from others but from myself.
The shift didn…
A number of lines of research indicate that fat tissue becomes actively harmful to other tissues with advancing age via forms of signaling. Much of this work is focused on the role of excess visceral fat tissue in long-term health. Visceral fat acts to increase the burden of senescent cells, which then promote inflammation throughout the body via inflammatory signaling, but fat cells can also act to directly generate pro-inflammatory signaling in other ways, such as via mimicking the signaling generated by infected cells. These are not the …
A number of lines of research indicate that fat tissue becomes actively harmful to other tissues with advancing age via forms of signaling. Much of this work is focused on the role of excess visceral fat tissue in long-term health. Visceral fat acts to increase the burden of senescent cells, which then promote inflammation throughout the body via inflammatory signaling, but fat cells can also act to directly generate pro-inflammatory signaling in other ways, such as via mimicking the signaling generated by infected cells. These are not the …