Alzheimer's as an Axonal Damage Condition

Source https://www.fightaging.org/archives/2023/11/alzheimers-as-an-axonal-damage-condition/

Axons are lengthy projections of the cell body that connect neurons, essential to the function of the brain. Researchers here view what is known of the biochemistry of Alzheimer’s disease through the lens of damage to axons. As they point out, the relentless focus on protein aggregation, particularly amyloid-β aggregation, in Alzheimer’s disease does tend to crowd out more in-depth discussions of what it is that this protein aggregation actually does to cells.

Alzheimer’s disease (AD) is the primary cause of dementia and is anticipated to impose a substantial economic burden in the future. Over a significant period, the wid…

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