Visceral Fat Correlates with Progression of Atherosclerosis

Source https://www.fightaging.org/archives/2025/10/visceral-fat-correlates-with-progression-of-atherosclerosis/

The more visceral fat that is present in the body, the greater the burden of atherosclerotic plaque narrowing and weakening major blood vessels. This isn’t just for those people who are very overweight, but the data shows that any degree of excess visceral fat correlates with a relative degree of acceleration of atherosclerosis: the more fat the worse the outcome. Visceral fat also contributes to other age-related conditions, with the most likely link being promotion of chronic inflammation via a number of different mechanisms. Visceral fat tissue promotes a greater burden of cellular senescence, fat ce…

Source https://www.fightaging.org/archives/2025/10/visceral-fat-correlates-with-progression-of-atherosclerosis/

The more visceral fat that is present in the body, the greater the burden of atherosclerotic plaque narrowing and weakening major blood vessels. This isn’t just for those people who are very overweight, but the data shows that any degree of excess visceral fat correlates with a relative degree of acceleration of atherosclerosis: the more fat the worse the outcome. Visceral fat also contributes to other age-related conditions, with the most likely link being promotion of chronic inflammation via a number of different mechanisms. Visceral fat tissue promotes a greater burden of cellular senescence, fat ce…

You Don’t Have to Be Strong All the Time

Source https://tinybuddha.com/blog/you-dont-have-to-be-strong-all-the-time/

“Sometimes the strongest thing you can do is to ask for help.” ~Unknown

We live in a world that praises strength—especially quiet strength. The kind that shows up, gets things done, and rarely complains. The kind that’s resilient, dependable, productive. But what happens when the strong one quietly breaks inside?

“You are a superwoman!”

“You’re so reliable!”

“You’re the glue that holds everyone together.”

I wore those compliments like badges of honor. For years, I believed them. Not just believed them—I built my ide…

Source https://tinybuddha.com/blog/you-dont-have-to-be-strong-all-the-time/

“Sometimes the strongest thing you can do is to ask for help.” ~Unknown

We live in a world that praises strength—especially quiet strength. The kind that shows up, gets things done, and rarely complains. The kind that’s resilient, dependable, productive. But what happens when the strong one quietly breaks inside?

“You are a superwoman!”

“You’re so reliable!”

“You’re the glue that holds everyone together.”

I wore those compliments like badges of honor. For years, I believed them. Not just believed them—I built my ide…

7 Things People Regret Tossing While Decluttering

Source https://www.theminimalists.com/regrets/

The Minimalists discuss common regrets people have after letting go.

What’s one item you regret decluttering? Let us know in the YouTube comments.

The post 7 Things People Regret Tossing While Decluttering appeared first on The Minimalists.

Source https://www.theminimalists.com/regrets/

The Minimalists discuss common regrets people have after letting go.

What’s one item you regret decluttering? Let us know in the YouTube comments.

The post 7 Things People Regret Tossing While Decluttering appeared first on The Minimalists.

Lower Circulating BDNF Level Correlates with Greater Cognitive Decline

Source https://www.fightaging.org/archives/2025/10/lower-circulating-bdnf-level-correlates-with-greater-cognitive-decline/

A range of research suggests that an increase in the circulating levels of BDNF is beneficial to the function of the brain (and likely muscle tissue as well). This is one of the ways in which alterations to the diet and gut microbiome composition can affect the brain, as microbial production of butyrate via fermentation of dietary fiber acts to increase BDNF expression. The research community has an interest in finding other ways to increase BDNF levels more directly, and that is a work in progress. Meanwhile, researchers continue to produce evidence t…

Source https://www.fightaging.org/archives/2025/10/lower-circulating-bdnf-level-correlates-with-greater-cognitive-decline/

A range of research suggests that an increase in the circulating levels of BDNF is beneficial to the function of the brain (and likely muscle tissue as well). This is one of the ways in which alterations to the diet and gut microbiome composition can affect the brain, as microbial production of butyrate via fermentation of dietary fiber acts to increase BDNF expression. The research community has an interest in finding other ways to increase BDNF levels more directly, and that is a work in progress. Meanwhile, researchers continue to produce evidence t…

Exploring Alternative Splicing as a Determinant of Species Life Span

Source https://www.fightaging.org/archives/2025/10/exploring-alternative-splicing-as-a-determinant-of-species-life-span/

A gene coding for a protein consists of multiple exon and intron sequences of DNA. During gene expression, the full DNA sequence of exons and introns is first transcribed into a RNA sequence, the primary transcript. That primary transcript undergoes a series of alterations that include RNA splicing. This splicing process removes the introns and stitches together the remaining exons to form a me…

Source https://www.fightaging.org/archives/2025/10/exploring-alternative-splicing-as-a-determinant-of-species-life-span/

A gene coding for a protein consists of multiple exon and intron sequences of DNA. During gene expression, the full DNA sequence of exons and introns is first transcribed into a RNA sequence, the primary transcript. That primary transcript undergoes a series of alterations that include RNA splicing. This splicing process removes the introns and stitches together the remaining exons to form a me…

Financial Planning for “Orphan Retirees”

Source https://seniorplanet.org/articles-financial-orphan-retirees/

More Americans are aging alone, without spouses or any close family members. These “orphan retirees” face special financial challenges.

