Category: Health and Fitness

Canagliflozin Reduces Pathology in the Aging Mouse Brain for Male Mice Only

Source https://www.fightaging.org/archives/2025/10/canagliflozin-reduces-pathology-in-the-aging-mouse-brain-for-male-mice-only/

Researchers have found that a number of antidiabetic drugs act to modestly slow aging in mice, albeit often differently by sex, while some effects are more reliable than others. Insulin metabolism was one of the first aspects of cell biochemistry to be well studied in the context of effects on aging, and drugs that affect insulin metabolism in the environment of the dysfunction of type 2 diabetes were thus thought likely to have at least some small effect on aging. The effect is indeed small and unreliable in some of the more studied drugs, such as metformin. Here, researchers assess the outcome of treatment with the antidiabetic drug <a href="https://en.wikipedia.org/wiki/C…

Source https://www.fightaging.org/archives/2025/10/canagliflozin-reduces-pathology-in-the-aging-mouse-brain-for-male-mice-only/

Researchers have found that a number of antidiabetic drugs act to modestly slow aging in mice, albeit often differently by sex, while some effects are more reliable than others. Insulin metabolism was one of the first aspects of cell biochemistry to be well studied in the context of effects on aging, and drugs that affect insulin metabolism in the environment of the dysfunction of type 2 diabetes were thus thought likely to have at least some small effect on aging. The effect is indeed small and unreliable in some of the more studied drugs, such as metformin. Here, researchers assess the outcome of treatment with the antidiabetic drug <a href="https://en.wikipedia.org/wiki/C…

Physical Fitness Correlates with a Slower Onset of Chronic Diseases of Aging

Source https://www.fightaging.org/archives/2025/10/physical-fitness-correlates-with-a-slower-onset-of-chronic-diseases-of-aging/

A sizable body of epidemiological evidence links physical fitness to improved health, greater longevity, and slowed aging in later life. Use it or lose it, as they say. Here researchers quantify the degree to which physical fitness can slow the onset of the chronic diseases of aging. Obviously one can’t escape degenerative aging via exercise, but given that maintaining fitness has one of the larger presently available effects on the long-term trajectory of health, why not make the effort?

Cardiorespiratory fitness (CRF) has been linked to lower risk of individual chronic diseases, but little is known about the CRF in relation to multimorbidity. Thus the authors here investigated the association between CRF and multimorbidity risk and explored differences in the trajector…

Source https://www.fightaging.org/archives/2025/10/physical-fitness-correlates-with-a-slower-onset-of-chronic-diseases-of-aging/

A sizable body of epidemiological evidence links physical fitness to improved health, greater longevity, and slowed aging in later life. Use it or lose it, as they say. Here researchers quantify the degree to which physical fitness can slow the onset of the chronic diseases of aging. Obviously one can’t escape degenerative aging via exercise, but given that maintaining fitness has one of the larger presently available effects on the long-term trajectory of health, why not make the effort?

Cardiorespiratory fitness (CRF) has been linked to lower risk of individual chronic diseases, but little is known about the CRF in relation to multimorbidity. Thus the authors here investigated the association between CRF and multimorbidity risk and explored differences in the trajector…

Chronic Inflammation and Differences in Frailty Between the Sexes

Source https://www.fightaging.org/archives/2025/10/chronic-inflammation-and-differences-in-frailty-between-the-sexes/

We are all well aware of the differences in life expectancy between women and men. The underlying reasons for the female advantage in longevity are much debated, but since similar sex differences exist across many species, it is likely to have deep roots in evolutionary biology and the complex interactions between reproductive fitness, mating strategies, and biochemistry. More prosaic explanations invoking the consequences of cultural and lifestyle choices that differ characteristically between sexes seem unlikely to be correct.

The situation is more complex than just a matter of life span, however. While living longer, women in late life exhibit a greater burden of disease and dysfunction than equivalently aged m…

Source https://www.fightaging.org/archives/2025/10/chronic-inflammation-and-differences-in-frailty-between-the-sexes/

We are all well aware of the differences in life expectancy between women and men. The underlying reasons for the female advantage in longevity are much debated, but since similar sex differences exist across many species, it is likely to have deep roots in evolutionary biology and the complex interactions between reproductive fitness, mating strategies, and biochemistry. More prosaic explanations invoking the consequences of cultural and lifestyle choices that differ characteristically between sexes seem unlikely to be correct.

The situation is more complex than just a matter of life span, however. While living longer, women in late life exhibit a greater burden of disease and dysfunction than equivalently aged m…

Podcast Ep. 510 | Say Less

Source https://www.theminimalists.com/p510/

The Minimalists talk about verbal minimalism, the things we regret saying, the best ways to let other people down, seven things people regret tossing while decluttering, and much more.

Listen to the Episode

Apple · Spotify · Patreon

Discussed in This Episode

  • How do you practice verbal minimalism?
  • What’s the last thing you regretted saying?
  • Right Here, Right Now: Joshua’s new…

Source https://www.theminimalists.com/p510/

The Minimalists talk about verbal minimalism, the things we regret saying, the best ways to let other people down, seven things people regret tossing while decluttering, and much more.

