Adenosine Signaling via the A1 Receptor Reverses Age-Related Decline in Neutrophil Function

Source https://www.fightaging.org/archives/2020/08/adenosine-signaling-via-the-a1-receptor-reverses-age-related-decline-in-neutrophil-function/

Neutrophils are an important component of the innate immune system, mounting a first response to infectious pathogens. An insufficient neutrophil response leads to a far more serious infection. Researchers here report on an exploration of mechanisms responsible for rousing neutrophils to action, and how they change with age. They find that stimulation of a specific cell surface receptor can reverse the age-related decline in efficiency of the neutrophil response to at least one specific infectious pathogen. Thus this might prove to be the basis for therapies capable of improving the capacity of the aged immune system to protect against infectious disease.

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