The post Financial Planning for “Orphan Retirees” appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-financial-orphan-retirees/

More Americans are aging alone, without spouses or any close family members. These “orphan retirees” face special financial challenges.

The post Financial Planning for “Orphan Retirees” appeared first on Senior Planet from AARP.

Reviewing the Development of Senolytic Therapies for Neurodegenerative Conditions

Source https://www.fightaging.org/archives/2025/10/reviewing-the-development-of-senolytic-therapies-for-neurodegenerative-conditions/

Senescent cells accumulate with age in tissues throughout the body, generating sustained pro-inflammatory signaling that is increasingly disruptive to tissue structure and function. This is an important contribution to degenerative aging, as illustrated by the many animal studies in which senolytic therapies that selectively destroy senescent cells produce significant reversal of aspects of aging and age-related disease. Here, researchers review the evidence for senolytic therapies to effectively treat neurodegenerative conditions by removing the harms done by senescent cells in the brain.

<blockquo…

Source https://www.fightaging.org/archives/2025/10/reviewing-the-development-of-senolytic-therapies-for-neurodegenerative-conditions/

Senescent cells accumulate with age in tissues throughout the body, generating sustained pro-inflammatory signaling that is increasingly disruptive to tissue structure and function. This is an important contribution to degenerative aging, as illustrated by the many animal studies in which senolytic therapies that selectively destroy senescent cells produce significant reversal of aspects of aging and age-related disease. Here, researchers review the evidence for senolytic therapies to effectively treat neurodegenerative conditions by removing the harms done by senescent cells in the brain.

<blockquo…

Inspiring Story: Diane and Bari-Lynne Make a Horror Flick 

Source https://seniorplanet.org/articles-inspiring-story-horror-flick/

Diane Ament, 83, and Bari-Lynn, 79, were crew members for The Rug, a horror flick staffed completely by older adults, and which inspired the documentary Silver Screamers.

The post Inspiring Story: Diane and Bari-Lynne Make a Horror Flick  appeared first on Senior Planet from AARP.

Source https://seniorplanet.org/articles-inspiring-story-horror-flick/

Diane Ament, 83, and Bari-Lynn, 79, were crew members for The Rug, a horror flick staffed completely by older adults, and which inspired the documentary Silver Screamers.

The post Inspiring Story: Diane and Bari-Lynne Make a Horror Flick  appeared first on Senior Planet from AARP.

Feeling drained? Try this.

Source https://www.nerdfitness.com/blog/nourishment-menu/

There’s a cycle I see people get caught in all the time – and it makes staying on track with workouts and nutrition super difficult.

Here’s how one of my clients, Josh, put it:

“Things get super challenging (work/home/etc.) > less time > don’t get self care (time alone, workouts, etc.) > lower mood > makes things even more challenging > makes self care even less likely to happen > even lower mood > and so on.”

I know I can relate! 🙋‍♂️

Here’s the thing, often, people in these situations say: “I just need more motivation”, when what they need is more

Source https://www.nerdfitness.com/blog/nourishment-menu/

There’s a cycle I see people get caught in all the time – and it makes staying on track with workouts and nutrition super difficult.

Here’s how one of my clients, Josh, put it:

“Things get super challenging (work/home/etc.) > less time > don’t get self care (time alone, workouts, etc.) > lower mood > makes things even more challenging > makes self care even less likely to happen > even lower mood > and so on.”

I know I can relate! 🙋‍♂️

Here’s the thing, often, people in these situations say: “I just need more motivation”, when what they need is more

Exercise Can Partially Reverse the Age-Related Loss of Muscle Tissue Capillary Density

Source https://www.fightaging.org/archives/2025/10/exercise-can-partially-reverse-the-age-related-loss-of-muscle-tissue-capillary-density/

Every tissue is supported by countless capillaries, the smallest vessels in the branching vascular network. Take a square cross-section of tissue a millimeter in each dimension and one finds hundreds of capillaries passing through it. This intricate branching network of vessels must be constantly maintained, but unfortunately the processes of maintenance decline with age, as is the case for all complex systems in the body. The resulting progressive loss of capillary density reduces the supply of oxygen and nutrients, and this is thought to provide a meaningful contribution to loss of tissue function and the onset of age-related disease.

What can be done about this? Manipulating some of the regulators and participants at various stages of angiogenesis s…

Source https://www.fightaging.org/archives/2025/10/exercise-can-partially-reverse-the-age-related-loss-of-muscle-tissue-capillary-density/

Every tissue is supported by countless capillaries, the smallest vessels in the branching vascular network. Take a square cross-section of tissue a millimeter in each dimension and one finds hundreds of capillaries passing through it. This intricate branching network of vessels must be constantly maintained, but unfortunately the processes of maintenance decline with age, as is the case for all complex systems in the body. The resulting progressive loss of capillary density reduces the supply of oxygen and nutrients, and this is thought to provide a meaningful contribution to loss of tissue function and the onset of age-related disease.

What can be done about this? Manipulating some of the regulators and participants at various stages of angiogenesis s…

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