Listen to the Episode

Apple · Spotify · Patreon

Discussed in This Episode

  • How do you practice verbal minimalism?
  • What’s the last thing you regretted saying?
  • Right Here, Right Now: Joshua’s new…

Ask Joan: I Can’t Sleep with My Partner!

Source https://seniorplanet.org/articles-ask-joan-cant-sleep/

Joan counsels a woman who loves sex but not sleeping with her husband. Is it time for a “sleep divorce?” 

The post Ask Joan: I Can’t Sleep with My Partner! appeared first on Senior Planet from AARP.

…

Source https://seniorplanet.org/articles-ask-joan-cant-sleep/

Joan counsels a woman who loves sex but not sleeping with her husband. Is it time for a “sleep divorce?” 

The post Ask Joan: I Can’t Sleep with My Partner! appeared first on Senior Planet from AARP.

…

When Friendship Is One-Sided: Letting Go of Someone Who Was Never Really There

Source https://tinybuddha.com/blog/when-friendship-is-one-sided-letting-go-of-someone-who-was-never-really-there/

“Finally, I realized that I was never asking too much. I was just asking the wrong person.” ~Unknown

Friendship should nourish the soul. And in my life, for the most part, it has. I have a small, longstanding circle of friends steeped in a long-shared history. We’re basically a real-life, thirty-five-year-long John Hughes film.

However, every now and then, a hornet in disguise has buzzed into my life and stung.

He was one of them. A bad sting.

Love Bombing

Right off the bat, knowing him felt amazing.

I was still reeling from the aftereffects of living with…

Source https://tinybuddha.com/blog/when-friendship-is-one-sided-letting-go-of-someone-who-was-never-really-there/

“Finally, I realized that I was never asking too much. I was just asking the wrong person.” ~Unknown

Friendship should nourish the soul. And in my life, for the most part, it has. I have a small, longstanding circle of friends steeped in a long-shared history. We’re basically a real-life, thirty-five-year-long John Hughes film.

However, every now and then, a hornet in disguise has buzzed into my life and stung.

He was one of them. A bad sting.

Love Bombing

Right off the bat, knowing him felt amazing.

I was still reeling from the aftereffects of living with…

Fight Aging! Newsletter, October 20th 2025

Source https://www.fightaging.org/archives/2025/10/fight-aging-newsletter-october-20th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

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Source https://www.fightaging.org/archives/2025/10/fight-aging-newsletter-october-20th-2025/

Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe to the newsletter,
please visit:
https://www.fightaging.org/newsletter/.
To unsubscribe, send email or reply to this email at newsletter@fightaging.org with “unsubscribe” in the subject or body.

Longevity Industry Consulting Services

Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/

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Open Thread: Biggest Scares in Cinema

Source https://seniorplanet.org/articles-open-thread-movie-scare/

What movies were so scary that one viewing was enough for you?

The post Open Thread: Biggest Scares in Cinema appeared first on Senior Planet from AARP.

…

Source https://seniorplanet.org/articles-open-thread-movie-scare/

What movies were so scary that one viewing was enough for you?

The post Open Thread: Biggest Scares in Cinema appeared first on Senior Planet from AARP.

…

Ask The Techspert: What’s New in Accessibility on iOS 26

Source https://seniorplanet.org/articles-techspert-ios-26/

Learn more about iOS 26’s powerful new accessibility features that make the iPhone easier to see, hear, and control – for everyone.

The post Ask The Techspert: What’s New in Accessibility on iOS 26 appeared first on Senior Planet from AARP.

…

Source https://seniorplanet.org/articles-techspert-ios-26/

Learn more about iOS 26’s powerful new accessibility features that make the iPhone easier to see, hear, and control – for everyone.

The post Ask The Techspert: What’s New in Accessibility on iOS 26 appeared first on Senior Planet from AARP.

…

Physically Fitter Older Adults Exhibit Better Natural Killer Cell Function

Source https://www.fightaging.org/archives/2025/10/physically-fitter-older-adults-exhibit-better-natural-killer-cell-function/

Physical fitness confers a great many benefits. Based on the broad evidence for reduced mortality and improved health, it is worth the effort required to maintain an above average level of fitness into later life. The research noted here is one of many studies to look at specific immunological differences between relatively fit and relatively unfit older individuals. It is well understood that greater fitness produces improved immune function, but the immune system is very complex and there is a great deal of room for further exploration of the fine details.

Aging is asso…

Source https://www.fightaging.org/archives/2025/10/physically-fitter-older-adults-exhibit-better-natural-killer-cell-function/

Physical fitness confers a great many benefits. Based on the broad evidence for reduced mortality and improved health, it is worth the effort required to maintain an above average level of fitness into later life. The research noted here is one of many studies to look at specific immunological differences between relatively fit and relatively unfit older individuals. It is well understood that greater fitness produces improved immune function, but the immune system is very complex and there is a great deal of room for further exploration of the fine details.

Aging is asso…

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