Source https://www.fightaging.org/archives/2025/11/a-profile-of-sirtuins-1-3-and-6-in-aging-humans/
Sirtuins are involved in the regulation of metabolism in various ways, and are clearly quite important to cell function as their structure is very similar in species as divergent as yeast, flies, and humans. Sirtuin 1 as a target for interventions in aging was intensely overhyped and likely not actually very useful in a practical sense. Sirtuin 3 is more interesting, based on research suggesting that it could have calorie restriction mimetic effects, and is <a href="https://www.fightaging.org/archives/2025/08/reviewing-what…
Source https://www.fightaging.org/archives/2025/11/a-profile-of-sirtuins-1-3-and-6-in-aging-humans/
Sirtuins are involved in the regulation of metabolism in various ways, and are clearly quite important to cell function as their structure is very similar in species as divergent as yeast, flies, and humans. Sirtuin 1 as a target for interventions in aging was intensely overhyped and likely not actually very useful in a practical sense. Sirtuin 3 is more interesting, based on research suggesting that it could have calorie restriction mimetic effects, and is <a href="https://www.fightaging.org/archives/2025/08/reviewing-what…
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